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Byeon, Suk Ho,Chu, Young Kwang,Hong, Young Taek,Kim, Min,Kang, Hae Min,Kwon, Oh Woong Lippincott 2012 Retina Vol.32 No.6
PURPOSE:: To describe the pathoanatomy of diabetic macular edema in optical coherence tomography and its correlation with fluorescein angiography patterns. METHODS:: Sixty eyes of 56 patients were analyzed. Diabetic macular edema was classified into typical focal leakage (from microaneurysm), typical diffuse leakage (the capillary plexus), or combined/questionable leakage using fluorescein angiography and retinal thickness profiles. The leakage and pooling patterns in fluorescein angiography were matched to the corresponding optical coherence tomography images and analyzed. RESULTS:: Focal leakage shows swelling predominantly in the outer plexiform layer (OPL). Deeply located microaneurysms directly leak into the loose fiber portion of OPL (Henle layer) through the “fluid conductivity barrier” (synaptic portion of OPL). Diffuse leakage caused swelling predominantly in the inner nuclear layer and secondarily in the OPL. The deep capillary plexus is located between the two “fluid barriers” (inner plexiform layer and OPL); thus, diffuse leakage is primarily related with swelling in the inner nuclear layer. In the combined/questionable leakage, partial sections consisting of inner nuclear layer swelling and much larger areas of OPL/outer nuclear layer swelling are noticed. CONCLUSION:: Based on the concept of the fluid conductivity barrier, we revealed a correlation between the intraretinal location of the leakage source and where the fluid accumulated within the retinal layers.
Choy, Jin-Ho,Choi, Suk-Yong,Byeon, Song-Ho,Chun, Sung-Ho,Hong, Seung-Tae,Jung, Duk-Young,Choe, Won-Young,Park, Yung-Woo Korean Chemical Society 1988 Bulletin of the Korean Chemical Society Vol.9 No.5
The ratio of trivalent to divalent copper has been determined by the redox titration for two superconducting phases of $YBa_2Cu^{3+}_{2x}Cu^{2+}_{3-2x}O_{6.5+x}$ with the onset temp. of 60K (x = 0.23 ${\pm}$ 0.01) and 90K (x = 0.35 ${\pm}$ 0.02), and for the insulating one (x ${\cong}$ 0) which was kept in an ambient atmosphere for 72 hrs. It is found that $T_c$, and the ratio of $Cu^{3+}/Cu^{2+}$ depend strongly on the annealing temperature and time. A typical orthorhombic phase can easily be obtained by a slow cooling or stepwise cooling at $PO_2$ = 1 atm, and shows a high Tc (ca. 90K) superconductivity.
Clinical Features and Prognosis of Resectable Primary Colorectal Signet-Ring Cell Carcinoma
( Ho Su Lee ),( Jae Seung Soh ),( Seohyun Lee ),( Jung Ho Bae ),( Kyung Jo Kim ),( Byong Duk Ye ),( Jeong Sik Byeon ),( Seung Jae Myung ),( Suk Kyun Yang ),( Sun A Kim ),( Young Soo Park ),( Seok Byun 대한장연구학회 2015 Intestinal Research Vol.13 No.4
Background/Aims: We attempted to investigate the prognosis of signet-ring cell carcinoma (SRC) patients who underwent curative surgery by comparing them with age-, sex-, and stage-matched non-mucinous adenocarcinoma (NMAC) patients. Methods: Between January 2003 and December 2011, 19 patients with primary SRC of the colorectum underwent curative surgery. Four SRC patients under the age of 40 were excluded, and the clinicopathological data of 15 patients (7 men; median age, 56 years) were reviewed and compared with the data of 75 NMAC patients matched by age, sex, and pathologic stage. Results: The median follow-up duration was 30.1 months for the SRC group and 43.7 months for the NMAC group (P=0.141). Involvement of the left side of the colon (73.3% vs. 26.7%, P=0.003) and infiltrative lesions such as Borrmann types 3 and 4 (85.7% vs. 24.0%, P=0.001) were more common in the SRC group than in the NMAC group. The five-year overall survival rate was significantly lower for patients with SRC than for those with NMAC (46.0% vs. 88.7%, hazard ratio, 6.99; 95% confidence interval, 2.33-20.95, P=0.001). Conclusions: Patients with even resectable primary colorectal SRC had a poorer prognosis than age-, sex-, and stage-matched colorectal NMAC patients. (Intest Res 2015;13:332-338)
Short- and Long-Term Outcomes of Acute Severe Ulcerative Colitis in Korea : The 1999-2005 Cohort
