http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Shweta A. Singh,Hetal Pampaniya,Vikram Kumar,Mukesh Kumar,Shekhar Singh Jadaun,Vivek Yadav,Sanjiv Saigal,Subhash Gupta 대한이식학회 2022 Korean Journal of Transplantation Vol.36 No.2
Background: High-volume centers (HVCs) are classically associated with better out- comes. During the coronavirus disease 2019 (COVID-19) pandemic, there has been a decrease in the regular liver transplantation (LT) activity at our center. This study ana- lyzed the effect of the decline in LT on posttransplant patient outcomes at our HVC. Methods: We compared the surgical outcomes of patients who underwent LT during the COVID-19 pandemic lockdown (April 1, 2020 to September 30, 2020) with outcomes in the pre-pandemic calendar year (April 1, 2019 to March 31, 2020). Results: During the 6 months of pandemic lockdown, 60 patients underwent LT (43 adults and 17 children) while 228 patients underwent LT (178 adults and 50 children) during the pre-pandemic calendar year. Patients in the pandemic group had significant- ly higher model for end-stage liver disease (MELD) scores (24.39±9.55 vs. 21.14±9.17, P=0.034), Child-Turcotte-Pugh scores (11.46±2.32 vs. 10.25±2.24, P=0.03), and inci- dence of acute-on-chronic liver failure (30.2% vs. 10.2%, P=0.002). Despite performing LT in sicker patients with COVID-19-related challenges, the 30-day (14% vs. 18.5%, P=0.479), 3-month (16.3% vs. 20.2%, P=0.557), and 6-month mortality rates (23.3% vs. 28.7%, P=0.477) were lower, but not statistically significant when compared to the pre-pandemic cohort. Conclusions: During the COVID-19 pandemic lockdown the number of LT procedures performed at our HVC declined by half because prevailing conditions allowed LT in very sick patients only. Despite these changes, outcomes were not inferior during the pan- demic period compared to the pre-pandemic calendar year. Greater individualization of patient care contributed to non-inferior outcomes in these sick recipients.
Shweta Prasad,Amitabh Bhattacharya,Lulup Kumar Sahoo,Dhruv Batra,Nitish Kamble,Ravi Yadav,Dwarakanath Srinivas,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.1
There are very significant knowledge gaps and misconceptions regarding DBS among patients with PD and caregivers. Adequate and appropriate education is necessary to clarify these misconceptions to avoid the development of unrealistic expectations and poor satisfaction.
The Non-Motor Symptom Profile of Progressive Supranuclear Palsy
Sudhakar Pushpa Chaithra,Shweta Prasad,Vikram Venkappayya Holla,Albert Stezin,Nitish Kamble,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2020 Journal Of Movement Disorders Vol.13 No.2
ObjectiveaaNon-motor symptoms (NMSs) significantly contribute to increased morbidity and poor quality of life in patients withparkinsonian disorders. This study aims to explore the profile of NMSs in patients with progressive supranuclear palsy (PSP) usingthe validated Non-Motor Symptom Scale (NMSS). MethodsaaSeventy-six patients with PSP were evaluated in this study. Motor symptoms and NMSs were evaluated using the PSPRating Scale (PSPRS), Unified Parkinson’s Disease Rating Scale-III, Montreal Cognitive Assessment, Hamilton Depression (HAMD)and Anxiety Rating Scales, Parkinson’s Disease Sleep Scale (PDSS) and NMSS. NMS severity and prevalence were also comparedbetween patients with PSP-Richardson syndrome (PSP-RS) and those with PSP-parkinsonism. ResultsaaAll subjects in this cohort reported at least 2 NMSs. The most prevalent NMSs in patients with PSP were in the domainsof sleep/fatigue, mood/cognition, and sexual function. The least prevalent NMSs were in the domains of cardiovascular includingfalls, and perceptual problems/hallucinations. Significant correlations were observed between the NMSS scores and HAM-D,PDSS, PSPRS scores and PSPRS sub-scores. The severity of NMSs was unrelated to the duration of illness. Patients with PSP-RSreported a higher severity of drooling, altered smell/taste, depression and altered interest in sex and a higher prevalence of sexualdysfunction. ConclusionaaNMSs are commonly observed in patients with PSP, and the domains of sleep, mood and sexual function aremost commonly affected. These symptoms contribute significantly to disease morbidity, and clinicians should pay adequate attentionto identifying and addressing these symptoms.
Clinical and Imaging Profile of Patients with Joubert Syndrome
Bharath Kumar Surisetti,Vikram Venkappayya Holla,Shweta Prasad,Koti Neeraja,Nitish Kamble,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.3
Nine patients were included in the study. All patients had facial dysmorphism and ocular abnormalities, and 4 patients had dystonia. Ocular tilt reaction and alternate skew deviation (66%) were the most common ocular abnormalities. Horizontally aligned superior cerebellar peduncles were observed in all four patients with diffusion tensor imaging, with a lack of decussation in three. Exome sequencing performed in four patients revealed novel variants in the MKS1, CPLANE1, and PIBF1 genes.
