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RISS 인기검색어
- 검색키워드
- 저자 : Shengchun Liu (검색결과 4 건)
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The synthesis of MDMO-PPV capped PbS nanorods and their application in solar cells
Zhijie Wang,Shengchun Qu,Xiangbo Zeng,Junpeng Liu,Changsha Zhang,Mingji Shi,Furui Tan,Zhanguo Wang 한국물리학회 2009 Current Applied Physics Vol.9 No.5
Poly[2-methoxy-5-(3',7'-dimethyloctyloxy)-1,4-phenylenevinylene] (MDMO-PPV) capped PbS nanorods about 100 nm in diameter and 400 nm in length were synthesized via a hydrothermal route in toluene and dimethylsulfoxide solution. By blending the PbS nanorods with the MDMO-PPV as the active layer, bulk heterojunction solar cells with an indium tin oxide (ITO)/polyethylenedioxythiophene/polystyrenesulphonate (PEDOT: PSS)/MDMO-PPV: PbS nanorods/Al structure were fabricated in a N2 filled glove box. Current density–voltage characterization of the devices showed that the solar cells with PbS nanorods hybrid with MDMO-PPV as active layer were better in performance than the devices with the polymer only.
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Ting Yang,Yuan Yang,Shengchun Liu 한국유방암학회 2015 Journal of breast cancer Vol.18 No.3
Purpose: Metformin may be associated with a decreased risk of breast cancer. We performed a meta-analysis to assess the effect of metformin intake on breast cancer risk and mortality. Methods: We performed a PubMed and EMbase search for all available studies that described the risk of breast cancer and all-cause mortality in relation to the use of metformin among patients with type 2 diabetes mellitus. Pooled relative risks (RRs) were determined using a random effects model to assess the strength of association between metformin and the risk of breast cancer. Results: Fifteen articles from PubMed satisfied the inclusion criteria, including a total of 838,333 participants. Compared with the control group, metformin use was not related to a reduced incidence of breast cancer (RR, 0.964; 95% confidence interval [CI], 0.761−1.221; p=0.761). However, metformin therapy was associated with decreased all-cause mortality (RR, 0.652; 95% CI, 0.488−0.873; p=0.004). No obvious publication bias was detected (incidence: pBegg=0.755, pEgger=0.008; mortality: pBegg=0.072, pEgger=0.185). Conclusion: The present study suggested that metformin therapy may decrease the all-cause mortality of patients affected by breast cancer. However, this finding should be considered carefully and confirmed with further studies.
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Expression of proline-rich protein 15 in breast cancer and its effect on cell biological function
Jiao Tian,Yingzi Zhang,Chi Qu,Han Li,Shengchun Liu 한국고분자학회 2023 Macromolecular Research Vol.31 No.12
PRR15, a member of the proline-rich protein family, has been linked to a better prognosis in breast cancer patients and is highly expressed in a variety of cancer tissues. However, further research must be done on its biological role in breast cancer and its expression. The purpose of this work is to investigate the role of PRR15 in the proliferation, migration, and apoptosis of breast cancer cells as well as to confirm the differential expression of PRR15 in various subtypes of breast cancer tissues and cells. To analyse the differential expression of PRR15 in paracancerous tissues and various types of breast cancer tissues, GEPIA, Kaplan–Meier plotter, GEO, TCGA, and other bioinformatics websites and public databases were used. PRR15 expression in breast cancer tissue was significantly higher than that in normal breast tissue, and PRR15 expression in ER + breast cancer was significantly higher than that in ER- breast cancer. The results were confirmed by RT-PCR, Western Using molecular cloning, plasmids were created to produce cells that over express PRR15. Experiments on how cells behave showed that PRR15 overexpression had no impact on the growth, migration, or death of ER+ and ER− breast cancer cells when compared to control cells. Furthermore, the biological behavior of ER + breast cancer cells was unaffected by PRR15 knockdown.
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Fanli Qu,Rui Chen,Yang Peng,Ying Ye,Zhenrong Tang,Yihua Wang,Beige Zong,Haochen Yu,Shengchun Liu 한국유방암학회 2020 Journal of breast cancer Vol.23 No.3
Purpose: Effective predictors of the response to neoadjuvant chemotherapy (NAC) are still insufficient. This study aimed to investigate the predictive value of serum lipid profiles for the response to NAC in breast cancer patients. Methods: A total of 533 breast cancer patients who had received NAC were retrospectively studied. The pretreatment of serum lipids, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and lipoprotein-α, and clinicopathological characteristics were collected to assess their predictive roles. Results: Breast cancer patients had significantly lower TC, TG, HDL-C, and LDL-C levels than normal individuals. Among these indicators, TG and LDL-C levels and HDL-C level increased and decreased significantly after NAC, respectively. In estrogen receptor (ER)-positive patients, increased LDL-C level was associated with better outcomes. Moreover, the receiver operating characteristic curve analyses suggested that TG and HDL-C levels at diagnosis can be used as predictors of the response to NAC only in the ER-positive subgroup. According to univariate analyses, patients with low TG level (< 1.155 mmol/L) or high HDL-C level (≥ 1.305 mmol/L) in the ER-positive subgroup had more favorable clinical responses than the other patients in the subgroup. Furthermore, according to multivariate analyses, a high HDL-C level (≥ 1.305 mmol/L, p = 0.007) was an independent predictor of NAC efficacy. Conclusion: High HDL-C level (≥ 1.305 mmol/L) before NAC and increased LDL-C level after NAC were associated with the better treatment response in ER-positive breast cancer patients. These results are potentially considered beneficial in establishing treatment decisions.
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