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손형우 ( Hyeong U Son ),남동윤 ( Dong Yoon Nam ),김민아 ( Min Ah Kim ),차용수 ( Yong Su Cha ),김종명 ( Jong Myung Kim ),신용규 ( Yong Kyu Shin ),이상한 ( Sang Han Lee ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2011 한국식품저장유통학회지 Vol.18 No.6
Angelica keiskei is a perennial herb belonging to the Umbelliferae family. In this study, the whitening effect of A. keiskei extracts was examined through melanogenesis and tyrosinase inhibitory assays. The ethanol extract (50%) significantly inhibited tyrosinase in a concentration-dependent manner. RT-PCR revealed that the extract exhibited decreased expression of tyrosinase, tyrosinase-related protein-1, tyrosinase-related protein-2, and melanocyte-inducing transcription factor. These results suggest that the extract can be used as an ingredient for the development of cosmeceuticals.
손형우 ( Hyeong U Son ),이숙희 ( Suk Hee Lee ),김민아 ( Min A Kim ),박희준 ( Hee Joon Park ),이상한 ( Sang Han Lee ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2012 한국식품저장유통학회지 Vol.19 No.6
복숭아꽃(도화)과 꽃받침(도화악)의 DW 및 에탄올 추출물로부터 미백활성을 측정하였다. ORAC assay에서 공통적으로 복숭아꽃 추출물이 꽃받침에 비해 높은 활성을, 에탄올 추출물이 DW 추출물 보다 상대적으로 활성이 높은 것을 확인하였다. Tyrosinase에 의한 미백활성을 비교하여 본 결과 10 mg/mL 농도를 기준으로 복숭아꽃 DW 추출물: 40%, 에타올 추출물: 32%, 복숭아꽃받침 DW 추출물: 53%, 에탄올 추출물: 43%의 저해율로 복숭아꽃받침 DW 추출물에서 가장 높은 활성을 나타내었다. B16F10 세포에서 melanin생합성 억제를 측정한 결과, 복숭아 꽃 에탄올 추출물의 10 μg/mL에서 57%, 100 mg/mL에서 76%의 억제 효과를, 복숭아 꽃받침 에탄올 추출물의 10 μg/mL에서 63%의 억제 효과를 확인하였다. 이 결과를 토대로 복숭아꽃 및 꽃받침의 물 또는 에탄올 추출물은 다른 천연성분과 적절히 혼합사용 시 우수한 시너지효과를 나타낼 수 있는 소재임을 확인하였다. The antioxidant activity and whitening effect of the distilled water (DW) and ethanol extracts of the Prunus persica flower and calyx were studied. In the oxygen radical absorption capacity (ORAC) assay for antioxidant activity measurement, it was confirmed that the flower extract was stronger than the calyx extract, and that the ethanol extract was relatively stronger than the DW extract. To define the whitening effect, an experiment was conducted involving tyrosinase inhibitory assay and measurement of the melanin content of B16F10. As a result of the use of tyrosinase, the DW extract of calyx showed 53% inhibition as the highest activity. The melanin content inhibitory rates were defined as 57% for the ethanol flower extract and 63% of the ethanol calyx extract, based on a 10 μg/mL concentration. Based on these results, mixture with the whitening effect in the extract of P. persica and another compounds should be researched for development as a cosmetic ingredient.
손형우 ( Hyeong U Son ),허진철 ( Jin Chul Heo ),김숙경 ( Suk Kyung Kim ),권선영 ( Seon Young Kwon ),한길환 ( Gil Hwan Han ),이상한 ( Sang Han Lee ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2011 한국식품저장유통학회지 Vol.18 No.2
The refined chaff liquid smoke purified by the second or third filtering, supplemented with Artemisia extract or Perillae folium extract was investigated by measuring antioxidant and antiatopic activities. In DPPH and FRAP assays, three kinds of chaff liquid smokes had potential in antioxidant activity. Additionally, we assessed for antiatopic activity by using C57BL/6 mice with stimulation of dinitrofluorobenzene and observed that their ear swelling was alleviated by various fractions. Overall, all of the chaff liquid smoke reduced the response of swelling on ear epidermis. Especially, refined chaff liquid smoke supplemented with Perillae folium extract was most active than any other fractions.
