An Extremely Rare Case of Back and Hip Pain due to the Metastasis of Late Recurrent Myxopapillary Ependymoma to the Inguinal Lymph Node

Suheyla Ekemen,Ozlem Yapicier,Hatice Deniz Boler,Umit Ince 대한병리학회 2018 Journal of Pathology and Translational Medicine Vol.52 No.1

Evaluation of adsorption characteristics of new-generation CNT-based adsorbents: characterization, modeling, mechanism, and equilibrium study

Kocaman Suheyla 한국탄소학회 2023 Carbon Letters Vol.33 No.3

In this study, superior carbon nanotubes (CNT) were chemically modified with itaconic acid (IA) and a polyaniline (PANI) composite was formed and used to remove methylene blue (MB) dye from an aqueous solution. The capacity of CNTs modified with IA (IA/CNT) and composited with PANI (PANI/CNT) to remove MB dye from an aqueous solution was compared and investigated. The effects of parameters such as pH (3–10), adsorbent dose (0.8–8 g/L), initial dye concentration (10–100 mg/L), and temperature (25–55 °C) on MB adsorption were investigated. IA/CNT and PANI/CNT adsorbents were characterized by analyzes such as Fourier Transform Infrared Spectroscopy (FT-IR), Field Emission Scanning Electron Microscopy (FE-SEM), transmission electron microscope (TEM), and Brunauer, Emmett and Teller (BET). It was determined that the isotherm data fit the Langmuir isotherm model. The maximum adsorption capacity (qmax) of PANI/CNT and IA/CNT calculated according to this model (at 25 °C) was 12.78 and 32.78 mg g−1, respectively. Thermodynamic analysis results showed that the adsorption was exothermic, feasible, and spontaneous. It can be said that the possible mechanism of MB on PANI/CNT and IA/CNT adsorbents occurs with the participation of π–π interaction, electrostatic attraction and hydrogen bonding.

Evaluation of EPDM waste in environmentally friendly epoxy hybrid composites

Melisa Temiz,Suheyla Kocaman,Gulnare Ahmetli 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.126 No.-

This study aims to reduce the production cost of composite materials, obtain composite materials withimproved properties, and expand the applications of waste rubber composites using two different industrialwastes, ethylene-propylene-diene monomer rubber (EPDM) and tire waste pyrolysis solid productcarbon black (CB). Composites were formed by adding EPDM waste or EPDM-CB mixture at 1:1, 1:3,and 3:1 ratios to bisphenol-A type epoxy resin in different weight ratios. Mechanical, water sorption,electrical conductivity, and flammability tests were applied to the composites. The effect of the EPDM:CB ratio and some environmental conditions on the mechanical properties of the hybrid composites wereinvestigated. Composites with 3:1 weight ratio of EPDM:CB had the highest tensile strength, which variedbetween 115.5–158.6 MPa. Increasing the EPDM ratio in an epoxy matrix and hybrid filler decreased thecomposites’ density and tensile strength. EPDM-CB hybrid filler increased the thermal strength of epoxy. Mechanical properties are affected by water sorption, low temperature, and UV irradiation. Increasing theCB ratio in the hybrid filler decreased the flammability of the hybrid composites. ANOVA is applied to findthe significant effect of different weight percentages of hybrid fillers and different varieties of fillers onthe mechanical properties of composites.

The Pap-Smear Test Experience of Women in Turkey: A Qualitative Study

Arabaci, Zeynep,Ozsoy, Suheyla Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Objective: The study was planned with the purpose of examining the attitude of women who have pap-smear test for the early diagnosis of cervical cancer, factors affecting their decisions and their feelings and experiences during this period. Materials and Methods: A phenomenological method was used. Data were collected between March 2012 and April 2012 using standard and purposive samplings from 17 women. A detailed interview with women were held in their houses and recorded. The data collection tool consisted of two parts, one of which is information form with 17 questions identifying sociodemographic and cervical cancer risk factors of women and the second part is made up of semi-structured interview form with 15 alternative questions taking literature and the pap-smear test into consideration. Collected data were put into a written document. Content analysis was held by loading the documents into NVIVO 8 Statistical Programme. Results: The study comprised themes such as cervical risk factor, decision of taking pap-smear test, taking pap-smear test, knowledge about pap-smear test, relieving factors during pap-smear test, obstructive factors during pap-smear test, gynecological examination and feelings of women during and after pap-smear test while waiting for the results. Conclusions: As women perceive gynaecological examinations differently from other examinations, they have different feelings in each process of the Pap smear test. Medical staff should advise women more clearly on the nature and advantages of the Pap-smear test.

