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( Song Hee Han ),( Hye In Cheon ),( Min Seok Hur ),( Byung Gon Choi ),( Min Jung Kim ),( Hae Jeong Youn ),( Soo Young Kim ),( Nam Kyung Roh ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: The genus Malassezia is associated with a wide range of skin diseases and is the predominant fungal genus isolated from human skin. Of the 14 Malassezia species identified, M. restricta is the most abundant fungal species found from both healthy and diseased skin. Objectives: This study aimed to characterise the lipase 1 homologue (MrLip1) in M. restricta and to analyse its expression under different environmental conditions. Methods: The full sequence of the gene encoding MrLip1 was determined by rapid amplification of cDNA ends, and it was then heterologously expressed in Pichia pastoris. Results: MrLip1 protein was successfully purified and used for lipase assay and specific antibody generation for use in expression analysis. The optimum pH and temperature for the activity of purified MrLip1 were pH 5.0 and 34 °C respectively. Conclusion: We have identified, characterised and analysed MrLIP1, which encodes the lipase 1 homologue of M. restricta. We successfully purified MrLip1 protein using the P. pastoris expression system, and we used the purified protein to determine the optimal conditions for the enzymatic activity and expression of MrLip1. The optimal pH and temperature for MrLip1 activity and expression were similar to the conditions typically found on the host skin surface, implying that the protein plays a critical role in the survival of the fungus in the host niche.
Case Reports : Four Cases of Non-Hodgkin`s Lymphoma in AIDS patients
Kyung Mi Kang,Do Seon Song,Jin Min Park,Chan Kwon Jung,Young Seon Hong,Moon Won Kang,Chong Won Park 대한내과학회 2006 The Korean Journal of Internal Medicine Vol.21 No.4
The incidence of opportunistic infection has decreased since the introduction of highly active antiretroviral therapy, so lymphoma is now far and away the most lethal complication of acquired immunodeficiency syndrome. We have experienced four cases of NHL in AIDS patients. The first patient was a 37 year old male who presented with left sided hemiplegia due to CNS lymphoma. The second patient was a 40 year old male who was admitted because of jaundice; he was diagnosed as having lymphoma that exclusively involved the liver. The third patient was a 38-year-old male who presented with palpable mass in the left cervical region, which was diagnosed as lymphoma. Above three cases were confirmed as diffuse large B cell lymphoma. The fourth patient presented with a protruding swollen chest wall mass on the right side of his chest, this was determined pathologically to be the Burkitt`s type. The latter case is the first report of NHL involving the chest wall musculature in a Korean AIDS patient.
Won, Jong-Ryul,Song, Kyung-Bin The Korean Institute of Electrical Engineers 2013 Journal of Electrical Engineering & Technology Vol.8 No.6
This study performed an analysis on power demand reduction effects exhibited by demand response programs, which are advanced from traditional demand-side management programs, in the smart grid environment. The target demand response systems for the analysis included incentive-based load control systems (2 month-ahead demand control system, 1~5 days ahead demand control system, and demand bidding system), which are currently implemented in Korea, and price-based demand response systems (mainly critical peak pricing system or real-time pricing system, currently not implemented, but representative demand response systems). Firstly, the status of the above systems at home and abroad was briefly examined. Next, energy saving effects and peak demand reduction effects of implementing the critical peak or real-time pricing systems, which are price-based demand response systems, and the existing incentive-based load control systems were estimated.
DJ-1 deficiency impairs synaptic vesicle endocytosis and reavailability at nerve terminals
Kyung, Jae Won,Kim, Jin-Mo,Lee, Wongyoung,Ha, Tae-Young,Cha, Seon-Heui,Chung, Kyung-Hwun,Choi, Dong-Joo,Jou, Ilo,Song, Woo Keun,Joe, Eun-Hye,Kim, Sung Hyun,Park, Sang Myun National Academy of Sciences 2018 Proceedings of the National Academy of Sciences Vol.115 No.7
<P>Mutations in DJ-1 (PARK7) are a known cause of early-onset autosomal recessive Parkinson's disease (PD). Accumulating evidence indicates that abnormalities of synaptic vesicle trafficking underlie the pathophysiological mechanism of PD. In the present study, we explored whether DJ-1 is involved in CNS synaptic function. DJ-1 deficiency impaired synaptic vesicle endocytosis and reavailability without inducing structural alterations in synapses. Familial mutants of DJ-1 (M26I, E64D, and L166P) were unable to rescue defective endocytosis of synaptic vesicles, whereas WT DJ-1 expression completely restored endocytic function in DJ-1 KO neurons. The defective synaptic endocytosis shown in DJ-1 KO neurons may be attributable to alterations in membrane cholesterol level. Thus, DJ-1 appears essential for synaptic vesicle endocytosis and reavailability, and impairment of this function by familial mutants of DJ-1 may be related to the pathogenesis of PD.</P>
