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김선미(Sun Mie Kim),김건우(Kun Woo Kim),이정렬(Jung Ryeol Lee),이효표(Hyo Pyo Lee),강순범(Soon Bum Kang) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.2
We report two cases of adenoid cystic carcinoma of Bartholin's gland. One of these patients had positive margin on operation and is scheduled for adjuvant radiotherapy. The other was first diagnosed 13 years ago and presented with her second recurrence without distant metastasis. Adenoid cystic carcinoma of the Bartholin's gland is a rare tumor of the vulva. When diagnosed, the treatment should be individualized to the patient. When the surgical margin is found to be positive, adjuvant radiotherapy seems to be beneficial.
김선미 ( Sun Mie Kim ),( Seok Hyun Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Joong Yeup Lee ),( Ki Chul Kim,Md ),( Do Yeong Hwang ),( Jung Gu Kim ),( Shin Yong Moon ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Objective: To assess the effi ciency of anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, antral follicle count (AFC), endometrial thickness (EMT), and clinical fi ndings as predictive markers of menopause in late reproductive-aged Korean women. Methods: A cohort of 104 women, aged 45 to 55 years in their menopausal transition were selected. The participants were assessed twice (T1 and T2) at a mean interval of 13.1 months. At each time, their menstrual history was determined; pelvic ultrasonography was performed to evaluate AFC and EMT; blood sampling was done. A logistic regression analysis using the SPSS ver. 17.0 was performed, with the outcome measure of menopause at T2. Results: Of the 104 participants, 33 were postmenopausal based on their menstrual history at T2. Compared with women who stayed in the menopausal transition period, those who became postmenopausal at T2 differed signifi cantly with regard to the following factors at T1: FSH, estradiol, EMT, AFC, days from the last menstrual cycle, and interval between the last 2 cycles. However, AMH levels were not different between the groups. Of all the parameters, a longer number of days from the last menstrual cycle and time interval between the last 2 cycles were signifi cantly associated with the occurrence of menopause. Conclusion: This study indicates that AMH is not a predictive marker of menopause in late reproductive-aged women over a relatively short timeframe (range, 0.5 to 2.5 years). Time since the last menstruation at T1 was a better predictor of menopause.
증례 : 호흡기 ; 폐암 진단 과정 중 발견된 기도 내 연골종 1예
임선미 ( Sun Mie Yim ),강지영 ( Ji Young Kang ),강현희 ( Hyeon Hui Kang ),이수연 ( Soo Yeon Lee ),김경희 ( Kyung Hee Kim ),최수진 ( Su Jin Choi ),이상학 ( Sang Haak Lee ) 대한내과학회 2012 대한내과학회지 Vol.82 No.3
Tracheal chondromas are very rare benign cartilaginous tumors. We present the first case report, to our knowledge, of a tracheal chondroma in Korea. A 73-year-old male was referred to our hospital for a mass in the left lung. Flexible bronchoscopy was performed to evaluate the lung mass and incidentally found a tracheal mass as well. A biopsy and histological examination of the tracheal mass revealed a chondroma. (Korean J Med 2012;82:352-356)
PARK, SUN HEE,KIM, KYU-WON,LEE, YONG SOO,BAEK, JIN HYEN,KIM, MYOUNG SOOK,LEE, YOU MIE,LEE, MI SOOK,KIM, YUNG-JIN 부산대학교 유전공학연구소 2001 분자생물학 연구보 Vol.17 No.-
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor that plays a central role in angiogenesis. In this study, we investigated the mechanism of VEGF expression in HepG2 human hepatoblastoma cells under hypoglycemia. The shortage of glucose significantly enhanced VEGF mRMA expression in a time-dependent manner as well as increased DNA-binding activity of AP-1 that plays an important role in VEGF transcription. In addition, treatment of a potent PKC inhibitor, H-7 in glucose-deprived HepG2 cells suppressed hypoglycemia-elevated VEGF expression as well as the increased AP-1 DNA-binding activity. Moreover, we observed that Ca^2+ levels remarkably increased under low glucose condition. Consistently, an intracellular Ca^2+ chelator, BAPTA/AM significantly decreased hypoglycemia-induced VEGF expression and AP-1 DNA-binding activity. Therefore, these results indicate that increase of intracellular Ca^2+ level induces the activation of PKC, which induce the activation of AP-1 leading to the increase of VEGF in glucose-deprived environment. Furthermore, it provides ond link in regulation of VEGF with hypoglycemia as well as information to understand how hypoglycemia induces VEGF expression and subsequently leads to tumor angiogenesis.