Palliative treatment of Kaposi sarcoma with radiotherapy: a single center experience

Gonca Altinisik Inan,Ipek Pinar Aral,Suheyla Aytac Arslan,Yilmaz Tezcan 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.1

Purpose: The aim of this study is to evaluate the treatment responses of Kaposi sarcoma patients treated with radiotherapy (RT). Materials and Methods: The data of 18 patients (40 different regions) who were treated for Kaposi sarcoma in Department of the Radiation Oncology, Ankara City Hospital, Turkey between March 23, 2010 to February 13, 2018 were evaluated retrospectively. The primary endpoint of the study was the clinical-subjective response after RT, and the secondary endpoint was the visual response assessment after RT. Results: In evaluating the patients’ reported response of the lesions: 25 (62.5%) of complete response (CR), 12 (30%) of partial response (PR), and stable response was seen in 3 patients (7.5%). Patient reported response after RT was significantly higher in male sex (p = 0.002; odds ratio [OR] = 13.8, 95% confidence interval [CI], 2.7–70.0). Physician reported response rates were available for 28 lesions and CR was detected in 12 lesions (30%); PR was observed in 16 (40%). The relationship between physician reported outcome and RT techniques (electron, bolus, or water bolus) is close to the limit of statically significance (p = 0.052). Fewer lesions disappeared in patients with photon preference than electrons (p = 0.036; OR = 0.093; 95% CI, 0.009–0.950). Patients’ reported complete response rates were significantly higher in the 20 Gy per 5 fractions treatment arm (p = 0.042; OR = 1.75; 95% CI, 1.1–2.7). Conclusion: RT is an effective local treatment with high response rates in the treatment of Kaposi sarcoma. The subjective-clinical response rate was higher in male sex and the visual response was higher in the 20 Gy per 5 fractions arm. Additional studies are needed to standardize RT dose and techniques.

Perineural Invasion Independent Prognostic Factors in Patients with Gastric Cancer Undergoing Curative Resection

Selcukbiricik, Fatih,Tural, Deniz,Buyukunal, Evin,Serdengecti, Suheyla Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

Objective: The prognostic significance of perineural invasion (PNI) in gastric cancer has been previously investigated but not clearly clarified. The objective of our study was to investigate the role of PNI as prognostic factor in patients undergoing curative surgical resection and without distant metastasis in comparison with other clinicopathological factors. Methods: Between 2001 and 2010, 287 cases of gastric adenocarcinoma underwent radical gastrectomy recorded in hospital based registries. PNI was assessed as positive when cancer cells were seen in the perinerium or neural fascicles intramurally. Categorical and continuous variables were summarized using descriptive statistics and compared using chi-square and Mann-Whitney U tests, respectively. Cancer related survival rates were estimated by the Kaplan-Meier method. Results: PNI was positive in 211 of 287 cancers (73%), with a positive relation to lymph node metastases and advanced stage (p=0.0001, p=0.0001, respectively), mural invasion, and lymphatic and blood vessel invasion (p=0.0001, p=0.0001, respectively). The median survival of the PNI positive patients was significantly shorter than that of their PNI negative counterparts (24.1 versus 38.2 months, p=0.008). In the multivariate analysis, we detected PNI was an independent prognostic factor (p=0.025, HR=1.21, 95% CL 1.08-2.3) along with classical clinicopathological variables such as lymph node involvement (p=0.001), pT stage (p=0.03), and LVI (p=0.017), but not age, gender, tumour localization, stage, histologic type, and surgery procedure. Conclusions: PNI positivity in gastric cancers was related mural invasion, lymph node involvement, advanced stage and lymphatic and venous blood vessels. The presence of PNI appeared as an independent prognostic factor on survival on multivariate analysis, not influenced by tumor stage, lymph node metastases and other classical factors.

Is Her-2 Status in the Primary Tumor Correlated with Matched Lymph Node Metastases in Patients with Gastric Cancer Undergoing Curative Gastrectomy?

Selcukbiricik, Fatih,Erdamar, Sibel,Buyukunal, Evin,Serrdengecti, Suheyla,Demirelli, Fuat Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

Background: HER2 expression in the primary tumor and its lymph node metastases vary in gastric cancer, reflecting intratumoral heterogeneity. This finding also suggests that proliferation of a different clone in metastatic nodes is possible. In the current study, we aimed to determine the cause of discordance in HER-2 expression in the primary tumor and lymph node metastases for patients with gastric cancer. Materials and Methods: Eighty-one patients with gastric cancer who had undergone radical gastrectomy and were found to have lymph node metastasis upon pathological examination were included. Histopathological samples were obtained from biopsies obtained during patient gastrectomies and lymph node dissection. HER2 status was evaluated by both immunohistochemistry (IHC) and silver in situ hybridization (SISH). Results: Sixty-four (79%) patients were SISH (-), while 17 (21%) were SISH (+) in the primary tumor. However, in metastatic lymph nodes, HER2 status was SISH positive in 5 (28.3%) of the 64 SISH (-) primary tumor specimens. One of the 17 SISH (+) primary tumors was SISH (-) in the metastatic lymph nodes. Thus, SISH results for HER2 in both primary tumors and lymph node metastases were comparable, showing a concordance of 92.5%. In total, six patients demonstrated discordance between the primary tumor and lymph node metastases. The prevalence of HER2 discordance was significantly higher for patients in the pN2 and N3 stages (p=0.007). Although discordant patients had worse survival rates than concordant patients, the differences were not significant (p>0.05).Conclusions: Our study indicates that the frequency of concordance in HER2 status, as determined by IHC or SISH, is high in primary tumors and their corresponding lymph node metastases for patients with gastric cancer. If there is a discrepancy in HER2 status, its evaluation by both IHC and SISH may be useful for detecting patients who would benefit from trastuzumab, and it would therefore help guide decision-making processes in administering treatment.

