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- 저자 : Shusheng Zhu (검색결과 2 건)
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Guanfeng Zheng,Qingtai Xiao,Shusheng Zhu,Hua Wang,Jian Geng,Shuang Zhao,Junwei Huang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.7
The relationship between heat transfer effect and influencing factors in direct contact with evaporator isstudied. It is important to optimize the design and setting of direct contact heat exchangers and further improve theheat transfer process of heat exchangers by understanding the influencing factors of direct contact evaporator. Themethods used are grey correlation analysis, variational mode decomposition and least square support vector machinealgorithm to calculate the experimental heat transfer coefficient. The conclusions are that grey relation analysis can findthe complex relationship between different influencing factors and reduce the amount of data to improve the accuracyof prediction. Hence, the novelty of this paper is to propose a simple, efficient and accurate hybrid prediction model forVHTC prediction. The place where it goes beyond previous efforts in the literature is that different influencing factorson the heat transfer performance in the direct contact heat transfer process are considered. The results show that theprediction accuracy of the heat transfer coefficient can be improved by 7% by optimizing the data only with grey correlationanalysis. The prediction accuracy can be improved up to 53% after using the hybrid model.
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( Xiaoyu Zhang ),( Hang Zheng ),( Hong-yan Zhu ),( Shufen Hu ),( Shusheng Wang ),( Xinghong Jiang ),( Guang-yin Xu ) 대한소화기기능성질환·운동학회 2016 Journal of Neurogastroenterology and Motility (JNM Vol.22 No.2
Background/Aims This study was to investigate whether transforming growth factor-β1 (TGF-β1) plays a role in hyperalgesia in chronic pancreatitis (CP) and the underlying mechanisms. Methods CP was induced in male adult rats by intraductal injection of trinitrobenzene sulfonic acid (TNBS). Abdominal hyperalgesia was assessed by referred somatic behaviors to mechanical stimulation of rat abdomen. Dil dye injected into the pancreas was used to label pancreas-specific dorsal root ganglion (DRG) neurons. Whole cell patch clamp recordings and calcium imaging were performed to examine the effect of TGF-β1 on acutely isolated pancreas-specific DRG neurons. Western blot analysis was carried out to measure the expression of TGF-β1 and its receptors. Results TNBS injection significantly upregulated expression of TGF-β1 in the pancreas and DRGs, and TGF-β1 receptors in DRGs (T9-T13) in CP rats. Intrathecal injection of TGF-β receptor I antagonist SB431542 attenuated abdominal hyperalgesia in CP rats. TGF-β1 application depolarized the membrane potential and caused firing activity of DRG neurons. TGF-β1 application also reduced rheobase, hyperpolarized action potential threshold, and increased numbers of action potentials evoked by current injection of pancreas-specific DRG neurons. TGF-β1 application also increased the concentration of intracellular calcium of DRG neurons, which was inhibited by SB431542. Furthermore, intrathecal injection of TGF-β1 produced abdominal hyperalgesia in healthy rats. Conclusions These results suggest that TGF-β1 enhances neuronal excitability and increases the concentration of intracellular calcium. TGF-β1 and its receptors are involved in abdominal hyperalgesia in CP. This and future study might identify a potentially novel target for the treatment of abdominal pain in CP. (J Neurogastroenterol Motil 2016;22:333-343)
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