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Level-Set기반의 화염편 모델을 이용한 가솔린엔진 연소과정 해석
강성모(Sungmo Kang),류종혁(Jonghyuk Ryu),김후중(Hoojoong Kim),김용모(Yongmo Kim),이제형(Je-Hyung Lee) 한국자동차공학회 2006 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
In the present study, the level-set based flamelet approach has been applied to simulate the combustion processes in the homogeneous charge propane-fueled SI engine. The level-set based flamelet approach has the basic advantaged to realistically represent the detailed chemistry with the computational efficiency as well as to properly handle the counter-gradient diffusion. In order to properly account for the spark ignition process, the present model employs the improved discrete particle ignition kernel model, which can treat the spark ignition kernel growth in Lagrangian manner and account for the turbulence effects on ignition kernel growth. Based on numerical results, the detailed discussion has been made for the combustion characteristics of turbulent premixed flames.
Metabolic features of macrophages in inflammatory diseases and cancer
Na, Yi Rang,Je, Sungmo,Seok, Seung Hyeok Elsevier 2018 Cancer letters Vol.413 No.-
<P><B>Abstract</B></P> <P>Macrophages are now considered to be important players in various inflammatory diseases as well as tumor progression. Emerging evidence reveals that macrophage metabolic features are deeply associated with their immune functions. Understanding the interaction between cellular metabolism and immune signaling pathways in macrophages can help us to develop appropriate therapeutic approaches for inflammatory diseases. In this review, we briefly summarize key metabolic features of M1 and M2 macrophages as well as signaling interactions between major metabolic molecules with TLRs and NLRs. Current knowledges of cellular metabolism are focused on macrophages in various disease situations including sepsis, atherosclerosis, obesity, tuberculosis and cancer. Novel insights and present targets for regulating macrophage metabolism are also discussed.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pre-established glycolytic capacity determines inflammatory functions of GM-CSF derived macrophages. </LI> <LI> LPS/IFNγ induces aerobic glycolysis but IL-4/IL-13 potentiates mitochondrial respiration in macrophages. </LI> <LI> AMPK, mTOR and mitochondrial ROS integrate with pattern recognition receptor signaling pathways. </LI> <LI> Key metabolic changes of macrophages were reviewed focused on the inflammatory diseases and cancer. </LI> </UL> </P>
Jeon, Bo-Young,Kim, Seung-Cheol,Je, Sungmo,Kwak, Jeongyeon,Cho, Jang-Eun,Woo, Jong-Tae,Seo, Sangkyo,Shim, Hang-Sub,Park, Byoung-Ok,Lee, Sung-Sik,Cho, Sang-Nae Elsevier 2010 Research in veterinary science Vol.88 No.3
<P><B>Abstract</B></P><P>An enzyme-linked immunosorbent assay (ELISA) using bulk tank milk samples was evaluated as a screening test for bovine tuberculosis (TB), a contagious chronic disease of cattle. An ELISA with MPB70, a major antigen of <I>Mycobacterium bovis</I> was performed using paired sets of milk and sera samples from 33 tuberculin-positive and 43 tuberculin-negative cattle. Anti-MPB70 antibodies were detected in milk samples and there was a significant correlation between seroreactivities of milk and sera samples (<I>R<SUP>2</SUP></I>=0.83). Using the tuberculin skin test as the reference test, the sensitivities of ELISA using milk and sera samples were 87.8% and 81.8%, respectively, and the specificities were 97.7% and 100%, respectively.</P><P>In the screening test using bulk tank milk samples from 931 dairy herds in Whasung, Gyeonggi-do, Korea, the positive rate for anti-MPB70 antibody was 4.5% (42/931) and the tuberculin-positive rate was 2.8% (26/931). Individual milk samples (<I>n</I>=253) were collected from randomly selected 8 problematic and 3 negative herds (positive and negative in the screening test by MPB70 ELISA using bulk tank milk samples, respectively) and tested by MPB70 milk ELISA. In the problematic herds, positive rates were 10.5% (20/190) for anti-MPB70 antibodies in milk ELISA and 2.1% (4/190) in the tuberculin skin test. More than one dairy cows were positive by milk ELISA among the problematic herds, and all tuberculin-positive dairy cows were positive in the milk ELISA. Further, no positive cows were detected in negative herds both by milk ELISA and tuberculin skin test. These results suggest that an ELISA, using bulk tank milk samples, might be a potential efficient screening test for bovine TB of dairy cows.</P>