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        Event-triggered Asynchronous Filter of Switched Nonlinear Positive Systems

        Shitao Zhang,Xianglei Jia,Junfeng Zhang,Peng Lin 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.2

        This paper is concerned with the event-triggered nonlinear filter (ETNF) problem of switched nonlinear positive systems (SNPSs) under asynchronous switching. The nonlinearities of the systems are located into several sector fields. Under a 1-norm inequality-based event-triggering condition, the augmented filter error systems are established by considering the subsystems and the corresponding filters in the matched and mismatched time intervals. Multiple copositive Lyapunov functions (MCLFs) associated with an average dwell time (ADT) switching are employed for the systems. A nonlinear asynchronous filter based on event-triggering mechanism is constructed for the underlying systems with nonlinear disturbance in terms of the matrix decomposition technique. The novelties contain three aspects: (i) A nonlinear filter is constructed for SNPSs, (ii) A linear programming (LP)-based filter gain design approach is introduced, and (iii) An event-triggering mechanism is developed for SNPSs. Finally, one example is given to verify the effectiveness of the obtained results.

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        Transportation efficiency of insulin loaded in agarose-grafting-hyaluronan microparticle crossing Coca-2 cell monolayer

        JianYan Huang,Lingmin Zhang,Peng Chen,Shitao Chen,Yueheng Wu,ShunQing Tang 한국물리학회 2011 Current Applied Physics Vol.11 No.3

        Agarose-grafting-hyaluronan (Ag-g-HA) has been proved to be a potential carrier for oral insulin, but it needs to clarify that insulin loaded in Ag-g-HA microparticle is effectively transported across epithelial layer. In this paper, Caco-2 cell monolayer was used for imitation of epithelial layer in small intestine to evaluate Ag-g-HA copolymer enhanced insulin transportation crossing epithelial layer. Ag-g-HA/insulin polyelectrolyte complexes were formed via electrostatic interaction at pH 3e5.4 and could spontaneously form microparticles with average diameter of 2 μm. Caco-2 cells in transwell dish were attached in tight monolayer after 21 d proliferation, and some features of Caco-2 cell monolayer, such as trans-epithelial electrical resistance (TEER) value being over 400 Ω/cm^2, alkaline phosphatase (ALP) activity being 0.7184 ± 0.095, and apparent permeability coefficient value (Papp) of propranonol being 1 × 10^-6 cm/s,were similar to those of epithelial layer in small intestine. These results revealed that Caco-2 cellmonolayer was suitable to be a model of small intestine epithelium layer for imitation of insulin crossing small intestine. P_app of insulin crossing Caco-2 monolayer reached 0.592 ± 0.067 × 10^-6 cm/s, which was significantly greater than the control groups. This meant Ag-g-HA as insulin carrier significantly promoted insulin crossing Caco-2 cell monolayer. These findings demonstrate that Caco-2 cell monolayer is a suitable model for drug transportation crossing epithelial layer, and Ag-g-HA has a promise as oral insulin carrier.

      • KCI등재

        Lignin-based sulfonated carbon as an efficient biomass catalyst for clean benzylation of benzene ring compounds

        Xiangyun Chen,Zexiao Zhang,Bing Yuan,Fengli Yu,Congxia Xie,Shitao Yu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.111 No.-

        Low-temperature carbonization–sulfonation two-step process or one-step sulfonation process wasemployed to draft sodium lignosulfonate (SLS), the primary biological macromolecule ingredient ofpapermaking black liquor, into lignin-based sulfonated carbon. The two-step lignin-based sulfonated carbonnamed SLC400,1S was found to be an efficient catalyst for clean Benzyl-alcohol (BA) route Friedel-Crafts (F-C) benzylation of benzene ring compounds. FT-IR, XRD, Raman spectra, XPS, SEM with EDXmapping,TGA-DSC, acid-base titration, and n-butylamine–acetonitrile titration characterizations demonstratedthat the specific two-step process could introduce porous properties and a large number of surfacesulfonic, hydroxyl, and carboxyl active groups into the structure of the prepared material, which wasfound to account for the good catalytic performance for benzylation. Similar to that of hierarchical mesoporousZSM-5 under optimal conditions, the apparent activation energy for benzylation of paraxylene(PX) with BA over SLC400,1S was estimated to be 119 kJmol1. The common by-product of BA route benzylation,dibenzyl ether (DBE), was almost inhibited because of the extraordinary activity of SLC400,1S andthe optimized reaction conditions. A 12-run recycling test demonstrated easy recovery and steadyreusability of the above lignin-based sulfonated carbon catalyst.

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