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Sox12 Is a Cancer Stem-Like Cell Marker in Hepatocellular Carcinoma
Song Zou,Chen Wang,Jiansheng Liu,Qun Wang,Dongdong Zhang,Shengnan Zhu,Shengyuan Xu,Mafei Kang,Shaozhong He 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.11
Recent studies on molecular carcinogenesis suggest that the chemo-resistance of some cancers is largely due to presence of cancer stem cells (CSCs), which affect the chemotherapy outcome for hepatocellular carcinoma (HCC). However, currently no consensus on a CSC phenotype in HCC has been obtained. Here, we examined Sox12 as a novel CSC marker in HCC. Sox12+ versus Sox12- cells were purified from HCC cell lines. The Sox12+ cells were compared with Sox12- HCC cells for tumor sphere formation, chemo-resistance, tumor formation after serial adoptive transplantations in nude mice, and the frequency of developing distal metastasis. We found that compared to Sox12- HCC cells, Sox12+ HCC cells generated significantly more tumor spheres in culture, were more chemo-resistant to cisplatin, were detected in circulation more frequently, and formed distal tumor more frequently. Moreover, Sox12 ap-peared to functionally contribute to the stemness of HCC cells. Thus, we conclude that Sox12 may be a novel marker for enriching CSCs in HCC.
Static and Cyclic Tension Behavior of Post-Installed Rebar after Exposure to High Temperature
Qun Xie,Song Xue,Yongqiang Zhao 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.6
In order to investigate the static and cyclic tension behavior of post-installed rebar along with cement-based adhesive that is adopted after exposure to high temperature, a three-phase experimental program has been carried out and two typical embedment depths, 10d and 15dare designed. The surfaces of specimens are firstly heated up to 800oC, and then the residual strength at different temperatures of cement-based adhesive has been studied by consequent static pull-out tests. Experimental results show that the tensile strength has a significant reduction at elevated temperatures compared with that of room temperature. The cement-based adhesive has almost lost its full bond strength when the temperature exceeds 350oC. Finally, the bond performance of cement-based adhesive under cyclic loading has been further tested and analyzed. It is found that both 10d and 15d specimens have failed abruptly with rebar pull-out. The employment of long embedment depth has been verified to be an effective method to improve the bond performance of cement-based adhesive under static and cyclic loading. Static numerical investigation indicates that the bond stress distribution is not uniform along the embedment length of post-installed rebar at different temperatures of cement-based adhesive. The temperature-dependent tensile strength prediction has also been obtained based on the experimental data.
Qun Huang,Shu-gang Li,Hui Teng,Yong-guo Jin,Mei-hu Ma,Hong-bo Song 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.6
Angiotensin-I-converting enzyme (ACE) inhibitory peptides were prepared from ovalbumin using enzyme hydrolysis with pepsin as an enzyme source. Effects of pH, enzyme dosage, substrate concentration, hydrolysis temperature, and time on the degree of hydrolysis and the ACE inhibition rate were investigated using single factor experiments. Preparation conditions for ACE inhibitory peptides were optimized using a response surface design on the base of single factor experiments. Optimum preparation conditions were a substrate concentration of 5.2 g/100 mL of D.W with a pH value of 2.5, an enzyme dosage of 14,000 U/g, and a hydrolysis time of 250 min at 30℃. The ACE inhibition rate was up to 70.55±1.13% under these conditions.
Guan-Qun Wu,Shen-Min Song,Jing-Guang Sun 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.3
This thesis studies the spacecraft terminal safe approach control problem considering input saturation. Based on the spacecraft relative motion model and sphere collision avoidance potential function, an anti-saturation controller and an adaptive finite-time anti-saturation controller using dynamic surface control(DSC) are presented for the situations of known and unknown upper bound of external disturbances respectively, which can guarantee that no collisions happen in the tracking process. The second-order tracking differentiator is introduced to design the controllers, which avoids the differential of the virtual control signal and ensures the tracking performance of system output signals. Meanwhile, the auxiliary system is introduced to handle input saturation. Lyapunov stability theory is adopted to prove that the states of system under the designed controllers are uniformly ultimately bounded and practical finite-time stable respectively, and the chaser spacecraft can approach to the desired position without collision. The numerical simulation results demonstrate that the chaser spacecraft using the designed controllers can realize terminal safe approach to target spacecraft, which further illustrate the effectiveness of the proposed controllers.