Sialidosis type I without cherry red spot – Is there a genetic basis?
Koti Neeraja,Vikram Venkappayya Holla,Shweta Prasad,Bharath Kumar Surisetti,Kempaiah Rakesh,Nitish Kamble,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.1
Sialidosis is an inborn error of metabolism due to a defect in the NEU1 gene and manifests as two phenotypes: mild type I and severe type II. The cherry red spot (CRS) is a characteristic feature in both types of sialidosis; reports of sialidosis without a CRS are rare. We report two cases of genetically confirmed sialidosis type I with a typical presentation of progressive cortical myoclonus and ataxia but without the CRS. A previously reported homozygous pathogenic variant p.Arg294Cys was detected in the first case, and a novel homozygous pathogenic variant p.Arg305Pro was detected in the second case. Additionally, we reviewed the literature describing cases with similar mutations to find a genetic basis for the absence of a CRS. Milder mutation of both alleles detected in both patients may be the reason for the absence of a CRS.
Interrogation of earthworm (Clitellata: Haplotaxida) taxonomy and the DNA sequence database
Nalini Tiwari,Azhar Rashid Lone,Samrendra Singh Thakur,Shweta Yadav 국립중앙과학관 2021 Journal of Asia-Pacific Biodiversity Vol.14 No.1
The DNA sequence database assists us with great potential in species identification because it is practicaland affordable to perform. More often, the identification using molecular data helps to identifymorphologically variable individuals of same species, including juvenile specimens. In case of earthworms,the classical standards of taxonomy are mainly based on genital structures, while the collectionof the sexually agile worm is difficult. Hence, typical barcode marker cytochrome c oxidase subunit 1 wasused to explore species richness of the study area. From taxonomic relationship, the valid identificationof voucher specimens was taken into consideration for characterization. The species richness of earthwormsp. viz., Metaphire houlleti, Perionyx sp., Drawida minuta, Eudichogaster prashadi, Lennogasterpusillus, Octochaetona beatrix, and Octochaetona prashadi were recorded and analyzed. Less than 1%divergence within species was found, whereas divergence between species was greater than 15% in allcases. The phylogenetic tree(s) was constructed using the best-fitted substitution model of evolution andspecies delimitation by Automatic Barcode Gap Discovery, operational taxonomic units, and networkanalysis. The prospective and limitations of molecular taxonomy and the vital role of publicly availablenucleotide sequence databases were reviewed to inventor earthworm diversity. The study shows theuniversality of single locus persists utopian and the use of other typical loci may strengthen earthwormdiversity assessment.
Deep Brain Stimulation Battery Exhaustion during the COVID-19 Pandemic: Crisis within a Crisis
Vikram Venkappayya Holla,Koti Neeraja,Bharath Kumar Surisetti,Shweta Prasad,Nitish Kamble,Dwarakanath Srinivas,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2020 Journal Of Movement Disorders Vol.13 No.3
The novel coronavirus disease (COVID-19) pandemic and public health measures to control it have resulted in unique challenges in the management of patients with deep brain stimulation (DBS). We report our experience with the management of acute worsening of symptoms due to battery exhaustion in 3 patients with DBS.
Azhar Rashid Lone,Nalini Tiwari,Samrendra Singh Thakur,Oren Pearlson,Tomáš Pavlíček,Shweta Yadav 국립중앙과학관 2020 Journal of Asia-Pacific Biodiversity Vol.13 No.2
The present investigation was carried out on the earthworms collected from the reserve forests ofMeghalaya, which is a part of the North Eastern Region of India, a hot spot of biodiversity to assessdiverse earthworms. We adopted integrative approaches involving morphoanatomical taxonomy andcytochrome oxidase 1 sequences using DNA barcoding technique to discriminate different species ofKanchuria genus. The exploration revealed the presence of six Kanchuria species among which four arenew: Kanchuria daribokgrensis sp nov, Kanchuria karorensis sp nov, Kanchuria makhulensis sp nov, andKanchuria mohiskulensis sp nov. Moreover, the species of Kanchuri turaensis and Kanchuri octotheca wereadditionally identified. The maximum intraspecific and minimum interspecific divergence of six Kanchuriaspecies recorded were 6.11% and 14.85%, respectively. The neighbor-joining tree was constructedusing the K2P substitution model, and species discovery was achieved by Automatic Barcode Gap Discoveryand Barcode Index Number analysis. The study presented the detailed descriptions and illustrationsof six species including four new species of Kanchuria supplemented with their DNA barcodesfrom Meghalaya (North Eastern Region) to facilitate future species identification.