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Xin Caiyan,Wang Fen,Zhang Jinping,Zhou Quan,Liu Fangyan,Zhao Chunling,Song Zhangyong 한국미생물학회 2023 The journal of microbiology Vol.61 No.2
Candida spp. and Cryptococcus are conditional pathogenic fungi that commonly infect immunocompromised patients. Over the past few decades, the increase in antifungal resistance has prompted the development of new antifungal agents. In this study, we explored the potential antifungal effects of secretions from Serratia marcescens on Candida spp. and Cryptococcus neoformans. We confirmed that the supernatant of S. marcescens inhibited fungal growth, suppressed hyphal and biofilm formation, and downregulated the expression of hyphae-specific genes and virulence-related genes in Candida spp. and C. neoformans. Furthermore, the S. marcescens supernatant retained biological stability after heat, pH, and protease K treatment. The chemical profile of the S. marcescens supernatant was characterized by ultra-high-performance liquid chromatography–linear ion trap/orbitrap high resolution mass spectrometry analysis and a total of 61 compounds with an mzCloud best match of greater than 70 were identified. In vivo, treatment with the S. marcescens supernatant reduced the mortality of fungi-infected Galleria mellonella. Taken together, our results revealed that the stable antifungal substances in the supernatant of S. marcescens have promising potential applications in the development of new antifungal agents.
Zhang, Yong ,Jian,Kim, Kee ,Yong,Park, Jung ,Hwan,Song, Choong ,Eui,Lee, Kyungae,Lah, Myoung ,Soo,Lee, Sang-gi WILEY-VCH Verlag 2005 Advanced synthesis & catalysis Vol.347 No.4
<P>The diastereomeric 1,4-diphosphine ligands, (S,S,S,S)-1a, (R,S,S,R)-1b and (R,S,S,S)-1c, with the imidazolidin-2-one backbone were synthesized, and utilized for an investigation of the effects of backbone chirality on the enantioselectivity in the Rh(I)-catalyzed hydrogenation of various functionalized olefinic substrates. It was found that the catalytic efficiencies are largely dependent on the configurations of the α-carbons to phosphine. Thus, the Rh complex of the pseudo-C<SUB>2</SUB>-symmetrical diphosphine, (R,S,S,S)-1c, showed excellent enantioselectivities (93.0–98.6% ees) in the hydrogenations of a broad spectrum of substrates, and especially in the hydrogenations of methyl α-(N-acetyamino)-β-arylacrylates (95.3–97.0% ees). However, the enantioselectivities obtained with the C<SUB>2</SUB>-symmetrical (R,S,S,R)-1b were largely dependent on the substrate (19.8–97.3% ees). The Rh complex of ligand 1a having the (S,S,S,S)-configuration showed the lowest catalytic efficiency for all of the substrates examined (0–84.8% ees).</P>