http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Sungweon Kang (검색결과 11 건)
- 무료
- 기관 내 무료
- 유료
-
An Energy Combiner for a Multi-Input Energy-Harvesting System
Taewook Kang,Sungeun Kim,Changhee Hyoung,Sungweon Kang,Kyunghwan Park IEEE 2015 IEEE Transactions on Circuits and Systems II: Expr Vol. No.
<P>An energy combiner for delivering electrical energy harvested simultaneously from individual energy harvesters (EHs) to a single energy storage device such as a battery is presented. It is designed as a modular architecture to be handled as a subsystem and supports an arbitrary number of EHs, which can be connected to the energy combiner in a hot-pluggable form. With the adaptive connection flows of a novel control algorithm, the energy harvested from each EH can be transmitted to an energy storage device without interfering with each other. An evaluation system is implemented, including the energy combiner circuit fabricated in a 0.13-μm CMOS process. The experimental results show that the energy combiner, with a low power consumption of 1.55 μW, achieves a maximum energy-combining efficiency of up to 95% for three input sources.</P>
-
-
Kang, Heeyoon,Ryoo, Sungweon,Park, Youngkil,Lew, Woojin The Korean Academy of Tuberculosis and Respiratory 2009 Tuberculosis and Respiratory Diseases Vol.67 No.6
Background: Mycobacterial Interspersed Repetitive Units (MIRUs) that are located mainly in intergenic regions dispersed throughout the Mycobacterium tuberculosis genome. The selected MIRU loci, which were composed of a 12-locus set, demonstrated a high power for discrimination of Mycobacterium tuberculosis isolates collected from Kangwon province of Korea. To evaluate its ability to discriminate the M. tuberculosis strains, 45 clinical isolates were genotyped using the methods IS6110 RFLP and MIRU. Methods: All the samples were collected during the period from January 2007 to December 2007 from TB patients, who were residents and registered to a public health center of Kangwon Province in Korea. A total of 45 DNAs were extracted from clinical isolated mycobacterial strains and genotyped using IS6110 RFLP, the MIRU method. Results: We compared the 12-MIRU with IS6110 RFLP in the 45 samples, the 12-locus version offered less discriminatory power (Hunter-Gaston discriminatory index [HGDI]: 0.959 vs 0.998; 57.78% of clustered cases vs 8.89%). Conclusion: This 12-locus MIRU can be useful when additional combinations of other loci for genotyping M. tuberculosis in Korea where the Beijing family strains are dominant.
-
( Taeuk Kang ),( Yoohyun Hwang ),( Jiyeon Kim ),( Jihee Jung ),( Dagyum Lee ),( Sungweon Ryoo ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Purpose Tuberculosis (TB) remains as a serious public health burden in Korea due to ease transmission. Mycobacterial Interspersed Repetitive Unit-Variable Number Tandem Repeat (MIRU-VNTR) is preferred for epidemiological TB investigation. However, the MIRU-VNTR has issues that MIRU-VNTR kit by GenoScreen (GeMIRU) is hard to be procured in Korea hence the difficulty lies epidemiological TB investigation/research. Here, we have comparatively analyzed the MIRU-VNTR kit by Kogene (KoMIRU). Method The 200 DNA samples, where 100 samples were clinical M. tuberculosis DNA samples from Masan National Tuberculosis Hospital and other 100 samples were non-M. tuberculosis, were used. Then, 200 samples were typed using KoMIRU and GeMIRU and compared for comparative analysis. KoMIRU and GeMIRU were done using the protocols provided by each manufacturer’s manual. Lineage strains were identified using MIRU-VNTRplus database (https://www.miru-vntrplus.org/MIRU/ index.faces) Result Of 200 samples, all clinical M. tuberculosis samples were amplified while non-M. tuberculosis samples were not, showing 100% for both sensitivity and specificity with 95% Confidence of Interval value of 96.38 - 100.00% (Table 1). KoMIRU typing kit has shown successful differentiation of M. tuberculosis from non-M. tuberculosis species. Also, no discrepancies observed on determined lineage strains between KoMIRU and GeMIRU. Out of 100, 84 were identified as Beijing strains and remainings were identified as NEW-1 (n=8), Uganda (n=6), EAI (n=6), Turkey (n=2), and Harleem (n=1) (Figure 1). Interestingly, among those non-Beijing strains except EAI, they are geographically distant lineage strains, Uganda, Turkey, and Harleem, and relatively unique strain, NEW-1. Conclusion The effectiveness of preventive TB intervention using GeMIRU has been globally proved. In this study, KoMIRU has shown comparable capability as GeMIRU and localization of MIRU-VNTR by Kogene is expected to allow efficient TB investigation in Korea. Also, previous researches had suggested association between lineage strains and drug resistance hence, this can be applied to initial TB treatment.