Song, Young-Ran,Sung, Su-Kyung,Shin, Eun-Ju,Cho, Chang-Won,Han, Chun-Ji,Hong, Hee-Do MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.9
<P>The edible and medicinal perennial herb <I>Aster scaber</I> is known to have anticancer, antioxidant, and immunomodulatory properties. However, the biological effects of its polysaccharides are not well understood. Here, we aimed to extract novel polysaccharides with enhanced biological properties from <I>Aster scaber</I> using enzyme-assisted methods. Amylase, cellulase, and pectinase were used to extract enzyme-assisted polysaccharide (ASEP)-A, ASEP-C, and ASEP-P, respectively. The yields, physicochemical properties, and immunostimulatory activities of the polysaccharides were investigated and compared with those of hot water extracted polysaccharide (ASWP). The highest yield (3.8%) was achieved for ASEP-P extracted using pectinase digestion. Fourier-transform infrared spectroscopy (FT-IR) and chemical composition analysis revealed that ASWP and three ASEPs were typical acidic heteropolysaccharides, mainly comprising rhamnose, arabinose, galactose, glucose, and galacturonic acid. Immunostimulatory activity assays on RAW264.7 macrophages showed ASEP-P to have the greatest immunostimulatory potential in terms of nitric oxide (NO) and cytokine productions and phagocytic activity. ASEP-P administration improved immune-enhancing effects in normal mice by improving the spleen index and splenic lymphocyte proliferation, and in immunosuppressed mice by modulating lymphocyte proliferation, natural killer (NK) cell activity, and leukocyte counts. The ASEP-P derived from pectinase hydrolysate of <I>Aster scaber</I> demonstrated efficacious immunostimulatory properties and has potential applications as an immune stimulator.</P>
( Won Jai Jung ),( Byung Hoon Park ),( Kyung Soo Chung ),( Song Yee Kim ),( Eun Young Kim ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Se Kyu Kim ),( Joon Chang ),( Moo Suk Park ) 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-
Background: Plasma glucagon in sepsis has scarcely studied. We tried to identify whether glucagon levels were associated with disease severity and mortality in patients with severe sepsis or septic shock. Methods: We evaluated patients with severe sepsis or septic shock admitted to ICU of the university-affiliated hospital in Korea. Plasma levels of glucagon were measured in a total 112 patients (57 survivors and 55 non-survivors) with severe sepsis or septic shock. Results: Compared with the survivors, patients who died in 28 days had significantly higher levels of glucagon on day 0 (admission day), 1, 3, and 7. Glucagon levels were correlated with severity scores (SOFA and APACHE-II). Multivariate analysis identified glucagon levels, presence of septic shock as independent predictors of the overall 28-day mortality rate. Receiver operating characteristic analysis showed that the area under curve of glucagon levels to predict 28-day survival was 0.63 (95% CI=0.52-0.73; P=0.021) as similar as APACHE II. Conclusions: Glucagon levels are related to poor prognosis in patients with severe sepsis.Background: Plasma glucagon in sepsis has scarcely studied. We tried to identify whether glucagon levels were associated with disease severity and mortality in patients with severe sepsis or septic shock. Methods: We evaluated patients with severe sepsis or septic shock admitted to ICU of the university-affiliated hospital in Korea. Plasma levels of glucagon were measured in a total 112 patients (57 survivors and 55 non-survivors) with severe sepsis or septic shock. Results: Compared with the survivors, patients who died in 28 days had significantly higher levels of glucagon on day 0 (admission day), 1, 3, and 7. Glucagon levels were correlated with severity scores (SOFA and APACHE-II). Multivariate analysis identified glucagon levels, presence of septic shock as independent predictors of the overall 28-day mortality rate. Receiver operating characteristic analysis showed that the area under curve of glucagon levels to predict 28-day survival was 0.63 (95% CI=0.52-0.73; P=0.021) as similar as APACHE II. Conclusions: Glucagon levels are related to poor prognosis in patients with severe sepsis.Background: Plasma glucagon in sepsis has scarcely studied. We tried to identify whether glucagon levels were associated with disease severity and mortality in patients with severe sepsis or septic shock. Methods: We evaluated patients with severe sepsis or septic shock admitted to ICU of the university-affiliated hospital in Korea. Plasma levels of glucagon were measured in a total 112 patients (57 survivors and 55 non-survivors) with severe sepsis or septic shock. Results: Compared with the survivors, patients who died in 28 days had significantly higher levels of glucagon on day 0 (admission day), 1, 3, and 7. Glucagon levels were correlated with severity scores (SOFA and APACHE-II). Multivariate analysis identified glucagon levels, presence of septic shock as independent predictors of the overall 28-day mortality rate. Receiver operating characteristic analysis showed that the area under curve of glucagon levels to predict 28-day survival was 0.63 (95% CI=0.52-0.73; P=0.021) as similar as APACHE II. Conclusions: Glucagon levels are related to poor prognosis in patients with severe sepsis.