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( Sung Mo Kim ),( Se Ra Kim ),( Heon Oh ),( Jung Ah Yang ),( Sung Kee Jo ),( Myung Woo Byun ),( Sung Tae Yee ) 한국수의병리학회 2000 학술대회 Vol.2000 No.-
We perfornlecl this stucly to determine the effect of BLI-Zhong-Yi-Qi-Tang, as a prescription of traditional Oriental medicine, and its major ingreclients 011 jejunal crypt s~u-vival, enclogenous spleen colony formation, and apoptosis in jejunal crypt cells of mice irracliatecl with high ancl low close of 7 -racliation. Bu-Zhong-Yi-Qi-Tang aclinii~istration before irradiation protected the jejunal crypts (p<0.0001), increased the formation of endogenous spleen colony (p<0.05) and reduced the frecluency of radiation-ind~~cecal poptosis (p<0.05). In the experiment on the effect of ingreclients of Bu-Zhong-Yi-Qi-Tang, the result indicated that the extract of Rensan (Panax ginseng), Danggui (Radix Angelicae sinensis), Shengma (Rhizoma Cimicifugae) ancl Chaihu (Raclix Bupleuri) might have a major radioprotective effect. Although the mechanisms of this inhihitory effect remain to he elucidated, these results inclicatecl that Bu-Zhong-Yi-Qi-Tang might be a useful radioprotector, especially since it is a relatively nontoxic natural product. Further studies are needed to characterize better the protective nature of Bu-Zhong-Yi-Qi-Tang extract ancl its ingreclients.
Microbiological survey of Korean animal facilities from 2014 to 2019
Sang woon Kim,Hi jo SHIN,Se hee PARK,Teak chang LEE,Hae jin LEE,Ok sung MOON,Ki hoan NAM,Won kee YOON,Hyoung chin KIM,Hyo jung KWON,Young Suk WON 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
To survey the mouse microbiological contamination rate in Korean animal facilities, we tested for common contaminants in these facilities using serological, culture, and parasitological methods. A total of 21,292 experimentally housed mice from 206 animal facilities, including hospitals, universities, companies and research institutes, were tested over a 6-year period from 2014 to 2019. The most commonly found contaminants were various species of non-pathogenic protozoa (47.2%). The most common pathogenic bacteria were Staphylococcus aureus (21.2%), Pasteurella pneumotropica (12.5%) and Pseudomonas aeruginosa (5.8%). Mouse hepatitis virus (6.1%) was detected, but no other viral or bacterial pathogens were found. These results establish that the main pathogens that currently contaminate animal facilities in Korea are opportunistic pathogens, whereas important such as those in categories B or C, were decreased.
( Kee Wook Jung ),( Min Woo Jo ),( Seon Ha Kim ),( Woo Seung Son ),( Hyo Jeong Lee ),( Dong Hoon Yang ),( In Ja Yoon ),( So Young Seo ),( Hyun Sook Koo ),( Ji Beon Kim ),( Sang Hyoung Park ),( Kyung J 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Previous studies using Short Form-36 (SF-36) and Patient Assessment of Constipation Quality of Life (PAC-QOL) have shown a reduced quality of life (QOL) in patients with chronic constipation. However, these questionnaires were composed of more than 26 items, and these surveys taken at outpatient clinics were time-consuming. European Quality of Life-5 Dimensions (EQ-5D) is composed of 5 dimensions with 3 levels measuring people`s utility. However, the psychometric properties of EQ- 5D in chronic constipation have not been evaluated. We aimed to investigate the validity and reliability of EQ-5D and compare them with those of PAC-QOL and SF-36 in women with chronic constipation. Methods: Constipated 150 women (54 ± 16 years) who visited a constipation clinic were prospectively enrolled. They were asked to fi ll in bowel- and QOL-related questionnaires. Construct validity was examined by determining the difference betweenthe EQ-5D indexes among the questionnaires. In addition, differences in the EQ-5D index on the PAC-QOL score were analyzed. Results: The mean duration of constipation and the use of laxatives were 15.1 ± 13.6 years and 6.7 ±8.3 years, respectively. The EQ-5D index showed signifi cant differences in age, education, and comorbidities (all P< 3 times of bowel movement/week) than those with a higher frequency of defecation (= 3 times of bowel movement/week) (P Conclusions: The EQ-5D appears to be effective in measuring QOL in patients with chronic constipation. EQ-5D can be complementary to the previously used PAC-QOL and SF-36 in outpatient clinic settings.
Kee-Hwan Kim,Sang Chul Lee,Sang Kuon Lee,Byung-Jo Choi,Wonjun Jeong,Say-June Kim 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.91 No.2
Purpose: As several years have passed since the implementation of the Korean diagnosis-related group (DRG) payment system for appendicitis, its early outcomes should be assessed to determine if further improvements are warranted. Methods: We retrospectively analyzed clinical data from Korean patients who underwent appendectomy, dividing the sample into 2 groups of those who received services before and after implementation of the DRG system. Based on the DRG code classification, patient data were collected including the amount of DRG reimbursement and the total in-patient costs. We subsequently performed univariate and multivariate analyses to identify independent factors contributing to higher total in-patient cost. Results: Although implementation of the DRG system for appendicitis significantly reduced postoperative length of stay (2.8 ± 1.0 days vs. 3.4 ± 1.9 days, P < 0.001), it did not reduce total in-hospital cost. The independent factors related to total in-hospital cost included patient age of 70 years or more (odds ratio [OR], 3.214; 95% confidence interval [CI], 1.769–5.840; P < 0.001) and operation time longer than 100 minutes (OR, 3.690; 95% CI, 2.007–6.599, P < 0.001). In addition, older patients (≥70 years) showed a nearly 10 times greater relative risk for having a comorbid condition (95% CI, 5.141–20.214; P < 0.001) and a 3.255 times greater relative risk for having higher total in-hospital cost (95% CI, 1.731–6.119, P < 0.001). Conclusion: It appears that older patients (>70 years) have greater comorbidities, which contribute to higher inpatient costs. Thus, our study suggests that patient age be considered as a DRG classification variable.
Influence of Gestational Age at Exposure on the Prenatal Effects of Gamma-Radiation
( Sung Ho Kim ),( Jong Hwan Lee ),( Heon Oh ),( Se Ra Kim ),( Sung Kee Jo ) 한국수의병리학회 2000 학술대회 Vol.2000 No.-
T11e objective of this investigation was to evaluate of influence of gestational age at exposure on the prenatal effects of gcmima-radiation. Pregnant ICR mice were exposed to single dose of 2.0 Gy gamma-radiation at gestation days from 2.5 to 15.5 days post-coitus. he aninids were sacrificed on day 18 of gestation ancl the fetuses were examined for mortality, growth retardation, change in heacl size ancl any other morphological alInormalities. The only den~onstrable effect of irradiation during the pre-implantation period was an increase in prenatal mortality. Resorptions were maximal after exposure on clay 2.5 atfter conception. The pre-implantation irradiated embryos which survived did not show any major fetal abnormalities. Small head, growth retardation, cleft palate, dilatation of cerebral ventricle, clilatation of renal pelvis and al~uormalities of the extremities and tail were prominent after exposure during the organogenesis period, especially on day 11.5 of gestation. The result indicated that the late period of organogenesis in the mouse is a particularly sensitive phase in the development of brain, sltull and extremities.