-
( Jihye Kang ),( Da-gyum Lee ),( Yoohyun Hwang ),( Jiyeon Kim ),( Jihee Jung ),( Donghwan Jang ),( Sungweon Ryoo ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Purpose Anti-tuberculosis drug susceptibility testing (DST) is increasing in importance and demand for treatment. Supply of standardized high-quality DST medium and tuberculosis (TB) specimen titration are key technologies in the DST process. The purpose of this study was to evaluate test method that secures accuracy by taking advantage of the proportion tests. Methods To perform the anti-TB DST, an improved 6-well medium (Middlebrook 7H10 medium) produced in a GMP-qualified place was used. After inoculation in 6-well medium, it was compared with the result of REMA. The concentration of the drug added for the drug susceptibility test was based on the value recommended by WHO. Results The improved 6-well anti-TB DST medium produced in a GMP certified facility is expected to be able to replace the in-house medium used for phenotypic DST. Conclusions It is thought that the medium used for phenotype DST should be produced in a GMP certified facility in order to standardize and high quality. The improved 6-well medium is a meaningful attempt to improve the quality of DST. For the clinical introduction of an improved medium, additional experiments and verification work are required for TB strains with various drug resistance patterns.
-
( Taeuk Kang ),( Seungkyu Park ),( Sungweon Ryoo ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Background Tuberculosis still remains as intermediate-burden in Korea (Figure 1). For tuberculosis elimination, tuberculosis training/ education play pivotal role. Researches have suggested that provision of appropriate training/education could improve clinical outcome and prevent TB transmission. Despite significant role of TB training/education, TB training/education were poorly investigated. To assess current TB training/education program, identifying current status of TB training/education is inevitable. Hence, in this study, we reviewed articles and programs related to TB training/education in Korea and analyzed. Method A comprehensive review of literature on electronic databases and websites of TB-training providing organizations from year of 1995 to 2021 were undertaken. Result Several organizations from governmental/public sectors such as Korea Disease Control and Prevention Agency (KDCA), Korea National Tuberculosis Association (KNTA), Masan National Tuberculosis Hospital (MNTH), Korea Human Resource Development Institute for Health and Welfare (KOHI), Korea Nurses Association (KNA) were involved in provision of TB training/education. The KDCA conducts activities related to TB control and prevention at national, provincial, and local levels while KNTA, as commissioned by KDCA, provides TB trainings for healthcare workers with collaboration with KNA. In case of MNTH, this medical institute produced 14 TB medical specialists since 1993 and actively engaged in TB education at community level that 67,426 people were educated for TB prevention. Lastly, KOHI institutes provides several TB training/education programs for healthcare workers, medical technologists, and public (Table 1). Conclusion Although sufficient number of TB training/education are being provided. Its quality has never been assessed hence, there is difficulty lies in improvement of TB training/education due to lacking evaluation. Also, due to changing landscape of TB, training/education topics should reflect upcoming demands and be diversified such as inclusion of latent TB, drug-resistant TB and/or HIV/TB. The MNTH, with demonstrated history, is able to meet current demands from TB training/education.
