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RISS 인기검색어
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- 저자 : Siddharth Srivastava (검색결과 3 건)
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RWON Study: The Real-World Walled-off Necrosis Study
Ankush Pawar,Ujjwal Sonika,Manish Kumar,Sundeep Saluja,Siddharth Srivastava 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.6
Background/Aims: The management of walled-off necrosis (WON) has undergone a paradigm shift from surgical to nonsurgicalmodalities. Real-world data on the management of symptomatic WON are scarce. Methods: Prospectively collected data of symptomatic WON cases were retrospectively evaluated. The treatment modalities usedwere medical management alone, percutaneous catheter drainage (PCD) or endoscopic drainage (ED), or a combination of PCD andED. We compared clinical outcome among these modalities. Results: A total of 264 patients were evaluated. The most common indications for drainage were pain and fever. Of the patients,28% was treated with medical therapy alone, 31% with ED, 37% with PCD, and 4% with a combined approach. Technical successand clinical success were achieved in 93% and 91% of patients in the endoscopic arm and in 90% and 81% patients in the PCD arm,respectively (p=0.0004 for clinical success). Lower rates of complications (7% vs. 22%, p=0.005), readmission (20% vs. 34%, p=0.04),and mortality (4% vs. 19%, p=0.0012), and shorter hospital stay (13 days vs. 19 days, p=0.0018) were observed in the endoscopicgroup than in the PCD group. Conclusions: ED of WON is better than PCD and is associated with lower mortality, fewer complications, and shorter hospitalization.
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COVID-19 Rapid Antigen Test: Role in Screening Prior to Gastrointestinal Endoscopy
Ashok Dalal,Ujjwal Sonika,Manish Kumar,Roshan George,Ajay Kumar,Siddharth Srivastava,Sanjeev Sachdeva,Barjesh Chander Sharma 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.4
Background/Aims: The severe acute respiratory syndrome coronavirus 2 pandemic has affected the gastrointestinal (GI) endoscopyunits globally owing to the risk of transmission. We present our data on the use of rapid antigen test (RAT) as a screening tool priorto endoscopy to prevent the transmission of coronavirus disease (COVID-19). Methods: This study was a retrospective analysis of patients who underwent any GI endoscopic procedure from July 2020 to October2020 at a tertiary referral center in New Delhi, India. All patients underwent screening for COVID-19 using RAT, and endoscopywas performed only when the RAT was negative. The data are presented as numbers and percentages. Results: A total of 3,002 endoscopic procedures were performed during the study period. Only one endoscopic procedure wasperformed in a COVID-19 positive patient. A total of 53 healthcare workers were involved in conducting these procedures. Only2 healthcare workers (3.8%) were diagnosed COVID-19 positive, presumably due to community-acquired infection, during thisperiod. Conclusions: The COVID-19 RAT is easily usable as a simple screening tool prior to GI endoscopy during the COVID-19 pandemic.
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Current Status of Stem Cell Treatment for Type I Diabetes Mellitus
Anupama Kakkar,Ashima Sorout,Mahak Tiwari,Pallavi Shrivastava,Poonam Meena,Sumit Kumar Saraswat,Supriya Srivastava,Rajan Datt,Siddharth Pandey 한국조직공학과 재생의학회 2018 조직공학과 재생의학 Vol.15 No.6
BACKGROUND: Diabetes mellitus is a major health concern in current scenario which has been found to affect people of almost all ages. The disease has huge impact on global health; therefore, alternate methods apart from insulin injection are being explored to cure diabetes. Therefore, this review mainly focuses on the current status and therapeutic potential of stem cells mainly mesenchymal stem cells (MSCs) for Type 1 diabetes mellitus in preclinical animal models as well as humans. METHODS: Current treatment for Type 1 diabetes mellitus mainly includes use of insulin which has its own limitations and also the underlying mechanism of diseases is still not explored. Therefore, alternate methods to cure diabetes are being explored. Stem cells are being investigated as an alternative therapy for treatment of various diseases including diabetes. Few preclinical studies have also been conducted using undifferentiated MSCs as well as in vitro MSCs differentiated into b islet cells. RESULTS: These stem cell transplant studies have highlighted the benefits of MSCs, which have shown promising results. Few human trials using stem cells have also affirmed the potential of these cells in alleviating the symptoms. CONCLUSION: Stem cell transplantation may prove to be a safe and effective treatment for patients with Type 1 diabetes mellitus.
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