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만성 골수성 백혈병 환자에서 발생한 거대 후복막강내 혈종 1예
박기령,김영선,박사영,최진혁,이순남,정화순 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.1
Thrombohemorrhagic complications in chronic myeloproliferative disease(CMPD) including chronic myelogenous leukemia(CML) are not rare. Lower incidence of disordered hemostasis is reported in CML compared with other CMPD. The mechanism of thrombohemorrhagic complications might be a consequence of qualitative platelet abnormalites and prolonged bleeding time rather than that of thrombocytosis. Although defect of platelet function has been extensively investigated, there was no established consistent correlation between clinical bleeding and number and function of platelet. The most common site of bleeding complications in the CMPD is superficial mucosa. Bleeding in deep tissue and viscera is very unusual. We report a case of CML which developed a huge spontaneous retroperitoneal hematoma.
대장암 환자의 임상양상에 따른 EGFR Mutation의 발생 빈도
오보영,이령아,정순섭,김광호 이화여자대학교 의과학연구소 2013 EMJ (Ewha medical journal) Vol.36 No.1
Objectives: The EGFR plays an important role in tumorigenesis and tumor progression of colorectal cancer, and leads to the activation of intracellular signaling pathways. The use of anti-EGFR-targeted therapy has increased for patients with colorectal cancer, but patients with EGFR mutations will be resistant to anti-EGFR-targeted therapy. The identification of gene mutations is critical in cancer treatment; therefore, the aim of this study is to investigate the incidences of EGFR mutations in colorectal cancer patients in Korea. Methods: We reviewed 58 colorectal cancer patients who underwent operations between 2003 and 2006, retrospectively. We analyzed their EGFR mutations in 4 loci by DNA sequencing. In addition, we analyzed the correlation between the presence of EGFR mutation and patients’ clinicopathologic features. Results: Of the 58 patients, 35 patients were male and 23 were female. Their mean age was 63.28±11.18 years. Two patients (3.45%) were diagnosed as stage Tis, 7 patients (12.07%) had stage I, 24 patients (41.38%) had stage II, 20 patients (34.48%) had stage III, and 5 patients (8.62%) had stage IV. As a result of mutational analysis, EGFR mutations on exon 20 were detected in 13 patients (22.41%, G→A transitions). EGFR mutations on exon 18, 19 and 21 were not detected. EGFR mutation increased in the earlier stage and the absence of lymph node metastasis (P=0.028). Conclusion: The incidence of EGFR mutation in Korean colorectal cancer patients is 22.41%. In addition, EGFR mutation significantly increased in the earlier stage and the absence of lymph node metastasis.
김윤영,김남령,이용균,최순규,이시우,정대일 東亞大學校 1993 東亞論叢 Vol.30 No.1
As a new protective group for diols, cyclic oxalates (20) (24) were synthesized by using oxalyl chloride, ethyl oxalyl chloride, diethyl oxalate and oxalic acid. In the reaction of diol with oxalyl chloride, the product was a mixture of the cyclic oxalate (20) and mono oxalated(21). When ethyl oxalyl chloride was used which pyridine as base, acyclic oxalates (22) (25) were obtained. Whereas ethyl oxalyl chloride which triethylamine instead of pyridine, cyclic oxalates (20) (24) as well as acyclic oxalates (22) (25) were obtained. Using diethyl oxalate, the amounts of cyclic oxalates (20) (24) were increased, but there were some difficulties in separations of its desired products. Oxalic acid, however, did not afford cyclic oxalates but gave formate which probably was formed by decarboxylation of hydroxyoxalyl group.
대장암에서 개복 대장절제술, 복강경 대장절제술 및 수부 보조 복강경 대장절제술의 단기 추적 관찰 결과의 비교
홍경숙,노경태,오보영,이령아,정순섭,김광호 이화여자대학교 의과학연구소 2011 EMJ (Ewha medical journal) Vol.34 No.2
Objectives: Hand-assisted laparoscopic surgery had both technical advantages of open surgery and better postoperative short-term follow-up results of laparoscopic surgery. We compared open colectomy, laparoscopic colectomy and hand-assisted laparoscopic colectomy, and tried to find the most effective operative modality. Methods: 90 patients, who were diagnosed with colorectal cancer and underwent colectomy in our institution, were categorized as 3 groups of open colectomy (OC) group, laparoscopic colectomy (LC) group and hand-assisted laparoscopic colectomy (HALC) group by the surgical modality. Results: In this study, ratio of male and female was 57:37, and mean age was 64.1 years old. LC group and HALC group showed longer operation time, shorter hospital stay after operation, lesser pain and earlier removal of closed drainage catheter than OC group. Amount of bleeding during operation, frequency of transfusion and incidence of complication showed no significant difference. In permanent pathologic results, the number of harvested lymph nodes had significant difference between OC group and other groups (P=0.030), but it was probably caused by the bias of the different distribution of the stages in each group. Overall 14 of the cases resulted in complications while there was no mortality. Conclusion: Laparoscopic colectomy and hand-assisted laparoscopic colectomy showed better short-term follow-up results rather than open colectomy. And hand-assisted laparoscopic surgery could provide tactile sensation to operator, which lacked in laparoscopic surgery. Hand-assisted laparoscopic colectomy could be an alternative surgical option for colorectal cancer with these advantages.
