http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Cheong, Hyun Sub,Yoon, Du-Hak,Kim, Lyoung Hyo,Park, Byung Lae,Lee, Hye Won,Namgoong, Sohg,Kim, Eun Mi,Chung, Eui Ryong,Cheong, Il-Cheong,Shin, Hyoung Doo Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.3
The insulin-like growth factor binding protein 3 (IGFBP3) has been investigated as a candidate gene for growth promoting effects in beef cattle and a modulator of IGF bioactivity. Previously, we have reported twenty two sequence variants discovered in Korean native cattle (Hanwoo). In this study, we examined the association between gene-specific polymorphisms of IGFBP3 and cold carcass weight (CW) and marbling score (MS) among Korean native cattle. Among twenty two polymorphisms, four common polymorphic sites (-854G>C, -100G>A, +421G>T and +3863C>A) were genotyped in our beef cattle (n = 437). Statistical analysis revealed that one common polymorphism in the promoter region (-854G>C) showed putative associations with MS (p = 0.03). IGFBP3 variation/haplotype information analyzed in this study will provide valuable information into strategies for the production of a commercial line of beef cattle.
Leptin Polymorphisms Associated with Carcass Traits of Meat in Korean Cattle
Cheong, Hyun Sub,Yoon, Du-Hak,Kim, Lyoung Hyo,Park, Byung Lae,Chung, Eui Ryong,Lee, Han Ju,Cheong, Il-Cheong,Oh, Sung-Jong,Shin, Hyoung Doo Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.11
Leptin has been investigated as a candidate gene for fat characteristics in beef cattle. Previously, we have reported 57 sequence variants discovered in Korean cattle (Bos Taurus coreanae). In this study, we examined the association between polymorphisms of leptin and carcass traits (cold carcass weight (CWT) and marbling score (Marb)) in Korean cattle. Among 57 polymorphisms, 11 common polymorphic sites were genotyped in our beef cattle (n = 437). Statistical analysis revealed that one single nucleotide polymorphism in coding exon (c.+411T>C (A137A)) showed a significant association with the yield trait, CWT. The C-bearing genotypes (CC or CT) of c.+411T>C (A137A) showed the higher CWT (p = 0.006). c.+150C>G (S50S) also showed a significant association with the quality trait, Marb (p = 0.01). Our findings suggest that polymorphisms in leptin might be one of the important genetic factors that influence carcass yield and quality in beef cattle, especially in CWT and Marb.
RNA-Seq for Gene Expression Profiling of Human Necrotizing Enterocolitis: a Pilot Study
Jung, Kyuwhan,Koh, InSong,Kim, Jeong-Hyun,Cheong, Hyun Sub,Park, Taejin,Nam, So Hyun,Jung, Soo-Min,Sio, Cherry Ann,Kim, Su Yeong,Jung, Euiseok,Lee, Byoungkook,Kim, Hye-Rim,Shin, Eun,Jung, Sung-Eun,Cho The Korean Academy of Medical Sciences 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.5
<P>Necrotizing enterocolitis (NEC) characterized by inflammatory intestinal necrosis is a major cause of mortality and morbidity in newborns. Deep RNA sequencing (RNA-Seq) has recently emerged as a powerful technology enabling better quantification of gene expression than microarrays with a lower background signal. A total of 10 transcriptomes from 5 pairs of NEC lesions and adjacent normal tissues obtained from preterm infants with NEC were analyzed. As a result, a total of 65 genes (57 down-regulated and 8 up-regulated) revealed significantly different expression levels in the NEC lesion compared to the adjacent normal region, based on a significance at fold change ≥ 1.5 and <I>P</I> ≤ 0.05. The most significant gene, <I>DPF3</I> (<I>P</I> < 0.001), has recently been reported to have differential expressions in colon segments. Our gene ontology analysis between NEC lesion and adjacent normal tissues showed that down-regulated genes were included in nervous system development with the most significance (<I>P</I> = 9.3 × 10<SUP>−7</SUP>; <I>P<SUB>corr</SUB></I> = 0.0003). In further pathway analysis using Pathway Express based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) database, genes involved in thyroid cancer and axon guidance were predicted to be associated with different expression (<I>P<SUB>corr</SUB></I> = 0.008 and 0.020, respectively). Although further replications using a larger sample size and functional evaluations are needed, our results suggest that altered gene expression and the genes' involved functional pathways and categories may provide insight into NEC development and aid in future research.</P>
Association of <i>RANBP1</i> haplotype with smooth pursuit eye movement abnormality
Cheong, Hyun Sub,Park, Byung Lae,Kim, Eun Mi,Park, Chul Soo,Sohn, Jin‐,Wook,Kim, Bong‐,Jo,Kim, Jae Won,Kim, Ki‐,Hoon,Shin, Tae‐,Min,Choi, Ihn‐,Geun,Han, Sang‐,Woo,H Wiley Subscription Services, Inc., A Wiley Company 2011 American Journal of Medical Genetics Part B: Neuro Vol. No.
