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- 저자 : Soad Z. EL-Emam (검색결과 2 건)
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Middle Eastern Plants with Potent Cytotoxic Effect Against Lung Cancer Cells
Jilan A. Nazeam,Soad Z. EL-Emam 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2
Cancer is one of the leading causes of increasing global mortality with uprising health concerns and threats. Unfortunately, conventional chemotherapy has substantial side effects, limiting its relevance and prompting a quest for safe andefficient alternatives. For thousands of years, plants have provided a rich reservoir for curing a variety of ailments, includingcancer. According to the World Health Organization, medicinal plants would be the best source of medications. However, only25% of drugs in the present pharmacopoeia are derived from plants. Hence, further research into different plants is required tobetter understand their efficacy. Twenty extracts of widely distributed Middle Eastern plants were screened for the cytotoxiceffect against lung cancer cell lines (A549). Eleven plants showed IC50 below 25 lg/mL, consequently, the bioactive extractswere further fractionated by graded precipitation using absolute ethanol. All fraction A (FA; crude polysaccharides precipitate)showed potent IC50, 0.2–5.5 lg/mL except the FA of Brassica juncea, Silybum marianum, and Phaseolus vulgaris, whereas FBfractions (filtrate) of Anastatica hierochuntica, Plantago ovate, Tussilago farfara, and Cucurbita moschata had lower efficacythan other fractions with IC50 values in the range of 0.1–7.7 lg/mL. The fractions of FA Taraxacum officinale and FB Ziziphusspina possess the most potent cytotoxic activity with IC50, 0.2 and 0.1 lg/mL, respectively. Moreover, cell cycle analysis of bothfractions revealed an arrest at G1/S-phase and activation of apoptosis rather than necrosis as the mode of cell death. Therefore, T. officinale and Z. spina fractions may pave the way to manage lung carcinoma as an alternative and complementary food regimen.
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Sweed Nabila M.,Fayez Ahmed M.,El-Emam Soad Z.,Dawoud Marwa H. S. 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.1
Purpose Rosuvastatin calcium (RSC) is a statin which, in addition to its anti-hypercholesteremic effects, was found to have a potential anticancer activity. The target of the present study is to develop self nano-emulsifying drug delivery systems (SNEDDS) loaded with RSC to overcome its poor solubility, and augment its anticancer activity. Methods A combined mixture-process experimental design was chosen for the optimization of SNEDDS by changing its mixture and process components, where the mixture components were the percentage of Smixture (surfactant and co-surfactant) ( X1) and the percentage of oil ( X2). The process components were the ratio of surfactant to co-surfactant ( X3), and the type of surfactant ( X4). Twenty-four formulae were evaluated for % transmittance and saturated solubility. Results The optimized formula ( O1) was selected based on the highest % transmittance and highest drug solubility, where the % transmittance was 99.05 ± 0.09% and the saturated solubility was 80.52 ± 2.57 mg/ml. The optimized formula has a globule size of 17.53 ± 0.89 nm, a zeta potential of − 10.2 ± 0.21 mV, and a cloud point of 88.5 ± 0.54 °C. Transmission electron microscopy demonstrated spherical droplet morphology. In vitro drug release showed remarkable increase in the drug release from the optimized formula as compared to the corresponding standard RSC. The anticancer activity of O1 was evaluated in HepG2 cell-line, where the IC50 value was 16.2 ± 0.23 μg/ml. The optimized formula increased cell death by both apoptosis and necrosis. Conclusion Our results show that the optimized SNEDDS formula is promising for enhancing the anticancer effect of RSC.
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