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Du Baohong,Shi Fengling,Gao Guiping,Cai Liyan 한국초지조사료학회 2009 한국초지조사료학회 학술대회논문집 Vol.2009 No.08
The root crown of forage legume is an important organ which connects underground root system and aboveground branches. And its morphological characteristic is closely related to yield of grass, overwintering ability, regeneration in spring and sustainable productivity of Medicago sativa L. Therefore, in order to understand the morphological mechanism on cold resistance of the root of Melilotoides ruthenica (L.) Sojak t㏊t is a relative species of M sativa, the root morphology of different growth years' M ruthenica had been observed and analyzed. It aims to provide theoretical basis to M. sativa genetic improvement.
Qin Pan,Qilong Wang,Fengling Luo,Min Li,Xianru Xia Dongdong Shi,Xiao-Lian Zhang 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
Tuberculosis (TB) has been a major world-wide cause of death for centuries. One-third of the world’s population is infected with Mycobacterium tuberculosis (M.tb), the etiologic agent of TB. The development of potent new anti-TB drugs is urgently needed. The major M.tb surface lipoglycans, mannose-capped Lipoarabinomannan (ManLAM) had immunosuppressive effects during M.tb infection. In this study, aptamer ZXL1 which specifically bound to ManLAM from the virulent strain M.tb H37Rv was screened out by Systematic Evolution of Ligands by EXponential enrichment (SELEX). The binding affinity of ZXL1 to ManLAM was measured as 8.907X10-8 M of quilibrium dissociation constant (Kd) value by surface plasmon resonance (SPR) analysis. We found that aptamer ZXL1 prevented the ManLAM-induced immunosuppressive effects on DCs and inhibited M. tb entry into macrophages. More importantly, we found that single injection of aptamer ZXL1 significantly prolonged the survival rate of infected mice, and prevent the infected rhesus monkeys from weight loss. The Bacterial numbers were significantly lower in the lungs and spleens in ZXL1-treated groups. These results suggest that aptamer ZXL1 can be used as antimycobacterial agent or as TB vaccine adjuvent.