<P><B>Abstract</B></P><P>Schizophrenia is a multifactorial disorder and smooth pursuit eye movement (SPEM) disturbance is proposed as one of the most consistent neurophysiological endophenotype in schizophrenia. The aim of this study was to examine the genetic association of <I>RANBP1</I> polymorphisms with the risk of schizophrenia and with the risk of SPEM abnormality in schizophrenia patients in a Korean population. Two SNPs of <I>RANBP1</I> were genotyped by TaqMan assay. Their genetic effect of single/haplotype polymorphisms on the risk of schizophrenia and SPEM abnormality from 354 patients and 396 controls were performed using <I>χ</I><SUP>2</SUP> and multiple regression analyses. Although no <I>RANBP1</I> polymorphisms were associated with the risk of schizophrenia, a common haplotype, <I>RANBP1‐ht2</I> (<I>rs2238798G–rs175162T</I>), showed significant association with the risk of SPEM abnormality among schizophrenia patients after multiple correction (<I>P</I><SUP>corr</SUP> = 0.002–0.0003). The results of present study provide the evidence that <I>RANBP1</I> on 22q11.21 locus might be causally related to the SPEM abnormality rather than the development of schizophrenia. © 2010 Wiley‐Liss, Inc.</P>
NT5C3 polymorphisms and outcome of first induction chemotherapy in acute myeloid leukemia
Cheong, Hyun Sub,Koh, Youngil,Ahn, Kwang-Sung,Lee, Chansu,Shin, Hyoung Doo,Yoon, Sung-Soo Wolters Kluwer Health | Lippincott Williams Wilkin 2014 PHARMACOGENETICS AND GENOMICS Vol.24 No.9
AIMS: The cytosolic 5&vprime;-nucleotidase-III (NT5C3) is involved in the metabolism of the nucleoside analog, cytosine arabinose (AraC), and the expression level of NT5C3 is correlated with sensitivity to AraC in acute myeloid leukemia (AML) patients. The current study examined whether the NT5C3 polymorphisms could affect chemotherapy outcomes in 103 Korean AML patients. METHODS: Forty-seven single nucleotide polymorphisms in NT5C3 were genotyped using the Illumina GoldenGate genotyping assay. The genetic effects of the polymorphisms on the outcome of chemotherapy were analyzed using &khgr; and logistic regression models. RESULTS: Although none of the NT5C3 polymorphisms was associated with a complete remission rate, a common single nucleotide polymorphism, rs3750117, showed a significant association with induction rate after the first course of chemotherapy (Pcorr=0.004 and odds ratio=11.28) in AML patients. In addition, NT5C3 expression levels were significantly increased in patients with risk allele homozygote. CONCLUSIONS: The data suggest that genotyping the NT5C3 polymorphism may have the potential to identify patients more likely to respond to AraC-based chemotherapy.
Screening of genetic variations of SLC15A2, SLC22A1, SLC22A2 and SLC22A6 genes.