-
( Taeuk Kang ),( Yoohyun Hwang ),( Jiyeon Kim ),( Jihee Jung ),( Dagyum Lee ),( Sungweon Ryoo ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Purpose Tuberculosis (TB) remains as public health burden in Korea. Beijing strain of Mycobacterium tuberculosis (M. tuberculosis) is assumed to be associated with hypervirulence and multi-drug resistance hence detection of such strain helps rapid detection of drug resistance. Thus, identification of Beijing strain is highly significant, in epidemiological and clinical aspects. Here, we present evaluation of the Real-time PCR kit for Beijing strain of Mycobacterium tuberculosis diagnostic® (KOGENE, Korea) (KOGENE RT-PCR) Method The 200 DNA samples, where 100 were clinical M. tuberculosis from Masan National Tuberculosis Hospital and other 100 were non-M. tuberculosis, were used. Strains of 100 M. tuberculosis were identified using MIRU-VNTR typing kit® (GenoScreen, France) and MIRU-VNTRplus database (URL: https://www.miru-vntrplus.org/MIRU/index.faces). Based on MIRU-VNTR result, the 84 out of 100 samples are identified as Beijing strain and remaining 16 samples are identified as non-Beijing strains. The KOGENE RT-PCR was conducted according to the manufacturer’s manual. Amplification of VIC fluorescence indicates M. tuberculosis-positive and amplification of both VIC and FAM fluorescences indicates Beijing strain of M. tuberculosis-positive. Result Of 200 samples, only 100 M. tuberculosis samples were amplified for VIC, showing 100% for both sensitivity and specificity with 95% Confidence of Interval (CI) value of 96.38-100%. Out of 100 M. tuberculosis, 84 Beijing strain of M. tuberculosis were positive for FAM, indicating 100% for both sensitivity and specificity with 95% CI values of 95.70-100% and 96.87-100% respectively (Table 1). Conclusion The clinical implication of Beijing strain is widely known. Here, investigated RT-PCR has shown capability in Beijing strain identification. Application of this tool could contribute in M. tuberculosis identification and prediction of possible drug resistance during pre- and initial treatment. Also, several outbreaks have been occurred by M. tuberculosis with Beijing strain. Hence, early identification of such strain is considered as highly useful in epidemiological TB investigation.
-
( Dagyum Lee ),( Jihye Kang ),( Yoohyun Hwang ),( Sungweon Ryoo ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Purpose The laboratory diagnosis of latent tuberculosis (LTB) is often performed using interferon-gamma(γ) release assays (IGRA). We compared two enzyme-linked immunosorbent assay (ELISA)-based IGRA, the Standard E TB-Feron ELISA (STFE; SD Biosensor, Gyeonggi-do, Republic of Korea) and the QuantiFERON-TB Gold PLUS assay (QFT-GP; Qiagen, Hilden, Germany), in 155 participants. Method All participants were classified into four groups and screened by both assays per the manufacturer’s protocols: group A who were not infected nor were in contact with TB patients, group B who were at an intermediate risk of TB infection, group C who were at a high risk of TB infection, and group D who were confirmed and completing TB treatment. Result The study conducted two statistical analysis. First, the Results of STFE were compared to QTF-GP, using the latter as the gold standard. STFE had a sensitivity and specificity of 98 % and 86 %, respectively. Next, the positivity and negativity concordance tests were calculated with a confidence interval of 95 %, using the characteristics of each group to differentiate healthy subjects and subjects with TB infection. The total concordance of healthy subjects was 80.00 % for QFT-GP and 75.80 % for STFE, while the total concordance of TB infected subjects was 58.00 % for QFT-GP and 82.00 % for STFE. Conclusion The IGRA test STFE had an improved clinical performance in detecting LTB and TB infected subjects, making it an acceptable alternative to QFT-GP.
-
-
Biobank for Multidrug-resistant Tuberculosis Research: Importance of Sequential Samples
( Jiyeon Kim ),( Yoohyun Hwang ),( Jihye Kang ),( Junghee Lee ),( Seungkyu Park ),( Sungweon Ryoo ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Purpose Since 2013, Masan National Tuberculosis Hospital (MNTH) has collected standardized specimens from its tuberculosis patients, which include a large number of multidrug-resistant strains. The repository collects matched participants and their bacilli samples, compiling sequential samples from the beginning of treatment. The repository aims to provide resources for in-depth international research. Method The MNTH biobank emphasizes on collecting and maintaining specimens from various types of disease-progress in its TB patients. Sputum, serum, urine, and bacterial strains are collected from each patient sequentially, the intervals depending on the condition of each patient. Strains are collected and stored under standardized protocols and stringent biosafety guidelines. Result The majority of specimens collected at MNTH for the past ten years are mostly made up of sputum and blood serum, with 13,196 and 10,905 samples respectively. A total of 1,354 distributions for the internal research institute and 1,022 distributions to external organizations were made as of 2021. The Results and related information are stored in the biobank database, helping form the groundwork in monitoring inpatients’ future treatment outcomes as well as providing future research resources. Analysis of sequential samples has shown a difference in the antibiotic and molecular profiles of the same patient. Currently, the MNTH biobank database stores the Results in the patterns of resistance of TB strains as pDST, molecular diagnosis, and WGS data. Conclusion MNTH presents this unique biobank and its protocols in the hopes that it will be taken as an example of a biorepository operation that may model the future management of TB biobanks. We always welcome infectious sample contributions and distribution requests and hope that our institute’s specimens and our database will allow research projects and clinical trials to become more accessible to all types of pharmaceuticals and medical technology development in our pursuit of the eradication of TB.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
