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A Pervasive Network Control Algorithm for Multicamera Networks
Sungjin Lee,Inwoong Lee,Seonghyun Kim,Sanghoon Lee,Bovik, Alan Conrad IEEE 2014 IEEE SENSORS JOURNAL Vol.14 No.4
<P>Owing to the increasingly large volume and complexity of captured videos, renewable energy systems based on solar energy are of particular interest in the design of energy harvesting (EH) wireless visual sensor networks (WVSNs). Since additional energy consumption following image capture occurs owing to image processing, mote operation, data transmission, and reception, the capture rate significantly affects the lifetime of a node. To this end, we explore a novel energy-efficient framework for EH-WVSN design by developing an optimal algorithm named capture rate and pervasive network control for multicamera networks where the quality of service is maximized by obtaining optimal values for the capture rate, allocated energy, and transmit power, based on field of view-based networking in the presence of event and power acquisition patterns. Through simulations, we demonstrate the feasibility of EH-WVSNs in terms of energy consumption, energy allocation, and capture rate in a realistic scenario (parking surveillance).</P>
Lee, Sungjin,Lee, Ae-Ree,Ryu, Kyoung-Seok,Lee, Joon-Hwa,Park, Chin-Ju Academic Press 2019 Journal of molecular biology Vol.431 No.4
<P><B>Abstract</B></P> <P>Bloom syndrome protein (BLM) is one of five human RecQ helicases that participate in DNA metabolism. RecQ C-terminal (RQC) domain is the main DNA binding module of BLM and specifically recognizes G-quadruplex (G4) DNA structures. Because G4 processing by BLM is essential for regulating replication and transcription, both G4 and BLM are considered as potential targets for anticancer therapy. Although several studies have revealed the detailed mechanism of G4 unwinding by BLM, the initial recognition of the G4 structure by the RQC domain is unclear. Here, we investigated the interaction between BLM RQC and the G4 DNA from the c-Myc promoter by NMR spectroscopy. While the signals broadened upon reciprocal titrations, the β-wing of RQC had significant chemical shift perturbations and experienced millisecond timescale dynamics upon G4 binding. A point mutation in the β-wing (N1164A) reduced G4 binding affinity. Our hydrogen–deuterium exchange data indicate that imino protons of G4 were exchanged with deuterium much faster in the presence of RQC. We suggest that RQC binds to G4 by using the β-wing as a separating pin to destabilize the G4. By providing information about the RQC–G4 interaction, our study yields insight into potential strategies for preventing G4 processing by BLM.</P> <P><B>Highlights</B></P> <P> <UL> <LI> RecQ C-terminal (RQC) domain of Bloom syndrome protein (BLM) binds to the G-quadruplex with micromolar <I>K</I> <SUB>d</SUB>. </LI> <LI> β-wing and α2 region of the RQC domain play an important role in the G-quadruplex interaction. </LI> <LI> BLM RQC domain destabilizes G-quadruplex without the helicase domain of the protein. </LI> <LI> Our results contribute to the understanding of the initial G4 recognition process of BLM. </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
이성진(Sungjin Lee),이청재(Cheongjae Lee),이근배(Gary Geunbae Lee) 한국정보과학회 언어공학연구회 2007 한국정보과학회 언어공학연구회 학술발표 논문집 Vol.2007 No.10
본 논문에서는 영어 회화 교육을 위한 예제 기반 대화 시스템에 대해 논한다. 기존의 획일적인 멀티미디어 영어 학습에서 벗어나 자연어 처리 및 대화 기술을 이용하여 지능적인 일대일 영어 회화 교육 제공을 목적으로 한다. 본 시스템은 미숙한 학습자 발화를 이해할 수 있으므로 불완전한 언어 구사 능력으로도 대화를 참여할 수 있는 체험형 학습을 제공한다. 이를 통해 학습자에게 영어를 배우려는 흥미로운 동기를 부여한다. 또한 학습자의 표현력 향상을 위한 교육적인 도움 기능을 갖추고 있다. 이를 위해 우리는 학습자의 미숙한 표현을 이해하는 통계 기반의 언어 이해 모듈, 도메인 확장성이 뛰어난 예제 기반 대화관리 모듈, 교육 및 평가 기능을 개발하였다.