The Reflections of Final Year Medical Students About Nursing Home: “Loneliness and Abandonment”

Huseyin Elbi,Selim Altan,Aynur Cakmakci Cetinkaya,Suheyla Rahman 대한노인병학회 2019 Annals of geriatric medicine and research Vol.23 No.2

Background: Population aging is a global phenomenon with opportunities and challenges. The numbers and proportions of older people are increasing in almost every country. This study aimed to evaluate the perceptions of nursing homes among final-year medical stu-dents. Methods: This qualitative study used the word association test as a data collection tool to obtain the reflections regarding nursing homes among final-year students, and the concept of “nursing homes” was defined in face-to-face interviews of the volunteer students. Results: Analysis of data collected from 51 students regarding nursing homes resulted in five main categories (old age [frequency, f=74], positive affect emotions [f=66], negative affect emotions [f=165], loneliness [f=75], and abandonment [f=46]) based on the reflections that the term “nursing home” evoked among the students. In the pres-ent study, the final-year students primarily used more negative expressions. Conclusion: Qualitative studies with students, such as those included in the present study, can provide important clues for the development of educational curriculum and social health policies.

Increase in the Rate of HPV Positive Oropharyngeal Cancers During 1996-2011 in a Case Study in Turkey

Tural, Deniz,Elicin, Olgun,Batur, Sebnem,Arslan, Deniz,Oz, Buge,Serdengecti, Suheyla,Uzel, Omer Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: Primary aim of this study is to assess whether or not there is an increase at rate of HPV positive oropharyngeal cancers during 1996-2011 in Turkey, for comparison with prior reports from Western countries. Materials and Methods: A total of 138 newly diagnosed patients with oropharyngeal cancer were identified, 39 of which had no primary tumor specimen available and 18 patients with invalid HPV status, therefore HPV status for remaining 81 patients was evaluated. The presence and type of HPV DNA were determined with formalin-fixed paraffin embedded specimens, using an HPV DNA-based multiplex PCR assay. Associations between HPV status and clinicopathological characteristics were evaluated using a two-sample t-test for the continuous variables and the categorical variables were compared by chi-square test. Overall survival (OS) periods were calculated with Kaplan-Meier method. Results: The proportion of HPV-positive cancer has continued to increase during 2004-2011 as compared with 1996-2003. Notably, 33% (6/18) of the cases were HPV-positive in 1996-1999, 43% (9/21) in 2000-2003, 55% (11/20) in 2004-2007 and 70% (16/23) in 2008-2011. Thus, when we compared the results obtained during the 2004-2011with results of 1996-2003 period, we found that increase at HPV-positivity ratio was statistically significant (38% vs 64% p=0.012). Conclusions: This study demonstrated that HPV positive oropharyngeal cancers are increasing in Turkish patients as in the Western world.

Is Helicobacter pylori a Poor Prognostic Factor for HER-2 SISH Positive Gastric Cancer?

Selcukbiricik, Fatih,Tural, Deniz,Erdamar, Sibel,Buyukunal, Evin,Demirelli, Fuat,Serdengecti, Suheyla Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Background: Helicobacter pylori (H. pylori) is one of the risk factors for gastric cancer (GC). Any prognostic effect of HER-2 status in gastric lymph node metastasis in H. pylori positive cases is unknown. Materials and Methods: A total of 74 patients, 47 (64%) male, and 27 (34%) female, who had subtotal or total gastrectomy and also positive lymph nodes, were included in the study. Age range was 29-87 years, and median age was 58 years. HER-2 expression was assessed in both gastric resection samples and lymph node material with carcinoma metastasis of the same patient by immunohistochemistry (IHC) and silver in situ hybridization (SISH) methods. H. pylori status was examined in gastric materials of all patients. Relationships between HER-2 status in gastric cancers and lymph nodes and H. pylori status were investigated. Results: H. pylori was positive in 40 cases (54%), and negative in 34 (46%). While in the primary tissues of H. pylori positive cases, SISH positivity for HER-2 was observed in 13 cases (86%), SISH negativity was observed in 2 (14%), in metastatic lymph nodes 21 cases (72%) were SISH positive and 8 cases (28%) were SISH negative (P=0.005 and P=0.019, respectively). Initial CEA values were high in 18 cases (78%) with positive H. pylori and in 5 cases (22%) with negative H. pylori (P=0.009). While SISH data of patients were negative in 59 cases (80%) and positive in 15 cases (20%) in primary tissues, they were negative in 56 cases (75%) and positive in 18 cases (25%) in lymph nodes. Discrepancy between primary tissue and lymph node results was detected in 3 cases, in which SISH was negative in the primary tissue and HER-2 expression was positive in the lymph nodes. Conclusions: Clinical progression was poor in H. pylori positive cases with HER-2 negativity in primary gastric tissue, but HER-2 positivity in the lymph nodes. SISH positivity can be expected in H. pylori positive cases, and it may be predicted that these cases can benefit from trastuzumab treatment.