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- 저자 : Shen Manman (검색결과 3 건)
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Taocun Dou,Manman Shen,Meng Ma,Liang Qu,Yongfeng Li,Yuping Hu,Jian Lu,Jun Guo,Xingguo Wang,Kehua Wang 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.3
Objective: Internal organs indirectly affect economic performance and well-being of animals. Study of internal organs during later layer period will allow full utilization of layer hens. Hence, we conducted a genome-wide association study (GWAS) to identify potential quantitative trait loci or genes that potentially contribute to internal organ weight. Methods: A total of 1,512 chickens originating from White Leghorn and Dongxiang Blue-Shelled chickens were genotyped using high-density Affymetrix 600 K single nucleotide polymorphism (SNP) array. We conducted a GWAS, linkage disequilibrium analysis, and heritability estimated based on SNP information by using GEMMA, Haploview and GCTA software. Results: Our results displayed that internal organ weights show moderate to high (0.283 to 0.640) heritability. Variance partitioned across chromosomes and chromosome lengths had a linear relationship for liver weight and gizzard weight (R2 = 0.493, 0.753). A total of 23 highly significant SNPs that associated with all internal organ weights were mainly located on Gallus gallus autosome (GGA) 1 and GGA4. Six SNPs on GGA2 affected heart weight. After the final analysis, five top SNPs were in or near genes 5-Hydroxytryptamine receptor 2A, general transcription factor IIF polypeptide 2, WD repeat and FYVE domain containing 2, non-SMC condensin I complex subunit G, and sonic hedgehog, which were considered as candidate genes having a pervasive role in internal organ weights. Conclusion: Our findings provide an understanding of the underlying genetic architecture of internal organs and are beneficial in the selection of chickens.
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DNA hypermethylation level of ACTL6A may promote BmNPV infection in B. mori
Chen Zikang,Huang Haoling,Yin Haotong,Shen Manman,Guo Xijie,Wuping Liao 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.2
Bombyx mori nucleopolyhedrosis virus (BmNPV) can cause acute virus disease in silkworm, seriously endan gering the sustainable development of sericultural industry. DNA methylation is an extensive regulation mode of gene expression in epigenetics, which plays an important role in a series of life processes such as genomic imprinting, embryo development, aging and viral infection. Previously, we found the DNA hypermethylation of actin-like protein 6A gene (ACTL6A) in BmNPV-infected midgut of silkworm larvae by whole genome bisulfite sequencing. In this study, firstly, we validated the enhanced transcription level and the DNA methylation level of ACTL6A in the midgut upon BmNPV infection by qRT-PCR and BS-PCR, respectively. Then, treated the BmN cells with DNA methylation inhibitor (Zebularine), both the DNA methylation level and the transcription level of ACTL6A were declined. Further, knock down of ACTL6A by siRNA inhibited the proliferation of BmNPV. The results showed that BmNPV infection may induce the DNA hypermethylation of ACTL6A in Bombyx mori, which promoted the transcription level of ACTL6A, and then affected the proliferation of BmNPV. Our results may provide an insight into exploring the role of DNA methylation in the interaction between BmNPV and silkworm.
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Genetic evaluation of eggshell color based on additive and dominance models in laying hens
Guo Jun,Wang Kehua,Qu Liang,Dou Taocun,Ma Meng,Shen Manman,Hu Yuping 아세아·태평양축산학회 2020 Animal Bioscience Vol.33 No.8
Objective: Eggshells with a uniform color and intensity are important for egg production because many consumers assess the quality of an egg according to the shell color. In the present study, we evaluated the influence of dominant effects on the variations in eggshell color after 32 weeks in a crossbred population. Methods: This study was conducted using 7,878 eggshell records from 2,626 hens. Heritability was estimated using a univariate animal model, which included inbreeding coefficients as a fixed effect and animal additive genetic, dominant genetic, and residuals as random effects. Genetic correlations were obtained using a bivariate animal model. The optimal diagnostic criteria identified in this study were: L* value (lightness) using a dominance model, and a* (redness), and b* (yellowness) value using an additive model. Results: The estimated heritabilities were 0.65 for shell lightness, 0.42 for redness, and 0.60 for yellowness. The dominance heritability was 0.23 for lightness. The estimated genetic correlations were 0.61 between lightness and redness, –0.84 between lightness and yellowness, and –0.39 between redness and yellowness. Conclusion: These results indicate that dominant genetic effects could help to explain the phenotypic variance in eggshell color, especially based on data from blue-shelled chickens. Considering the dominant genetic variation identified for shell color, this variation should be employed to produce blue eggs for commercial purposes using a planned mating system.
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