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Thavasimuthu Nisha Mol,Nitish Kamble,Vikram V. Holla,Rohan Mahale,Pramod Kumar Pal,Ravi Yadav 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.2
ObjectiveaaThere is limited literature on the knowledge, attitude, and perceptions (KAP) of botulinum toxin (BoNT) treatmentamong patients and caregivers. The objective of this study was to assess the KAP in patients undergoing BoNT treatment for movementdisorders. MethodsaaOne hundred patients with movement disorders from National Institute of Mental Health and Neurosciences Hospitalin Bengaluru, South India, were recruited. The patients underwent demographic, clinical, and Patient Knowledge Questionnaireon Botulinum Toxin Use in Movement Disorders (PKQ-BMD)-based evaluations. ResultsaaThe mean age of patients at the time of presentation was 47.97 ± 14.19 years (range, 12–79). Of all the patients, 26 (28%)patients were anxious, and 86% of these patients were reassured after appropriate counseling. There were 83 (89%) patients whofound BoNT to be a costlier option. Education and previous Internet searches influenced positive performance in the “knowledge”domain and overall PKQ-BMD scores. The “number of injections” was also positively correlated with KAP performance. ConclusionaaThis study showed that knowledge and perceptions about BoNT treatment need to be further improved. Wideravailability of the Internet has provided a positive impact on patients’ and carers’ KAP. Internet-based information, higher educationalqualifications of the patients, and a higher number of BoNT injection sessions are the most important predictors of satisfactoryKAP related to BoNT injection treatment in patients with movement disorders
Deep Brain Stimulation Battery Exhaustion during the COVID-19 Pandemic: Crisis within a Crisis
Vikram Venkappayya Holla,Koti Neeraja,Bharath Kumar Surisetti,Shweta Prasad,Nitish Kamble,Dwarakanath Srinivas,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2020 Journal Of Movement Disorders Vol.13 No.3
The novel coronavirus disease (COVID-19) pandemic and public health measures to control it have resulted in unique challenges in the management of patients with deep brain stimulation (DBS). We report our experience with the management of acute worsening of symptoms due to battery exhaustion in 3 patients with DBS.
Clinical and Imaging Profile of Patients with Joubert Syndrome
Bharath Kumar Surisetti,Vikram Venkappayya Holla,Shweta Prasad,Koti Neeraja,Nitish Kamble,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.3
Nine patients were included in the study. All patients had facial dysmorphism and ocular abnormalities, and 4 patients had dystonia. Ocular tilt reaction and alternate skew deviation (66%) were the most common ocular abnormalities. Horizontally aligned superior cerebellar peduncles were observed in all four patients with diffusion tensor imaging, with a lack of decussation in three. Exome sequencing performed in four patients revealed novel variants in the MKS1, CPLANE1, and PIBF1 genes.
The Non-Motor Symptom Profile of Progressive Supranuclear Palsy
Sudhakar Pushpa Chaithra,Shweta Prasad,Vikram Venkappayya Holla,Albert Stezin,Nitish Kamble,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2020 Journal Of Movement Disorders Vol.13 No.2
ObjectiveaaNon-motor symptoms (NMSs) significantly contribute to increased morbidity and poor quality of life in patients withparkinsonian disorders. This study aims to explore the profile of NMSs in patients with progressive supranuclear palsy (PSP) usingthe validated Non-Motor Symptom Scale (NMSS). MethodsaaSeventy-six patients with PSP were evaluated in this study. Motor symptoms and NMSs were evaluated using the PSPRating Scale (PSPRS), Unified Parkinson’s Disease Rating Scale-III, Montreal Cognitive Assessment, Hamilton Depression (HAMD)and Anxiety Rating Scales, Parkinson’s Disease Sleep Scale (PDSS) and NMSS. NMS severity and prevalence were also comparedbetween patients with PSP-Richardson syndrome (PSP-RS) and those with PSP-parkinsonism. ResultsaaAll subjects in this cohort reported at least 2 NMSs. The most prevalent NMSs in patients with PSP were in the domainsof sleep/fatigue, mood/cognition, and sexual function. The least prevalent NMSs were in the domains of cardiovascular includingfalls, and perceptual problems/hallucinations. Significant correlations were observed between the NMSS scores and HAM-D,PDSS, PSPRS scores and PSPRS sub-scores. The severity of NMSs was unrelated to the duration of illness. Patients with PSP-RSreported a higher severity of drooling, altered smell/taste, depression and altered interest in sex and a higher prevalence of sexualdysfunction. ConclusionaaNMSs are commonly observed in patients with PSP, and the domains of sleep, mood and sexual function aremost commonly affected. These symptoms contribute significantly to disease morbidity, and clinicians should pay adequate attentionto identifying and addressing these symptoms.
Shweta Prasad,Amitabh Bhattacharya,Lulup Kumar Sahoo,Dhruv Batra,Nitish Kamble,Ravi Yadav,Dwarakanath Srinivas,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.1
There are very significant knowledge gaps and misconceptions regarding DBS among patients with PD and caregivers. Adequate and appropriate education is necessary to clarify these misconceptions to avoid the development of unrealistic expectations and poor satisfaction.
Sialidosis type I without cherry red spot – Is there a genetic basis?
Koti Neeraja,Vikram Venkappayya Holla,Shweta Prasad,Bharath Kumar Surisetti,Kempaiah Rakesh,Nitish Kamble,Ravi Yadav,Pramod Kumar Pal 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.1
Sialidosis is an inborn error of metabolism due to a defect in the NEU1 gene and manifests as two phenotypes: mild type I and severe type II. The cherry red spot (CRS) is a characteristic feature in both types of sialidosis; reports of sialidosis without a CRS are rare. We report two cases of genetically confirmed sialidosis type I with a typical presentation of progressive cortical myoclonus and ataxia but without the CRS. A previously reported homozygous pathogenic variant p.Arg294Cys was detected in the first case, and a novel homozygous pathogenic variant p.Arg305Pro was detected in the second case. Additionally, we reviewed the literature describing cases with similar mutations to find a genetic basis for the absence of a CRS. Milder mutation of both alleles detected in both patients may be the reason for the absence of a CRS.