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Fluorescent carbon nanoparticle derived from hyaluronic acid for cancer targeted imaging
( Shazid Md. Sharker ),김성한,이해신,박성영 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
Cancer targeted biocompatible bio-imaging carrier has the potential to revolutionized diagnosis and therapy. To address these potentialities, we report in situ synthesis of hyaluronic acid fluorescent carbon nanoparticle (HA-FCN) and fluorescent carbon nanoparticle (FCN) obtain from the controlled carbonization method using the biocompatible hyaluronic acid (HA). The FCN with remaining HA (HA-FCN) and without identification of remaining HA (FCN) both showed aqueous solubility and small particle size (<20 nm) with different in fluorescence intensity. Without typical conjugation, HA-FCN itself appeared for the trigger targeted bioimaging for the probe. These findings speculate outstanding features in new drug delivery, sensors, diagnostic tools and different biomedical application.
In situ synthesis of luminescent carbon nanoparticles toward target bioimaging.
Sharker, Shazid Md,Kim, Sung Min,Lee, Jung Eun,Jeong, Ji Hoon,In, Insik,Lee, Kang Dea,Lee, Haeshin,Park, Sung Young RSC Pub 2015 Nanoscale Vol.7 No.12
<P>This paper describes the in situ synthesis of single fluorescence carbon nanoparticles (FCNs) for target bioimaging applications derived from biocompatible hyaluronic acid (HA) without using common conjugation processes. FCNs formed via the dehydration of hyaluronic acid, which were obtained by carbonizing HA, and partially carbonized HA fluorescence carbon nanoparticles (HA-FCNs), formed by a lower degree of carbonization, show good aqueous solubility, small particle size (<20 nm) and different fluorescence intensities with a red shift. After confirming the cytotoxicity of HA-FCNs and FCNs, we carried out in vitro and in vivo bioimaging studies where HA-FCNs themselves functioned as single particle triggers in target imaging. The converted nanocrystal carbon particles from HA provide outstanding features for in vitro and in vivo new targeted delivery and diagnostic tools.</P>
Sharker, Shazid Md.,Kim, Sung Min,Kim, Sung Han,In, Insik,Lee, Haeshin,Park, Sung Young The Royal Society of Chemistry 2015 Journal of Materials Chemistry B Vol.3 No.28
<P>The development of cooperative drug delivery systems that can detect and target the disease site, with rapid trigger controlled drug release (internally and externally), is widely expected to change the landscape of future drug carriers. In this study a drug delivery system was developed for the cancer-targeted release of chemotherapeutic agents inside living cells. This system is an environment sensitive (pH), and external photothermally remote controlled, cooperative image-guided drug delivery matrix. Partially carbonized fluorescence hyaluronic acid (HA-FCN) was conjugated with boronic acid (BA) to promote the formation of boronate ester with diol groups of β-cyclodextrin (CD) [HA-FCN-CD]. The pH influence mediated release of paclitaxel (PTX) from the CD cavity of HA-FCN-CD was utilized for targeted cancer bioimaging. This active-target delivery system (HA-FCN-CD-PTX) was found to show optical absorption properties similar to those of the near infrared (NIR) light sensitive carbonized material. This system exploits acidity for triggered drug release and rapid generation of mild photothermal heat to trigger burst release of PTX. Cooperative guided bioimaging that employs both internal pH responsive and external NIR controlled drug carriers is a promising method for chemotherapeutic release that can be adjusted according to physiological needs.</P>
Sharker, Shazid Md,Jeong, Chan Jin,Kim, Sung Min,Lee, Jung-Eun,Jeong, Ji Hoon,In, Insik,Lee, Haeshin,Park, Sung Young Wiley-VCH 2014 Chemistry - An Asian Journal Vol.9 No.10
<P>We report a stimuli-responsive fluorescent nanomaterial, based on graphene oxide coupled with a polymer conjugated with photochromic spiropyran (SP) dye and hydrophobic boron dipyrromethane (BODIPY) dye, for application in triggered target multicolor bioimaging. Graphene oxide (GO) was reduced by catechol-conjugated polymers under mildly alkaline conditions, which enabled to formation of functionalized multicolor graphene nanoparticles that can be induced by irradiation with UV light and by changing the pH from acidic to neutral. Investigation of these nanoparticles by using AFM, fluorescence emission, and in vitro cell and in vivo imaging revealed that they show different tunable colors in bioimaging applications and, more specifically, in cancer-cell detection. The stability, biocompatibility, and quenching efficacy of this nanocomposite open a different perspective for cell imaging in different independent colors, sequentially and simultaneously.</P>
( Shazid Md. Sharker ),김성민,이해신,박성영 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
We report a pH-dependent, NIR-sensitive, reduced graphene oxide (rGO) hybrid nano-composite synthesize via electrostatic interaction with indocyanine green (ICG) which is designed not only to destroy localized cancer cells but also be minimally invasive to surrounding normal cells. From pH 5.0 to 7.4, the near-infrared (NIR) irradiated hybrid nano-composites showed pH dependent photo-thermal heat generation capability, due to the pH response relief and quenching effects of poly(2-dimethyl amino ethyl methacrylate) [poly(PDMAEMA)] with ICG on a single rGO sheets. The in vitro cellular uptake and local NIR irradiated in vivo tumor ablation after 18 days treatment are very promising to fight against cancer.
