ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment

Po-Wei Lee,Tzu-Yun Wang,Yun-Hsuan Chang,Sheng-Yu Lee,Shiou-Lan Chen,Ze-Cheng Wang,Po See Chen,Chun-Hsien Chu,San-Yuan Huang,Nian-Sheng Tzeng,I Hui Lee,Kao Chin Chen,Yen Kuang Yang,Jau-Shyong Hong,Ru-B 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1

Objective: Patients with opioid use disorder (OUD) have impaired attention, inhibition control, and memory function. The aldehyde dehydrogenase 2 (ALDH2 ) gene has been associated with OUD and ALDH2 gene polymorphisms may affect aldehyde metabolism and cognitive function in other substance use disorder. Therefore, we aimed to investigate whether ALDH2 genotypes have significant effects on neuropsychological functions in OUD patients undergoing methadone maintenance therapy (MMT). Methods: OUD patients undergoing MMT were investigated and followed-up for 12 weeks. ALDH2 gene polymorphisms were genotyped. Connors’ Continuous Performance Test (CPT) and the Wechsler Memory Scale-Revised (WMS-R) were administered at baseline and after 12 weeks of MMT. Multivariate linear regressions and generalized estimating equations (GEEs) were used to examine the correlation between the ALDH2 genotypes and performance on the CPTs and WMS-R. Results: We enrolled 86 patients at baseline; 61 patients completed the end-of-study assessments. The GEE analysis showed that, after the 12 weeks of MMT, OUD patients with the ALDH2 *1/*2+*2/*2 (ALDH2 inactive) genotypes had significantly higher commission error T-scores (p = 0.03), significantly lower hit reaction time T-scores (p = 0.04), and significantly lower WMS-R visual memory index scores (p = 0.03) than did patients with the ALDH2 1 */*1 (ALDH2 active) genotype. Conclusion: OUD patients with the ALDH2 inactive genotypes performed worse in cognitive domains of attention, impulse control, and memory than did those with the ALDH2 active genotype. We conclude that the ALDH2 gene is important in OUD and is associated with neuropsychological performance after MMT.

Implementation and Performance Evaluation of Network-based Virtual Storage Systems on Android Mobile Device

Hui-Shyong Yeo,Hoon-Jae Lee,Hyotaek Lim 한국정보통신학회 2012 2016 INTERNATIONAL CONFERENCE Vol.5 No.1

Hand tracking and gesture recognition system for human-computer interaction using low-cost hardware

Yeo, Hui-Shyong,Lee, Byung-Gook,Lim, Hyotaek Springer-Verlag 2015 MULTIMEDIA TOOLS AND APPLICATIONS Vol.74 No.8

Prevalence, Incidence, and Factor Concentrate Usage Trends of Hemophiliacs in Taiwan

Tsu-Chiang Tu,Wen-Shyong Liou,Tsui-Yun Chou,Tsung-Kun Lin,Chuan-Fang Lee,Jye-Daa Chen,Thau-Ming Cham,Mei-Ing Chung 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.1

Purpose: Hemophilia A and B (HA, HB) are the most common X-linked inherited bleeding disorders. The introduction of factor concentrates has allowed for control of the lifelong chronic disease. However, no studies have been published regarding the epidemiology of hemophilia in Taiwan. Our aim was to determine the prevalence, incidence, and mortality rate, as well as trends in the use of factor concentrates,in individuals with hemophilia in Taiwan. Materials and Methods: A retrospective study was conducted using the National Health Insurance Research Database between 1997 and 2007. Results: We identified 988 males with hemophilia (HA : HB ratio=5.4 : 1). The mean prevalence per 100000 males was 6.7±0.1 for HA and 1.2±0.1 for HB. The estimated mean annual incidence per live male birth was 1 in 10752 for HA and 1 in 47619 for HB. Standardized mortality ratios for males with hemophilia (all severities) or severe hemophilia were 1.3- and 2.1-fold higher than that of the general male population, respectively. Mean factor VIII (FVIII) and factor IX (FIX) usage was 1.5003±0.4029 and 0.3126±0.0904 international units (IUs) per capita, respectively. Mean FVIII and FIX usage per patient with hemophilia (all severities) or severe hemophilia was 44027±11532 and 72341±17298, respectively, and 49407±13015 and 74369±18411 IUs per person with HA or HB, respectively. Conclusion: Our data revealed epidemiologic and factor concentrate usage trends in males with hemophilia in Taiwan, highlighting a need for improvements in the mandatory National Health Insurance registry. A better-designed, patient-centered registry system would enable more detailed patient information collection and analysis, improving subsequent care.