Cheong, Hyun Sub,Kim, Hae Deun,Na, Han Sung,Kim, Ji On,Kim, Lyoung Hyo,Kim, Seung Hee,Bae, Joon Seol,Chung, Myeon Woo,Shin, Hyoung Doo Springer-Verlag 2011 Journal of human genetics Vol.56 No.9
<P>A growing list of membrane-spanning proteins involved in the transport of a large variety of drugs has been recognized and characterized to include peptide and organic anion/cation transporters. Given such an important role of transporter genes in drug disposition process, the role of single-nucleotide polymorphisms (SNPs) in such transporters as potential determinants of interindividual variability in drug disposition and pharmacological response has been investigated. To define the distribution of transporter gene SNPs across ethnic groups, we screened 450 DNAs in cohorts of 250 Korean, 50 Han Chinese, 50 Japanese, 50 African-American and 50 European-American ancestries for 64 SNPs in four transporter genes encoding proteins of the solute carrier family (SLC15A2, SLC22A1, SLC22A2 and SLC22A6). Of the 64 SNPs, 19 were core pharmacogenetic variants and 45 were HapMap tagging SNPs. Polymorphisms were genotyped using the golden gate genotyping assay. After genetic variability, haplotype structures and ethnic diversity were analyzed, we observed that the distributions of SNPs in a Korean population were similar to other Asian groups (Chinese and Japanese), and significantly different from African-American and European-American cohorts. Findings from this study would be valuable for further researches, including pharmacogenetic studies for drug responses.</P>
Association of Interleukin-18 Gene Polymorphisms with Hepatitis B Virus Clearance
Cheong, Jae Youn,Cho, Sung Won,Oh, Bermseok,Kimm, Kuchan,Lee, Kee Myung,Shin, Sung Jae,Lee, Jung A.,Park, Byung Lae,Cheong, Hyun Sub,Shin, Hyoung Doo,Cho, Bo Young,Kim, Jin Hong Springer-Verlag 2010 Digestive diseases and sciences Vol.55 No.4
A Study in Regards to Service Quality and Customer Satisfaction of Franchised Coffee Shops
Cheong Sub Shin,Gyu Sam Hwang,Hye Won Lee 한국유통과학회 2015 KODISA ICBE (International Conference on Business Vol.2015 No.-
This study deducts service quality factors based on a pilot research. We analyzed deduced service quality factors and store atmosphere as additional service quality factors. The effects of service quality of store atmosphere on customer satisfaction and customer loyalty will be determined. Additionally, the impact of customer satisfaction, which is influenced by service quality factors and store atmosphere, on customer loyalty will be decided. Based on analysis result above, we will provide customer oriented service quality strategy implication to franchised coffee shops. According to the analysis of hypothesis 1, taste is revealed to be the most influential factor among components which have impacts on service quality. Trust and reactivity, assurance and empathy, and corporeality and store atmosphere have influence on service quality respectively. According to the analysis of hypothesis 2, taste turned on to have the most impact on service quality among components influencing service quality. In sequence, assurance and empathy, trust and reactivity, and corporeality and store atmosphere have influence on service quality respectively. Based on the analysis of hypothesis 3, customer satisfaction tuned out to affect customer loyalty.
Epigenetic modification of retinoic acid-treated human embryonic stem cells
( Hyun Sub Cheong ),( Han Chul Lee ),( Byung Lae Park ),( Hye Min Kim ),( Mi Jin Jang ),( Yong Mahn Han ),( Seun Young Kim ),( Yong Sung Kim ),( Hyoung Doo Shin ) 생화학분자생물학회 (구 한국생화학분자생물학회) 2010 BMB Reports Vol.43 No.12
Epigenetic modification of the genome through DNA methylation is the key to maintaining the differentiated state of human embryonic stem cells (hESCs), and it must be reset during differentiation by retinoic acid (RA) treatment. A genome-wide methylation/gene expression assay was performed in order to identify epigenetic modifications of RA-treated hESCs. Between undifferentiated and RA-treated hESCs, 166 differentially methylated CpG sites and 2,013 differentially expressed genes were discovered. Combined analysis of methylation and expression data revealed that 19 genes (STAP2, VAMP8, C10orf26, WFIKKN1, ELF3, C1QTNF6, C10orf10, MRGPRF, ARSE, LSAMP, CENTD3, LDB2, POU5F1, GSPT2, THY1, ZNF574, MSX1, SCMH1, and RARB) were highly correlated with each other. The results provided in this study will facilitate future investigations into the interplay between DNA methylation and gene expression through further functional and biological studies. [BMB reports 2010; 43(12): 830-835]