Lee, Ho-Su,Yang, Suk-Kyun,Soh, Jae Seung,Lee, Seohyun,Bae, Jung Ho,Lee, Hyo Jeong,Park, Sang Hyoung,Yang, Dong-Hoon,Kim, Kyung-Jo,Ye, Byong Duk,Byeon, Jeong-Sik,Myung, Seung-Jae,Yoon, Yong Sik,Yu, Cha Oxford University Press 2015 Inflammatory bowel diseases Vol.21 No.8
<P>No previous studies have evaluated the long-term outcomes of acute severe ulcerative colitis (ASUC) in non-Caucasian populations. The purposes of this study were to evaluate the short- and long-term outcomes of Korean patients with ASUC.</P>
( Sun-ho Lee ),( Sung Wook Hwang ),( Sang Hyoung Park ),( Dong-hoon Yang ),( Jeong-sik Byeon ),( Seung-jae Myung ),( Suk-kyun Yang ),( Byong Duk Ye ) 대한장연구학회 2022 Intestinal Research Vol.20 No.2
Background/Aims: Fecal S100A12 (FS) and serum S100A12 (SS) have been reported as novel biomarkers that accurately reflect intestinal inflammation. We evaluated if FS and SS in comparison to fecal calprotectin (FC) are associated with poor future outcomes in clinically quiescent Crohn’s disease (CD) patients. Methods: We prospectively enrolled 49 CD patients in clinical remission (Crohn’s Disease Activity Index [CDAI] <150 for the past 6 months). Patients were followed for a median period of 4.4 years (interquartile range [IQR], 4.3-4.5). The following outcomes were evaluated: clinical relapse, CD-related hospitalization, step-up of medical treatment, and CD-related intestinal resection. Cox proportional-hazard regression model was constructed to assess the association of baseline markers with time-to-event outcomes. Results: The median levels of baseline FS, FC, and SS were 0.042 mg/kg (IQR, 0.005-0.179), 486.8 mg/kg (IQR, 203.5-886.8) and 1,398.2 ng/mL (IQR, 791.8-2,759.9), respectively. FS correlated with FC (r=0.689), erythrocyte sedimentation rate (r=0.524), C-reactive protein (r=0.499), and albumin (r=-0.446), but not with CDAI (r=0.045). Interestingly, increased FS (top quartile) was associated with a 4.9-fold increased rate of future CD-related hospitalization (P=0.009) and a 2.8-fold increased rate of step-up of medical treatment (P=0.032), whereas increased FC and SS were not. These findings remained significant after adjusting for age, sex, disease duration, current smoking, C-reactive protein, serum albumin, CDAI, and FC, individually. Conclusions: In this pilot study, increased FS and not FC or SS, was significantly associated with increased rates of future CD-related hospitalization and step-up of medical treatment among CD patients in clinical remission. (Intest Res 2022;20:203-212)
( Sun-ho Lee ),( Kiju Chang ),( Ki Seok Seo ),( Yun Kyung Cho ),( Eun Mi Song ),( Sung Wook Hwang ),( Dong-hoon Yang ),( Byong Duk Ye ),( Jeong-sik Byeon ),( Seung-jae Myung ),( Suk-kyun Yang ),( Sang 대한장연구학회 2020 Intestinal Research Vol.18 No.2
Background/Aims: The use of complementary and alternative medicine (CAM) is a global phenomenon, including inflammatory bowel disease (IBD) patients. We aimed to assess the change in prevalence and patterns of CAM use, and attitudes towards CAM over an 8-year time interval (2006 vs. 2014) among IBD patients in Korea. Methods: A total of 221 IBD patients (CD=142, UC=79) were asked to complete a questionnaire regarding CAM at two time points: at enrollment (2006) and 8 years later (2014/2015). Results: The proportion of patients ever using CAM increased significantly from 60.2% in 2006 to 79.6% in 2014 (P<0.001), while the proportion of current CAM users increased slightly (35.7% to 38.0%, P=0.635); 21.7% used CAM consistently at both time points. The proportion of patients who felt CAM was less effective (P<0.001) and more expensive (P=0.04) than conventional treatments increased over time. Also, the proportion among ever CAM users who perceived a positive effect from CAM significantly decreased in 2014 compared to 2006 (P=0.004). Higher education (adjusted odds ratio [aOR], 2.10), prior side effects to conventional therapies (aOR, 2.23), and prior use of corticosteroids (aOR, 2.51) were associated with CAM use. Interestingly, use of CAM before IBD diagnosis (aOR, 2.73) was significantly associated with consistent CAM use. Conclusions: Although the attitudes toward CAM have become less favorable, the majority of IBD patients have experienced CAM with an overall increase of current CAM users over time. Moreover, more than half of current CAM users used CAM consistently over time. (Intest Res 2020;18:192-199)