Prevalence, Incidence, and Factor Concentrate Usage Trends of Hemophiliacs in Taiwan

Tsu-Chiang Tu,Wen-Shyong Liou,Tsui-Yun Chou,Tsung-Kun Lin,Chuan-Fang Lee,Jye-Daa Chen,Thau-Ming Cham,Mei-Ing Chung 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.2

Purpose Hemophilia A and B (HA, HB) are the most common X-linked inherited bleeding disorders. The introduction of factor concentrates has allowed for control of the lifelong chronic disease. However, no studies have been published regarding the epidemiology of hemophilia in Taiwan. Our aim was to determine the prevalence, incidence, and mortality rate, as well as trends in the use of factor concentrates, in individuals with hemophilia in Taiwan. Materials and Methods A retrospective study was conducted using the National Health Insurance Research Database between 1997 and 2007. Results We identified 988 males with hemophilia (HA : HB ratio=5.4 : 1). The mean prevalence per 100000 males was 6.7±0.1 for HA and 1.2±0.1 for HB. The estimated mean annual incidence per live male birth was 1 in 10752 for HA and 1 in 47619 for HB. Standardized mortality ratios for males with hemophilia (all severities) or severe hemophilia were 1.3- and 2.1-fold higher than that of the general male population, respectively. Mean factor VIII (FVIII) and factor IX (FIX) usage was 1.5003±0.4029 and 0.3126±0.0904 international units (IUs) per capita, respectively. Mean FVIII and FIX usage per patient with hemophilia (all severities) or severe hemophilia was 44027±11532 and 72341±17298, respectively, and 49407±13015 and 74369±18411 IUs per person with HA or HB, respectively. Conclusion Our data revealed epidemiologic and factor concentrate usage trends in males with hemophilia in Taiwan, highlighting a need for improvements in the mandatory National Health Insurance registry. A better-designed, patient-centered registry system would enable more detailed patient information collection and analysis, improving subsequent care.

Evaluation of glass composites for sealing solid oxide fuel cells

Chun Lin Chu,Jye Lee,Shyong Lee 한양대학교 세라믹연구소 2008 Journal of Ceramic Processing Research Vol.9 No.4

Six metallic alloys, namely, Crofer22, ZMG232, an equivalent ZMG232, stainless steels SS430, SS304 and Inconel718 were investigated. A commercial Asahi Bulk Glass is sealed on these materials and evaluated for oxidation behavior under a hot air environment for various period of time and for thermal expansion. Then the resultant oxide scale was studied; with the microstructure and chemical composition of the crystalline phases investigated by scanning electron microscopy (SEM) and energy dispersive spectroscopic (EDS) analysis. The results show the Asahi bulk glass on ZMG232 was good for compaction and adhesion; no vacancies in the glass. ZMG232 seems to be more suitable for Asahi bulk glass than the other alloys. The glass does not fully crystallize even after long-term heat treatments at 500-600 oC. Sealing glass over a long period of time during operation of a solid oxide fuel cell (SOFC) would generate thermal stresses in the seal and may have adverse effects on its mechanical performance. This may lead to cracking of the seal, resulting in mixing of the fuel and the oxidant gases. Six metallic alloys, namely, Crofer22, ZMG232, an equivalent ZMG232, stainless steels SS430, SS304 and Inconel718 were investigated. A commercial Asahi Bulk Glass is sealed on these materials and evaluated for oxidation behavior under a hot air environment for various period of time and for thermal expansion. Then the resultant oxide scale was studied; with the microstructure and chemical composition of the crystalline phases investigated by scanning electron microscopy (SEM) and energy dispersive spectroscopic (EDS) analysis. The results show the Asahi bulk glass on ZMG232 was good for compaction and adhesion; no vacancies in the glass. ZMG232 seems to be more suitable for Asahi bulk glass than the other alloys. The glass does not fully crystallize even after long-term heat treatments at 500-600 oC. Sealing glass over a long period of time during operation of a solid oxide fuel cell (SOFC) would generate thermal stresses in the seal and may have adverse effects on its mechanical performance. This may lead to cracking of the seal, resulting in mixing of the fuel and the oxidant gases.