Design and Control Method of ZVT Interleaved Bidirectional LDC for Mild-Hybrid Electric Vehicle
Soon-Ryung Lee,Jong-Young Lee,Won-Sang Jung,Il-Kwon Won,Joung-Hwan Bae,Chung-Yuen Won 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.1
In this paper, design and control method ZVT Interleaved Bidirectional LDC(IB-LDC) for mild-hybrid electric vehicle is proposed. The IB-LDC is composed of interleaved buck and boost converters employing an auxiliary inductor and auxiliary capacitors to achieve zero-voltage-transition. Operating principle of IB-LDC according to operation mode is introduced and mathematically analyzed in buck and boost mode. Moreover, PFM and phase control are proposed to reduce circulating current for low power range. Passive components design such as main inductor, auxiliary inductor and capacitors is suggested, considering ZVT condition and maximizing efficiency. Furthermore, a 600W prototype of ZVT IB-LDC for MHEVs is built and tested to verify validity.
Design and Control Method of ZVT Interleaved Bidirectional LDC for Mild-Hybrid Electric Vehicle
Lee, Soon-Ryung,Lee, Jong-Young,Jung, Won-Sang,Won, Il-Kwon,Bae, Joung-Hwan,Won, Chung-Yuen The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.1
In this paper, design and control method ZVT Interleaved Bidirectional LDC(IB-LDC) for mild-hybrid electric vehicle is proposed. The IB-LDC is composed of interleaved buck and boost converters employing an auxiliary inductor and auxiliary capacitors to achieve zero-voltage-transition. Operating principle of IB-LDC according to operation mode is introduced and mathematically analyzed in buck and boost mode. Moreover, PFM and phase control are proposed to reduce circulating current for low power range. Passive components design such as main inductor, auxiliary inductor and capacitors is suggested, considering ZVT condition and maximizing efficiency. Furthermore, a 600W prototype of ZVT IB-LDC for MHEVs is built and tested to verify validity.
Lee, Jae Ryung,Kim, Jae Seung,Roh, Jong-Lyel,Lee, Jeong Hyun,Baek, Jung Hwan,Cho, Kyung-Ja,Choi, Seung-Ho,Nam, Soon Yuhl,Kim, Sang Yoon Radiological Society of North America 2015 Radiology Vol.274 No.3
<P>Purpose: To assess diagnostic accuracy of fluorine 18 (F-18) fluorodeoxyglucose (FDG) combined positron emission tomography (PET) and computed tomography (CT) in the detection of occult primary tumors and determination of optimal care in patients with cervical metastasis of an unknown primary tumor (CUP) compared with contrast material-enhanced CT alone or combined contrast-enhanced CT and magnetic resonance (MR) imaging (CT/MR imaging). Materials and Methods: Institutional review board approval and written informed consent were obtained. In total, 56 patients with initially undetected tumors after endoscopic or physical examination were prospectively assessed with F-18 FDG PET/CT and contrast-enhanced CT or contrast-enhanced CT/MR imaging. The contrast-enhanced CT/MR images were read in combination. Results of guided biopsy with general anesthesia served as the reference standard. Diagnostic values of F-18 FDG PET/CT, contrast-enhanced CT, and contrast-enhanced CT/MR imaging were compared with the McNemar test. Results: Primary tumors were detected at 32 sites in 31 (55%) of 56 patients. There were 26 tumors in the palatine tonsil, two in the hypopharynx, two in the base of the tongue, and two in the nasopharynx. PET/CT depicted 22 (69%) of 32 primary tumors, but it failed to depict primary tumors in 10 (31%) of 32 cases. Overall, sensitivity of PET/CT (69%) in detection of primary tumors was higher than that of contrast-enhanced CT (16%) (P < .001) or contrast-enhanced CT/MR imaging (41%) (P = .039), while specificity of these methods did not differ (88%, 76%, and 59% for PET/CT, contrast-enhanced CT, and contrast-enhanced CT/MR imaging, respectively; P > .4). Diagnostic performance (area under the receiver operating characteristics curve [AUC] = 0.759) of PET/CT in tumor detection was significantly better than that of contrast-enhanced CT alone (AUC = 0.531) (P = .001) or contrast-enhanced CT/MR imaging (AUC = 0.537) (P = .036). PET/CT depicted primary tumors in eight (50%) of 16 cases of false-negative CT/MR imaging findings, one distant metastatic case, and two cases of synchronous cancer. Conclusion: F-18 FDG PET/CT is more sensitive in detection of primary tumors than is contrast-enhanced CT or contrast-enhanced CT/MR imaging in patients with CUP; therefore, it may lead to improved therapeutic planning in these patients. (C) RSNA, 2014</P>
Lee, Seok Jeong,Lee, Jong-Young,Jung, Soon Hee,Lee, Shun Nyung,Lee, Ji-Ho,Kim, Chong Whan,Jung, Saehyun,Jung, Ye-Ryung,Lee, Won-Yeon The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.73 No.6
High-dose-rate endobronchial brachytherapy (HDREB) have been used as the treatment of early endobronchial cancer, as well as for palliation of advanced cancer. However, fatal hemoptysis can occur after HDREB at the rate of 7~32%. We report a case of massive hemoptysis due to radiation bronchitis developed after HDREB. A 67-year-old man was treated with HDREB for early endobronchial cancer on the left upper lobe bronchus. He complained of persistent cough from 4 weeks after completion of HDREB. Radiation bronchitis was observed on the bronchoscopy at 34 weeks, and it was progressed from mucosal swelling and exudate formation to necrosis and ulceration without local relapse. In addition, he died of massive hemoptysis after 15 months. The patient had no sign or radiologic evidences to predict the hemoptysis. This case implies that HDREB directly contributes to an occurrence of a fatal hemoptysis, and follow-up bronchoscopy is important to predict a progression of radiation bronchitis and fatal hemoptysis.