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Fink, Stephen P,Yang, Dong-Hoon,Barnholtz-Sloan, Jill S,Ryu, Yeon-Mi,Mikkola, Debra,Potter, John D,Lampe, Johanna W,Markowitz, Sanford D,Myung, Seung-Jae Plenum Pub. Corp.] 2013 Digestive diseases and sciences Vol.58 No.9
<P>15-Hydroxprostaglandin dehydrogenase (15-PGDH) mediates a colon neoplasia suppressor pathway, acting through metabolic antagonism of cyclooxygenase-mediated colon carcinogenesis. To determine whether the colon tumor prevention activity of 15-PGDH acts as a constant or variable effect among individuals, we determined whether 15-PGDH levels remain stable over subsite and time in the human colon, determined the extent of differences in 15-PGDH levels between different individuals, and determined whether 15-PGDH modulation mediates any part of the anti-colon tumor effect of aspirin.</P>