듀얼 BLAC모터가 적용된 레일 트랙션 시스템의 곡선 주행 성능 개선

옥상재(Sang-Jae Ok),배종남(JongNam Bae),이동희(Dong-Hee Lee) 대한전기학회 2021 대한전기학회 학술대회 논문집 Vol.2021 No.5

외란 관측기를 이용한 듀얼 모터 레일 트랙션 시스템의 위치제어

조기완(Kiwan Cho),옥상재(Sang-Jae Ok),이동희(Dong-Hee Lee) 대한전기학회 2020 대한전기학회 학술대회 논문집 Vol.2020 No.10

한국인 제2형 당뇨병 환자에 대한 디펩티딜 펩티다제 4 억제제 중 Sitagliptin과 Vildagliptin의 약물 사용 평가

이옥상(Ok Sang Lee),임성실(Sung Cil Lim),박현정(Hyun Jung Park) 大韓藥學會 2012 약학회지 Vol.56 No.2

Type 2 Diabetes Mellitus (T2DM) is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. Diabetes is often initially managed by increasing exercise and dietary odification. As the condition progresses, medications may be needed such as oral sulfonylurea or others. Recently, dipeptidyl peptidase 4 (DPP-4) Inhibitor is new drug which can control blood glucose by increasing the active levels of incretin hormone in the body. However, researches have been carried out for mostly Caucasian and Japanese, not for Koreans at all. Therefore, this study was to evaluate the efficacy and safety of DPP-4 inhibitor (Sitagliptin, Vildagliptin) in patients with T2DM in Koreans. This study was carried out retrospectively with reviewing of medical records from the 141 patients who received sitagliptin or vildagliptin over 24 week periods from January 2009, to December 2009. Information including demographics, concomitant medication, disease duration, and exercise was evaluated. HbA1c, random blood glucose, post prandial 2 hour glucose, blood pressure, AST, ALT, serum creatinine, total cholesterol, triglyceride levels were also collected at baseline and endpoint (at 24 weeks). In each post-treatment group, HbA1c, random blood glucose and post prandial 2 hour glucose levels were decreased significantly from baseline in the sitagliptin group (-0.82%, -28.76 mg/dl, -46.65 mg/dl) and vildagliptin group(-1.22%, -27.96 mg/dl, -67.2 mg/dl). Greater HbA1c mean reductions from baseline to 24 weeks were seen in patients with higher baseline values (>7.0%), with shorter disease durations (≤1 year) compared with those with lower baseline values (1 year) in both sitagliptin and vildagliptin groups. The incidences of hypoglycemia, headache and upper respiratory infection were 0%, 8.7%, 5.8% in sitagliptin group and 2.8%, 8.3%, 6.9% in vildagliptin group. In conclusion, our results showed DPP-4 inhibitor provided similar efficacy compared with sulfonylurea after 24 weeks of treatment and were safer than sulfonylurea in hypoglycemia for Korean T2DM. Also vildagliptin was associated with significant improvement in HbA1c reduction in Korean patient with subgroup (body mass index

한국인의 항결핵제에 의한 간독성 위험인자 예측

이지선,김현아,조은,이옥상,임성실,Lee, Ji-Sun,Kim, Hyun-Ah,Cho, Eun,Lee, Ok-Sang,Lim, Sung-Cil 대한약학회 2011 약학회지 Vol.55 No.4

Standard combination chemotherapy including isoniazid, rifampin, pyrazinamide, and ethambutol is very effective against tuberculosis. But, these medicines can cause hepatotoxicity which is the main reason for treatment interruption or change in drug regimen. In order to identify risk factors associated with hepatotoxcity in Koreans and assess elevated baseline LFTs' contributions to hepatotoxicity, a retrospective case control study was performed. The medical records of 277 patients who diagnosed with tuberculosis at a community hospital from January 1st, 2007 to June 30th, 2010 were reviewed. Patients were categorized into 3 groups (non toxic group, patients without increase in LFT levels; mild to moderate hepatotoxic group and severe hepatotoxic group). And the correlation between risk factors and hepatotoxicity was analyzed by using SPSS program. The overall incidence of hepatotoxicity was 18% and 8.7% of patients developed severe toxicity. Patients in the severe toxic group had the longest treatment period among the three groups. In 75% of severe toxic group, hepatotoxicity occurred within 18.3 days after starting medication. Hypoalbuminemia (serum albumin <3 g/dl) was a significant risk factor for development of severe toxicity. Elevated baseline transaminase (except ALT), total bilirubin, and preexisting hepatitis were also risk factors which were more than twice as likely to increase risk of severe hepatotoxicity (p>0.05). In conclusion, hypoalbuminemia (serum albumin level <3 g/dl) was a significant risk factor for anti-tuberculosis druginduced severe toxicity. Therefore, before starting antituberculosis chemotherapy, serum albumin level should be assessed at baseline. In high-risk patients (hypoalbuminemia, elevated LFTs) for hepatotoxicty, liver function should be closely monitored up to at least 21 days after taking medication.