Fan, Qun,Choi, Changhyeok,Yan, Chao,Liu, Yongchao,Qiu, Jieshan,Hong, Song,Jung, Yousung,Sun, Zhenyu The Royal Society of Chemistry 2019 Chemical communications Vol.55 No.29
<P>We report ambient electrochemical N2 fixation at low overpotentials by using two-dimensional (2D) β-boron. The metal-free catalyst afforded both an excellent NH3 yield rate and faradaic efficiency, approximately two times higher than those of bulk boron. We found that several binding sites, especially those involving icosahedral boron in the 2D material, can indeed catalyze N2 reduction efficiently with strong N2 adsorption, thus benefiting initial activation.</P>
Zhang, Qun-Cheng,Jiang, Shu-Juan,Zhang, Song,Ma, Xiao-Bin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
Background and Objective: Histone deacetylase (HDAC) inhibitors represent a promising class of potential anticancer agents for treatment of human malignancies. In this study, we investigated the effect of trichostatin A (TSA), one such HDAC inhibitor, in combination with docetaxel (TXT), a cytotoxic chemotherapy agent or erlotinib, a novel molecular target therapy drug, on lung cancer A549 cells. Methods: A549 cells were treated with TXT, erlotinib alone or in combination with TSA, respectively. Cell viability, apoptosis, and cell cycle distribution were evaluated using MTT (3- (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium bromide) assay, Hochst33258 staining and flow cytometry. Moreover, immunofluorescent staining and Western blot analysis were employed to examine alterations of ${\alpha}$-tubulin, heat shock protein 90 (hsp90), epidermal growth factor receptor (EGFR), and caspase-3 in response to the different exogenous stimuli. Results: Compared with single-agent treatment, co-treatment of A549 cells with TSA/TXT or TSA/erlotinib synergistically inhibited cell proliferation, induced apoptosis, and caused cell cycle delay at the $G_2/M$ transition. Treatment with TSA/TXT or TSA/erlotinib led to a significant increase of cleaved caspase-3 expression, also resulting in elevated acetylation of ${\alpha}$-tubulin or hsp90 and decreased expression of EGFR, which was negatively associated with the level of acetylated hsp90. Conclusions: Synergistic anti-tumor effects are observed between TXT or erlotinib and TSA on lung cancer cells. Such combinations may provide a more effective strategy for treating human lung cancer.
Multi-objective Optimization for Time-Open Lambert Rendezvous Between Non-coplanar Orbits
Guan-Qun Wu,Li-Guo Tan,Xin Li,Shen-Min Song 한국항공우주학회 2020 International Journal of Aeronautical and Space Sc Vol.21 No.2
The problem of time-open Lambert multi-objective optimal rendezvous between non-coplanar orbits is studied in the paper. Based on the Lambert’s theorem, the descriptions of time-open Lambert rendezvous subjected to two-impulse and three-impulse are presented, and a universally applicable method for the solution of the transfer orbits is given. To deal with the multi-objective optimization subject to fuel consumption and flight time for rendezvous, an improved NSGA-II algorithm with a better performance is provided. Via the global optimization, Pareto set can be obtained by the improved NSGA-II for the multi-objective optimal rendezvous considering multi-constraints. Numerical simulations are conducted to validate the feasibility of the improved multi-objective optimization algorithm, and the results of the two-impulse and three-impulse multi-objective optimal rendezvous are shown.
Lee, Song Joo,Ren, Yupeng,Press, Joel M.,Lee, Jungwha,Zhang, Li-Qun IEEE 2017 IEEE transactions on neural systems and rehabilita Vol.25 No.11
<P>Knee injuries are usually associated with offaxis loadings in the transverse and frontal planes. Thus, improvement of lower limb offaxis neuromuscular control is important in knee injury prevention and post-injury rehabilitation. The goal of this paper was to investigate the effects of six-week pivoting offaxis intensity adjustable neuromuscular control training (POINT) using a custom-made offaxis elliptical trainer on lower limb offaxis neuromuscular control performance in trained and untrained functional tasks under slippery conditions. Twenty-six subjects participated in 18 sessions of POINT (three sessions per week for six weeks) and 25 subjects served as controls who did a regular workout. Offaxis neuromuscular control performance measures in terms of pivoting instability, sliding instability, and time-to-peak offaxis EMG entropy were evaluated on both groups under slippery conditions including a trained free pivoting task and untrained free sliding task and free pivoting and sliding task. Compared with the control group, the training group significantly decreased pivoting instability and the time-to-peak offaxis EMG entropy in lower limb muscles, indicating improvement in offaxis neuromuscular control performance. Furthermore, the training group showed reduced pivoting instability and sliding instability during the untrained free pivoting and sliding task. This paper may help us develop more focused and effective offaxis training programs to reduce knee injuries associated with offaxis loadings.</P>