Dextromethorphan Protect the Valproic Acid Induced Downregulation of Neutrophils in Patients with Bipolar Disorder

Ru-Band Lu,Yun-Hsuan Chang,Sheng-Yu Lee,Tzu-Yun Wang,Shu-Li Cheng,Po See Chen,Yen Kuang Yang,Jau-Shyong Hong,Shiou-Lan Chen 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1

Objective: Valproic acid (VPA) is an anticonvulsant and commonly long term used as a mood stabilizer for patients with mood disorders. However its chronic effects on the hematological changes were noticed and need to be further evaluated. In this study, we evaluated, in Taiwanese Han Chinese patients with bipolar disorders (BD), the chronic effects of VPA or VPA plus dextromethorphan (DM) on the hematological molecules (white blood cell [WBCs], red blood cells [RBCs], hemoglobin, hematocrit, and platelets). Methods: In a 12-week, randomized, double-blind study, we randomly assigned BD patients to one of three groups: VPA plus either placebo (VPA+P, n = 57) or DM (30 mg/day, VPA+DM30, n = 56) or 60 mg/day (VPA+DM60, n = 53). The Young Mania Rating Scale and Hamilton Depression Rating Scale were used to evaluate symptom severity, and the hematological molecules were checked. Results: Paired t test showed that the WBC, neutrophils, platelets and RBCs were significantly lowered after 12 weeks of VPA+P or VPA+DM30 treatment. VPA+DM60 represented the protective effects in the WBCs, neutrophils, and RBCs but not in the platelets. We further calculated the changes of each hematological molecules after 12 weeks treatment. We found that combination use of DM60 significantly improved the decline in neutrophils induced by the long-term VPA treatment. Conclusion: Hematological molecule levels were lower after long-term treatment with VPA. VPA+DM60, which yielded the protective effect in hematological change, especially in the neutrophil counts. Thus, DM might be adjunct therapy for maintaining hematological molecules in VPA treatment.

Refinement of the Primary Si Particles in Hypereutectic Aluminum Alloy

Chang-Chuan Hsu,Jian-Yih Wang,Jian-Jia Huang,Shyong Lee 대한금속·재료학회 2012 METALS AND MATERIALS International Vol.18 No.4

Al-Si alloys, with such excellent properties as low weight, low thermal expansion coefficient, and high wear-resistance, are ideal materials for the automobile and aerospace industries. However, their applications have been hampered by the coarsening of the primary-Si particles in Al-Si alloys. In this study, simple plastic deformation was used to reduce primary-Si particles and to improve the wear-resistance and mechanical strength of Al-Si alloys. Experimental results showed that mechanical rolling decreased the grain size of primary-Si particles in Al-Si alloys and reduced the variation in silicon particle size. After 60%-roll-reduction, the alloy showed an improved tensile strength of 340 MPa, which is attributed to the work hardening of the aluminum matrix and the dispersion strengthening of the primary-Si particles. Data from wear-resistance testing showed that rolling led to a reduction in wear loss. This improvement in wear resistance is due to the particle size refinement of silicon at a high percentage-roll-reduction.