김선미 ( Sun Mie Kim ),김석현 ( Seok Hyun Kim ),이정렬 ( Jung Ryeol Lee ),지병철 ( Byung Chul Jee ),서창석 ( Chang Suk Suh ),이중엽 ( Joong Yeup Lee ),김기철 ( Ki Chul Kim ),황도영 ( Yeong Hwang ),김정구 ( Jung Gu Kim ),문신용 ( S 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.2
목적: 폐경이행기 한국 여성에서 폐경 예측 지표로서 혈중 anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, 자궁내막 두께, 초음파상의 동난포 개수 및 임상적 증상들의 유용성을 평가하고자 하였다. 연구방법: 45-55세 사이의 폐경이행기 여성 104명이 참여하였으며 평균 13.1개월 간격으로 두 번에 걸쳐 방문하였다. 각 방문 시 최근의 월경력을 확인하고 골반 초음파검사를 시행하여 동난포 개수 및 자궁내막 두께를 측정하였으며 호르몬검사를 위한 혈액을 채취하였다. 최종 평가 지표는 두 번째 방문(T2) 시의 폐경 여부였으며 통계적 분석은 SPSS ver. 17.0을 사용하였다. 결과: 104명의 참여자 중 두 번째 방문시기에 폐경이 된 여성은 33명이었다. 두 번째 방문 시 폐경된 여성들은 그렇지 않은 여성들과 비교하여 첫 번째 방문 시의 FSH, estradiol, 자궁내막 두께, 동난포 개수, 최종 월경일로부터 경과일 및 최종 월경일과 그 이전 주기와의 기간에 있어 유의한 차이를 보였다. 그러나 AMH 수치는 두 그룹 간 유의한 차이를 보이지 않았다. 모든 인자들 중 최종 월경일로부터 경과일 및 최종 월경일과 그 이전 주기와의 간격이 폐경 발생과 유의한 상관관계를 보인 지표였다. 결론: 폐경이행기 여성에서 1년 정도의 짧은 간격을 두고 볼 때 AMH는 폐경을 예측하는 지표가 되지 못하였다. 첫 번째 방문 시 최종 월경일로부터 경과한 기간이 1년 후 폐경 예측의 더욱 유용한 지표이다. Objective: To assess the efficiency of anti-Mullerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, antral follicle count (AFC), endometrial thickness (EMT), and clinical findings as predictive markers of menopause in late reproductive-aged Korean women. Methods: A cohort of 104 women, aged 45 to 55 years in their menopausal transition were selected. The participants were assessed twice (T1 and T2) at a mean interval of 13.1 months. At each time, their menstrual history was determined; pelvic ultrasonography was performed to evaluate AFC and EMT; blood sampling was done. A logistic regression analysis using the SPSS ver. 17.0 was performed, with the outcome measure of menopause at T2. Results: Of the 104 participants, 33 were postmenopausal based on their menstrual history at T2. Compared with women who stayed in the menopausal transition period, those who became postmenopausal at T2 differed significantly with regard to the following factors at T1: FSH, estradiol, EMT, AFC, days from the last menstrual cycle, and interval between the last 2 cycles. However, AMH levels were not different between the groups. Of all the parameters, a longer number of days from the last menstrual cycle and time interval between the last 2 cycles were significantly associated with the occurrence of menopause. Conclusion: This study indicates that AMH is not a predictive marker of menopause in late reproductive-aged women over a relatively short timeframe (range, 0.5 to 2.5 years). Time since the last menstruation at T1 was a better predictor of menopause.
Time Use Analysis of Married Paid Workers by Employment Types
Hyun-Ah Lee,Hee-Keum Cho,Seung-Mie Lee,Young-Sun Han 한국유통과학회 2016 Asian Journal of Business Environment (AJBE) Vol.6 No.2
Purpose – This study aims to analyze time use of employees to see how they make a balance between work and family. We tried to analyze time use and time pressure of married paid workers in order to understand their work and family balance. Methodology – Time use was compared by employment types and time pressure groups. We analyzed the factors influencing time pressure, dividing two employment types. The data were selected from the 2009 Korean Time Use Survey. Results – Those who feel time pressure among full-timers spent more time on work and housework and less time on personal care and leisure than those who do not feel time pressure. Logit analysis on time pressure showed that full-timers feel more time pressure than part-timers do. Gender, age, education, income, day-off type, and the presence of preschool children were significant variables on time pressure. Conclusion – These results imply that time use and time pressure for married paid workers are affected by employment types. Flexibility of labor needs to enhance work and family balance for females who have preschool children.
결핵성 공동으로 오인된 외상 후 발생한 가성 폐낭종 1예
이현정 ( Hyun Jeong Lee ),강지영 ( Ji Young Kang ),임선미 ( Sun Mie Yim ),지은혜 ( Eun Hye Ji ),김지현 ( Ji Hyun Kim ),김세원 ( Sei Won Kim ),이상학 ( Sang Haak Lee ),문화식 ( Hwa Sik Moon ),이배영 ( Bae Young Lee ) 대한결핵 및 호흡기학회 2009 Tuberculosis and Respiratory Diseases Vol.67 No.5
A traumatic pulmonary pseudocyst is a rare complication of blunt thoracic trauma. The clinical symptoms and signs are similar to other respiratory diseases, such as pulmonary tuberculosis. Therefore, a trauma history with the resulting radiologic and clinical findings is important for making a diagnosis. A 26-year-old male was admitted to our hospital due to cough for 3 days. The chest x-ray revealed diffuse infiltrations and a cavitary lesion at the left lung. His left chest had hit a tree as a result of motorcycle accident one day before admission. Initially, it was assumed that his symptoms and chest X-ray might be due to a tuberculosis infection. However, bronchoscopy revealed old blood clots at both lungs, particularly in the left lower lobe bronchus. A transbronchial lung biopsy showed alveolar hemorrhage. A traumatic pulmonary pseudocyst was diagnosed from his trauma history and these findings. Computed tomography of the chest performed 4 months later showed regression of the cavitary lesion.