이성진(Sungjin Lee),이청재(Cheongjae Lee),이근배(Geunbae Lee) 한국정보과학회 2010 정보과학회논문지 : 소프트웨어 및 응용 Vol.37 No.2
본 논문에서는 영어 회화 교육을 위한 예제 기반 대화 시스템에 대해 논한다. 기존의 획일적인 멀티미디어 영어 학습에서 벗어나 자연어 처리 및 대화 기술을 이용하여 지능적인 일대일 영어 회화 교육제공을 목적으로 한다. 본 시스템은 미숙한 학습자 발화를 이해할 수 있으므로 불완전한 언어 구사 능력으로도 대화를 참여할 수 있는 체험형 학습을 제공한다. 이를 통해 학습자에게 영어를 배우려는 흥미로운 동기를 부여한다. 또한 학습자의 표현력 향상을 위한 교육적인 도움 기능을 갖추고 있다. 이를 위해 우리는 학습자의 미숙한 표현을 이해하는 담화 상황 고려 발화의도 인식 모델, 도메인 확장성이 뛰어난 예제기반 대화 관리 모델, 교육 및 평가 기능을 개발하였다. 실험 결과 학습자의 발화에 에러가 많아도 높은 발화의도 인식 성능을 보였으며 대화 상황에 적합한 피드백을 제공하여 학습자가 회화 연습을 끝까지 마치도록 도와 교육 효과에 이바지함을 알 수 있었다. In this paper, we present an Example-based Dialogue System for English conversation tutoring. It aims to provide intelligent one-to-one English conversation tutoring instead of old fashioned language education with static multimedia materials. This system can understand poor expressions of students and it enables green hands to engage in a dialogue in spite of their poor linguistic ability, which gives students interesting motivation to learn a foreign language. And this system also has educational functionalities to improve the linguistic ability. To achieve these goals, we have developed a statistical natural language understanding module for understanding poor expressions and an example-based dialogue manager with high domain scalability and several effective tutoring methods.
US28, a Virally-Encoded GPCR as an Antiviral Target for Human Cytomegalovirus Infection
( Sungjin Lee ),( Yoon Hee Chung ),( Choongho Lee ) 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.1
Viruses continue to evolve a new strategy to take advantage of every aspect of host cells in order to maximize their survival. Due to their central roles in transducing a variety of transmembrane signals, GPCRs seem to be a prime target for viruses to pirate for their own use. Incorporation of GPCR functionality into the genome of herpesviruses has been demonstrated to be essential for pathogenesis of many herpesviruses-induced diseases. Here, we introduce US28 of human cytomegalovirus (HCMV) as the best-studied example of virally-encoded GPCRs to manipulate host GPCR signaling. In this review, we wish to summarize a number of US28-related topics including its regulation of host signaling pathways, its constitutive internalization, its structural and functional analysis, its roles in HCMV biology and pathogenesis, its proliferative activities and role in oncogenesis, and pharmacological modulation of its biological activities. This review will aid in our understanding of how pathogenic viruses usurp the host GPCR signaling for successful viral infection. This kind of knowledge will enable us to build a better strategy to control viral infection by normalizing the virally-dysregulated host GPCR signaling.
Inter-Cell Resource Coordination Utilizing Macroscopic Diversity for an Uplink OFDMA System
LEE, Sungjin,LEE, Sanghoon,GIL, Gyetae The Institute of Electronics, Information and Comm 2009 IEICE TRANSACTIONS ON COMMUNICATIONS - Vol.92 No.10
<P>An ICI (Inter-Cell Interference) mitigation algorithm for exploiting macroscopic diversity for an up-link OFDMA (Orthogonal Frequency Division Multiple Access) system is proposed. To reduce the influence of carrier collision, the order of resource allocation is coordinated based on the location of each MS (Mobile Station) and the associated carrier group. This consideration significantly reduces ICI and enhances throughput at the boundary region.</P>