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TCP10L negatively regulates alpha-fetoprotein expression in hepatocellular carcinoma
Suqin Shen,Huan Feng,Longjiang Liu,Wei Su,Jiaxue Wu,Long Yu 생화학분자생물학회 2020 BMB Reports Vol.53 No.8
Alpha-fetoprotein (AFP) is one of the most commonly used and reliable biomarkers for Hepatocellular carcinoma (HCC). However, the underlying mechanism of AFP expression in HCC is poorly understood. In this study, we found that TCP10L, a gene specifically expressed in the liver, is down-regulated in HCC and that its expression inversely correlates with AFP expression. Moreover, overexpression of TCP10L suppresses AFP expression whereas knockdown of TCP10L increases AFP expression, suggesting that TCP10L might be a negative regulator of AFP. We found that TCP10L is associated with the AFP promoter and inhibits AFP promoter-driven transcriptional activity. Taken together, these results indicate that TCP10L negatively regulates AFP expression in HCC and that it could be a potential prognostic marker and therapeutic target for HCC.
Weiyan Liu,Huiming Ji,Jian Wang,Xuerong Zheng,Junyun Lai,Junna Ji,Tongfei Li,Yuanliang Ma,Haiqin Li,Suqin Zhao,Zhengguo Jin 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.3
"Uniform hexagonal covellite CuS thin films were deposited at room temperature by an in situ solution chemical reaction using copper precursor solid films as cationic source and ammonium sulfide ethanol solution as anionic reaction medium. We investigated the influence of both ethanolamine and butanol contents used in copper nitrate/ethylene glycol monomethylether (EGME) cationic solution for the preparation of copper precursor solid films, deposition cycle numbers and annealing treatment of the as-grown thin films by X-ray diffraction (XRD), FESEM, energy dispersive X-ray fluorescence EDX, transmission electron microscopy–Selected area electronic diffraction (TEM–SAED), atomic force microscopy (AFM) and ultraviolet-visible-near-infrared (UV-Vis–NIR) measurements. Photo-response of the CuS thin films was characterized by linear sweep voltammetry. The deposited CuS thin films were used to sensitize TiO2 anodes for solar cell application. The results showed that the CuS films had two-dimension oriented, half-sheet shaped growing morphology standing disorderly but vertically to substrates, and the calculated texture coefficient TC(102) verified that the half-sheet shaped crystallites had (102) plane orientation. This in situ multi-deposition process had an average deposited rate of 9 nm per cycle, and a selfperfect function to grow smooth, uniform and 2D oriented morphology with increase in the dip-cycle numbers. The photocurrent density was 14.5 Ma/cm2 at 1 V versus Ag/AgCl electrode for the annealed CuS thin films. CuS-sensitized TiO2 solar cells had a maximum conversion efficiency of 0.224%."
GuanHua Jin,Suqin Liu,Yaomin Li,Yang Guo,Zhiying Ding 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.11
Development of efficient electrocatalysts for the oxygen reduction reaction (ORR) remains a key issue for the commercialization of metal-air batteries. In this study, the novel structured Co3O4 nanoparticles-modified α-MnO2 nanorods supported on reduced graphene oxide (Co3O4-MnO2/ rGO) were synthesized with varying amounts of α-MnO2 via a facile two-step hydrothermal method. The relationship between the physical properties and the electrochemical results was investigated using X-ray diffraction spectrum, scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, X-ray photoelectron spectroscopy, cyclic voltammograms, electrochemical impedance spectroscopy and rotating disk electrode. The as-prepared Co3O4– MnO2 nanohybrid exhibits enhanced catalytic activity for ORR under alkaline condition compared with MnO2/rGO and Co3O4/rGO. Furthermore, it mainly favors a direct 4e-reaction pathway for ORR, which is attributed to the well-designed structure, the synergistic effect between Co3O4 and α-MnO2, and the covalent coupling between the Co3O4-MnO2 and reduced graphene oxide. The role of Co3O4 in Co3O4–MnO2 hybrid for catalyzing ORR also has been illustrated by varying the mass ratio of Co3O4 and MnO2, which reveals that the Co3O4–MnO2 with the ratio of 1:1 has better catalytic activity.
Comparative Study and Electrochemical Properties of LiFePO4F Synthesized by Different Routes
Bin Huang,Suqin Liu,Hongliang Li,Shuxin Zhuang,Dong Fang 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.7
To improve the performance of LiFePO4F, a novel sol-gel process is developed. For comparison, ceramic process is also implemented. From X-ray diffraction results we know that each sample adopts a triclinic P1 space group, and they are isostructural with amblygonite and tavorite. The scanning electron microscope images show that the homogeneous grains with the dimension of 300-500 nm is obtained by the sol-gel process; meanwhile the sample particles obtained by ceramic process are as big as 1000-3000 nm. By galvanostatic tests and at electrochemical impedance spectroscopy method, the sample obtained by sol-gel process presents better electrochemical properties than the one obtained by ceramic process.
Huang, Bin,Liu, Suqin,Li, Hongliang,Zhuang, Shuxin,Fang, Dong Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.7
To improve the performance of $LiFePO_4F$, a novel sol-gel process is developed. For comparison, ceramic process is also implemented. From X-ray diffraction results we know that each sample adopts a triclinic $P{\bar{1}}$ space group, and they are isostructural with amblygonite and tavorite. The scanning electron microscope images show that the homogeneous grains with the dimension of 300-500 nm is obtained by the sol-gel process; meanwhile the sample particles obtained by ceramic process are as big as 1000-3000 nm. By galvanostatic tests and at electrochemical impedance spectroscopy method, the sample obtained by sol-gel process presents better electrochemical properties than the one obtained by ceramic process.
Ding, Xiangming,Yu, Wenbo,Liu, Ming,Shen, Suqin,Chen, Fang,Wan, Bo,Yu, Long Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.6
Septins are a family of conserved cytoskeletal GTPase forming heteropolymeric filamentous structure in interphase cells, however, the mechanism of assembly are largely unknown. Here we described the characterization of SEPT12, sharing closest homology to SEPT3 and SEPT9. It was revealed that subcelluar localization of SEPT12 varied at interphase and mitotic phase. While SEPT12 formed filamentous structures at interphase, it was localized to the central spindle and to midbody during anaphase and cytokinesis, respectively. In addition, we found that SEPT12 can interact with SEPT6 in vitro and in vivo, and this interaction was independent of the coiled coil domain of SEPT6. Further, co-expression of SEPT12 altered the filamentous structure of SEPT6 in Hela cells. Therefore, our result showed that the interaction between different septins may affect the septin filament structure.