( Shazid Md. Sharker ),이해신,박성영 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
Biodegradable polydioxanone (PDO) stents were coated with hyaluronic acid-dopamine (HA-DA) and barium sulfate (BaSO4) to enhance biocompatibility, tissue adhesiveness and radio-opacity for the treatment of esophageal diseases. The HA-DA conjugate was synt
Cancer targeted fluorescent carbon nanoparticle derived from hyaluronic acid
( Shazid Md. Sharker ),이해신,박성영 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.1
Targeted biocompatible bio-imaging carrier has the potential to revolutionized cancer diagnosis and therapy. To address these potentialities, we report one-step synthesis of hyaluronic acid fluorescent carbon nanoparticle (HA-FCN) and fluorescent carbon nanoparticle (FCN) obtain from the controlled carbonization method using the biocompatible hyaluronic acid (HA). The FCN with remaining HA (HA-FCN) and without identification of remaining HA (FCN) both showed aqueous solubility and small particle size (<20 nm) with different in fluorescence intensity. As a single particle, HA-FCN itself appeared for the first time to trigger targeted imaging for the probe. These findings speculate outstanding features for generating new target delivery and diagnostic tools.
Surface functionalization via catechol conjugated polymer coated substrate
( Shazid Md. Sharker ),정찬진,이해신,박성영 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
We report an effective surface polymerization and functionalization method by using catechol (CCDP) grafted poly[(2-hydroxyethyl methacrylate)-co-(2-(dimethylamino)ethyl methacrylate)] [poly(HEMA-co-DMAEAM)-g-CCDP, CGPH] composite. The functionalization have carried out via radical polymerization of N-isopropylacrylamide (NIPAAm) and ring opening polymerization (ROP) of carprolactone in a hydroxyl functional group of HEMA on a adhered substrate. Inspired by the adhesive properties of catechol, the silver nanoparticle (AgNPs) deposited on the substrate have performed significant antimicrobial effect. Interactions with both surface and inorganic AgNPs prompted catechol as a convenient surface modification tools.
강은비,Shazid Md. Sharker,인인식,박성영 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.43 No.-
Fluorescent carbon nanoparticles based target drug delivery with bio-imaging systems offer tremendousscope for future. We described Pluronic mimickingfluorescent nanoparticles (Plu-FNPs) surfacedecorated doxorubicin (DOX) via acid-cleavable hydrazone linkages with tumor target folic acid (FA)[Plu-FNPs-FA-DOX]. The acid labile of hydrazine linkage to DOX can easily break off by controlled pHinducing release of conjugated DOX at site of over-expressed folate receptors (FR). This nanoparticlesystem can deliver DOX to the target FR and trace the delivery pathway of cancer cells. The approachingplatform demonstrates the selectivity and sensitivity of molecular targets, thereby able to maximize thetherapeutic efficiency.
Jeong, Chan Jin,Sharker, Shazid Md.,In, Insik,Park, Sung Young American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.18
<P>Growing microbial resistance that renders antibiotic treatment vulnerable has emerged, attracting a great deal of interest in the need to develop alternative antimicrobial treatments. To contribute to this effort, we report magnetic iron oxide (Fe<SUB>3</SUB>O<SUB>4</SUB>) nanoparticles (NPs) coated with catechol-conjugated poly(vinylpyrrolidone) sulfobetaines (C-PVPS). This negatively charged Fe<SUB>3</SUB>O<SUB>4</SUB>@C-PVPS is subsequently encapsulated by poly(3,4-ethylenedioxythiophene) (PEDOT) following a layer-by-layer (LBL) self-assembly method. The obtained Fe<SUB>3</SUB>O<SUB>4</SUB>@C-PVPS:PEDOT nanoparticles appear to be novel NIR-irradiated photothermal agents that can achieve effective bacterial killing and are reusable after isolation of the used particles using external magnetic fields. The recyclable Fe<SUB>3</SUB>O<SUB>4</SUB>@C-PVPS:PEDOT NPs exhibit a high efficiency in converting photothermal heat for rapid antibacterial effects against <I>Staphylococcus aureus</I> and <I>Escherichia coli</I>. In this study, antibacterial tests for repeated uses maintained almost 100% antibacterial efficiency during three cycles and provided rapid and effective killing of 99% Gram-positive and -negative bacteria within 5 min of near-infrared (NIR) light exposure. The core–shell nanoparticles (Fe<SUB>3</SUB>O<SUB>4</SUB>@C-PVPS:PEDOT) exhibit the required stability, and their paramagnetic nature means that they rapidly convert photothermal heat sufficient for use as NIR-irradiated antibacterial photothermal sterilizing agents.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2015/aamick.2015.7.issue-18/acsami.5b02737/production/images/medium/am-2015-027375_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am5b02737'>ACS Electronic Supporting Info</A></P>