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Lee, Ji Hyun,Sidharthan, M,Jung, Sang Mok,Jo, Qtae,Rahman, Mohammad M,Shin, Hyun Woung The Academy 2008 Journal of environmental biology Vol.29 No.4
<P>Algal spores respond to many environmental variables, especially to chemical 'cues'. This chemotactic response can be utilized to attract spores, thereby colonization of a new substrata is possible to be influenced. In this attempt, four chemoattractant candidates were screened against spores of Ulva pertusa to reveal their efficiencies. Attachment and subsequent germination of Ulva spores were effectively influenced by these chemoattractant candidates. In particular 100 microg cm2 of D-glucose coating was found to enhance spore attachment by > 150%. Furthermore, field investigations carried out with test panels, clearly indicate the chemoattractive properties of test coatings. In recent years, various anthropogenic activities and natural hazards cause detrimental impacts on the benthic algae and other fishery resources. Artificial reefs have been laid on many coastal regions to increase or restore marine resources. Chemoattractant coatings can be applied on artificial surfaces to increase the colonization of benthic forms. It also can be used in the mariculture devices. Influence of chemoattractants on Ulva spores and fouling biomass estimated on test panels are discussed.</P>
Pump Wavelength Dependence of Photodarkening in Yb-Doped Fibers
Huizi Li,Liling Zhang,Sidharthan, Raghuraman,Ho, Daryl,Xuan Wu,Venkatram, Nalla,Handong Sun,Tianye Huang,Seongwoo Yoo IEEE 2017 Journal of Lightwave Technology Vol.35 No.13
<P>Photodarkening in Yb-doped fibers is known to be dependent of Yb population inversion. In addition to this dependence, we report that pump wavelength selection plays a significant role in photodarkening dynamics. It is found that 976 nm pump source can lead to more severe photodarkening effects than 916 nm pumping at the same inversion levels. This observation is consistent in Yb-doped fibers with various compositions. Our work reveals pump wavelength is another determinant factor of photodarkening besides the inversion level and emphasizes the importance of pump wavelength selection in high power Yb-doped fiber lasers and amplifiers.</P>
Extracellular Trap by Blood Cells: Clinical Implications
R. J. Nija,S. Sanju,Neeraj Sidharthan,Ullas Mony 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.2
BACKGROUND: Extracellular trap formation (ETosis) by various blood cells has been reported. This trap contains DNA, histones and granular proteins which can elicit an innate immune response by entrapping microorganisms. The trap thus formed has been reported to have an involvement in various pathogenic conditions as well. This review focusses on the trap formation by different blood cells, the immune response associated with trap formation and also its role in various clinical conditions. METHOD: An extensive literature survey on ETosis by blood cells from 2003 to 2019 has been done. After going through the literature throughly, in this review we focuses on the trap formation by different blood cell types such as neutrophils, macrophages, eosinophils, basophils, mast cells, plasmacytoid dentritic cells, and monocytes. The mechanism with which it releases trap, the immune response it elicits and ultimately its involvement in various pathogenic conditions are described here. This article extensively covered all the above aspects and finally comprehends in nutshell the various stimuli that are currently known in trigerring the ETosis, its effect and ultimately its role in disease process. RESULTS: A clarity about the extracellular trap formation by various blood cells, mechanism of ETosis, role of Etosis in microbial invasion and in various pathogenic situations by various blood cells have been described here. CONCLUSION: The current understanding about the process of ETosis and its effects has been extensively described here. Along with lot of favourable outcomes, the process of ETosis will lead to lot of pathogenic situations including thrombosis, tumour metastasis and sepsis. Current understanding about ETosis is limited. Indepth understanding of ETosis may have great therapeutic potential in the diagnosis, guiding of therapy and prognostication in various pathogenic situations including infectious conditions, autoimmune disorders and tumors.
ACCUMULATION OF HEAVY METALS IN KOREAN MARINE SEAWEEDS
김신영,유용훈,임치영,진형주,유종수,신현웅,Kim, Sin-Yeong,M.Sidharthan,Yu, Yong-Hun,Im, Chi-Yeong,Jin, Hyeong-Ju,Yu, Jong-Su,Sin, Hyeon-Ung The Korean Society of Phycology 2003 ALGAE Vol.18 No.4
This paper reports that the heavy metal accumulation in marine seaweeds. Algal samples collected from Korean coast were analyzed to determine the concentrations of Cu, Cd, Cr, Zn and Pb. In general, heavy metals were found to be concentrated in many kinds of Korean seaweeds. The concentration levels of accumulated heavy metals in the marine seaweeds was in the following order: Zn > Cu > Cr > Pb > Cd. The concentrations of the heavy metals in the seawater were the highest in Iyajin harbor. Sargassum horneri, a brown alga accumulated high concentrations of Cu (80.66 ${\mu}g{\cdot}g^{-1}$ dw) and Cr (31.54 ${\mu}g{\cdot}g^{-1}$ dw). The high concentrations of heavy metals were accumulated in the brown algae.
Raghuveer Prabhu,Renjitha Bhaskaran,Veena Shenoy,Rema G,Neeraj Sidharthan 대한혈액학회 2016 Blood Research Vol.51 No.2
BackgroundAutoimmune hemolytic anemia (AIHA) is a less recognized, potentially fatal condition. There is a scarcity of data on clinicoserological characteristics and response to therapy concerning this disease from South India.MethodsData for 33 patients with primary AIHA recorded from July 2009 to June 2015 were retro-spectively analyzed for clinical presentation, response to frontline therapy, durability of response, time to next treatment (TTNT), and response to second-line agents.ResultsThe median follow-up period was 50 months. Among 33 patients, 48% of the cases were warm autoimmune hemolytic anemia (WAIHA), 46% were cold agglutinin disease (CAD), and 6% were atypical. Three-fourth of patients had severe anemia (<8 g/dL hemoglobin [Hb]) at onset; younger patients (age <40 yr) had more severe anemia. All of the patients who required treatment received oral prednisolone at 1.5 mg/kg/d as a frontline therapy, and the response rate was 90% (62% complete response [CR] and 28% partial response [PR]). The overall response to corticosteroids in WAIHA and CAD was 87% and 92%, respectively. The median corticosteroid duration was 14 months, and 50% of the patients required second-line agents. Fourteen patients received azathioprine as a second-line agent, and 11 of these patients responded well, with half of them not requiring a third agent. Four patients developed severe infections (pneumonia, sepsis, and soft tissue ab-scess) and two had life-threatening venous thrombosis. One case of death was recorded.ConclusionAIHA is a heterogeneous disease that requires care by physicians experienced in treating these patients.