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HDAC6 regulates thermogenesis of brown adipocytes through activating PKA to induce UCP1 expression
Jung, Suna,Han, Miae,Korm, Sovannarith,Lee, Se-in,Noh, Solhee,Phorl, Sophors,Naskar, Rema,Lee, Kye-Sung,Kim, Geon-Hee,Choi, Yun-Jaie,Lee, Joo-Yong Elsevier 2018 Biochemical and biophysical research communication Vol.503 No.1
<P><B>Abstract</B></P> <P>Mitochondrial uncoupling protein 1 (UCP1) is responsible for nonshivering thermogenesis in brown adipose tissue (BAT). UCP1 increases the conductance of the inner mitochondrial membrane (IMM) for protons to make BAT mitochondria generate heat rather than ATP. HDAC6 is a cytosolic deacetylase for non-histone substrates to regulate various cellular processes, including mitochondrial quality control and dynamics. Here, we showed that the body temperature of HDAC6 knockout mice is slightly decreased in normal hosing condition. Interestingly, UCP1 was downregulated in BAT of HDAC6 knockout mice, which extensively linked mitochondrial thermogenesis. Mechanistically, we showed that cAMP-PKA signaling plays a key role in HDAC6-dependent UCP1 expression. Notably, the size of brown adipocytes and lipid droplets in HDAC6 knockout BAT is increased. Taken together, our findings suggested that HDAC6 contributes to mitochondrial thermogenesis in BAT by increasing UCP1 expression through cAMP-PKA signaling pathway.</P> <P><B>Highlights</B></P> <P> <UL> <LI> HDAC6 regulates thermogenesis of brown adipose tissue. </LI> <LI> cAMP-PKA signaling is responsible for HDAC6-dependent thermogenic regulation to control UCP1 expression. </LI> <LI> HDAC6-dependent regulation of UCP1 affects lipid metabolism in brown adipose tissue. </LI> </UL> </P>
RF-마크네트론 스퍼터링으로 증착된 산화주석 전자수송층의 광학적 및 전기적 특성에 대한 증착 전력의 영향
황지성(Ji Seong Hwang),이원규(Wonkyu Lee),황재근(Jae Keun Hwang),이상원(Sang-Won Lee),현지연(Ji Yeon Hyun),이솔희(Solhee Lee),정석현(Seok Hyun Jeong),강윤묵(Yoonmook Kang),김동환(Donghwan Kim),이해석(Hae-Seok Lee) 한국태양광발전학회 2021 Current Photovoltaic Research Vol.9 No.1
The properties of the electron transport layer (ETL) have a great effect on perovskite solar cell performance. Depositing conformal SnO₂ ETL on bottom textured silicon cells is essential to increase current density in terms of the silicon-perovskite tandem solar cells. In the recent study, the SnO₂ electron transport layer deposited by the sputtering method showed an efficiency of 19.8%. Also, an electron transport layer with a sputtered TiO₂ electron transport layer in a 4-terminal tandem solar cell has been reported. In this study, we synthesized SnOx ETL with a various sputtering power range of 30-60W by Radio-frequency (RF)-magnetron sputtering. The properties of SnOx thin film were characterized using ellipsometer, UV-vis spectrometer, and IV measurement. With a sputtering power of 50W, the solar cell showed the highest efficiency of 13.3%, because of the highest fill factor by the conductivity of SnOx film.