Evaluation of Factors affecting Therapeutic Differences of Antihypertensive Drugs of Korean Patients.

이옥상, 임성칠 충북대학교 약품자원개발연구소 2012 약학논문집 Vol.27 No.-

Background: Hypertension should be controlled well because of its complications related to cardiovascular diseases and hypertensive patients are treated by both pharmacotherapy and lifestyle modification. Though, it is difficult for patients to maintain normal blood pressure evenly due to a variety of response to antihypertensive drug. In order too study which factors may cause therapeuic differences of antihypertensive agents, we evaluated blood pressure, monitoring parameter in western medicine, among patients taking Angiotensin Ⅱ Receptor Blocker or Calcium Channel blocker commonly used in Korea. Methods: From April 2006 to June 2012, we retrospectively studied hypertensive patients in Kyunghee University Hospital at Gangdong. We collected information regarding sex, age, sasang consitution classification, antihypertensive drugs (Angiotensin Ⅱreceptor blocker; ARB, Calcium channel blocker; CCB, ARB+CCB), blood pressure by reviewing electronic medical record. Patients not having blood pressure (base of follow-up) or changing to other classes of antihypertensive drugs during follow-up were excluded. Statistical analysis was used by SPSS (Ver.12.0) and Microsoft Excel 2007. P values less than 0.05 were statistically significant. Results: We selected total 573 patients. CCB was the most used in all groups. Baseline BP was higher in respectively So-yang, femlae and over 65 years groups. BP reduction in 1 month after staring medication between female and male was Female (ARB: -12.9/-3.7, CCB: -10.9/-5.0, ARB+CCB: -19.7/-7.3), Male (ARB: -9.5/-1.6, CCB: -13.5/-6.2, ARB+CCB: -16.2/-7.8) (Drug (P ≤ 0.05/ P ≤0.05), Sex (P >0.05/ P>0.05)). Reduction in blood pressure between under 65 years and over 65 was under 65 years (ARB: -10.5/-5.0, CCB: -10.8/-5.7, ARB+CCB: -12.1/4.9), over 65 years (ARB: (-10.5/-1.3, CCB: -12.5/-4.3, ARB+CCB: -23.3/-8.9) (Drug (P≤0.05/ P>0.05), Age (P>0.05/ P>0.05)). Conclusion: According to our study results, differences of reduction in blood pressure were caused by age, gender, However, further larger scale or prospective studies are required in order to confirm these results.

材料에 따른 Slacks의 着用感에 관한 硏究

李貞淑,咸玉相 한국의류학회 1982 한국의류학회지 Vol.6 No.2

This study was conducted to examine the relation between the clothing materials and the garment's ease under wearing condition. Wearing test of slacks in the same pattern which were made of 3 woven fabrics and 1 knitted fabric have been carried out. Subjects were 5 female students. Some physical properties of these fabrics were investigated. The following results were obtained. 1. By analysis variance with the results of sensory test which was tested by paired comparison method, it was obtained that the effect of materials on the garment's ease were significant at the 1% level on every part of slacks and posture of subiect. It indicates that there is a difference of materials from materials in garment's ease. 2. Significant at the 5% level among the materials. Jersey and Jean were lcoser than the other two materials. Clothing materials have., considerable effect on the garment's ease of slacks, therefore it was noticed that the ease of slacks must have ccnsidered the clothing materials. It is more necessary in working dress. 3. Elastic recovery of width was more contributive to garment's ease of slacks than any other physical properties.