김민아 ( Min A Kim ),손형우 ( Hyeong U Son ),윤은경 ( Eun Kyung Yoon ),최용희 ( Yong Hee Choi ),이상한 ( Sang Han Lee ) 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2012 한국식품저장유통학회지 Vol.19 No.3
To investigate the anti-diabetic activity of ethanol and aqueous peel and seed extracts obtained from three different grape species (Cambell Early, MBA, and Kyoho), alpha-glucosidase inhibitory activity was examined. All extracts showed anti-diabetic activity, especially aqueous extract exhibited inhibitory effect above 70%. Thus, we used aqueous extract to check the potential hypoglycemic effects in a streptozotocin (STZ)-induced diabetic mice model. The results showed that the blood glucose level of STZ-induced diabetic mice decreased drastically after 3 hr when the aqueous extract of Cambell Early seed was treated to the mice model. The aqueous extract of Kyoho seed lessened blood glucose level by 60%. Together, these data indicate that extracts of grape peel and seed (aqueous or ethanol) may have potential in improving hypoglycemic effects in the diabetic symptoms, suggesting that further investigation on biomarker expressions should be rewarding.
김민아 ( Min A Kim ),손형우 ( Hyeong U Son ),남동윤 ( Dong Yoon Nam ),차용수 ( Yong Su Cha ),신용규 ( Yong Kyu Shin ),최용희 ( Yong Hee Choi ),이상한 ( Sang Han Lee ) 한국식품저장유통학회(구 한국농산물저장유통학회) 2012 한국식품저장유통학회지 Vol.19 No.5
The purpose of this study was to evaluate the anti-atopic-dermatitis effect of Angelica keiskei extract using a DNFB-induced animal model of atopic-dermatitis symptoms. A. keiskei was prepared via extraction with DW, 50% ethanol, and 100% ethanol in addition to fresh juice. All the extracts reduced the thickness levels of the ears and ear epidermis against swelling by DNFB inducement, especially in the aqueous-extract-treated group. The mRNA expressions of matrix metalloproteinases (MMPs), however, were not observed, which may indicate that Angelica keiskei extract alleviates the atopic-dermatitis symptoms in an MMP-independent manner. Finally, the level of the inflammatory cytokine IL-4 was inhibited only in the juice-treated group, although the IL-13 level was inhibited in the juice-, 50%-ethanol-extract-, and 100%-ethanol-extract-treated groups in a dose-dependent manner, and was not inhibited in the aqueous-extract-treated group. Taken together, these results suggest that Angelica keiskei extract has an inhibitory effect on atopic dermatitis, and may be a useful biomaterial for the development of cosmeceuticals.
연구노트 : 포도 추출물로부터 C/EBP 전사인자 활성 비교
이시림 ( Si Rim Lee ),박철홍 ( Chul Hong Park ),권은영 ( Eun Young Kuan ),루옌칭 ( Yan Qing Lu ),김홍 ( Hong Kim ),김기찬 ( Ki Chan Kim ),손형우 ( Hyeong U Son ),이현진 ( Hyun Jin Lee ),허진철 ( Jin Chul Heo ),이상한 ( Sang Han L 한국식품저장유통학회(구 한국농산물저장유통학회) 2011 한국식품저장유통학회지 Vol.18 No.1
In order to compare what kinds of transcription factors are associated with the inhibition of preadipocyte cell proliferation, we prepared several grape extracts and tested the expression patterns by reverse transcription-polymerase chain reaction. As a result, 50% ethanol extract of Campbell early seed inhibited adipogenesis derived from the MDI solution. Extract of Campbell early seed was significantly inhibited lipid droplet formation and expression of molecular factors C/EBP-alpha and delta in 3T3-L1 cells. It is suggested that grape extracts of fractions would be a good candidate for the development of regional skin fat modulator.