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Fault diagnosis method of rolling bearing based on deep belief network
Zhiwu Shang,Xiangxiang Liao,Rui Geng,Maosheng Gao,Xia Liu 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.11
A method based on the theory of deep learning and feature extraction and a fault diagnosis model of a rolling bearing based on deep belief network are proposed in this study considering the complex, nonlinear, and non-stationary vibration signal of the rolling bearing. To some extent, the method avoids the complex structure of deep neural network and can be easily trained. Experimental results show that the recognition rate of the method reaches 100 %. The method can identify various types of faults accurately and has good fault diagnosis capability, which can provide the convenience for maintenance.
Peng Liao,Shi-Qin Hu,Hong Zhang,Liang-Bi Xu,Jing-Zi Liu,Bin He,Shang-Gao Liao,Yong-Jun Li 대한화학회 2018 Bulletin of the Korean Chemical Society Vol.39 No.3
In our previous studies, we have shown that thiourea compounds containing phosphate esters have potent antitumor activity and can be used as a novel strategy for the development of antitumor agents. Herein, a series of novel phosphonate thioureas 5–38 have been synthesized, which were fully characterized by 1H NMR, 13C NMR spectrum, elemental analysis. Three human cancer cell lines (Bcap-37, BGC-823, and PC-3) have been used to investigate these compounds’ antitumor activities. After the summarization of the structure–activity relationships, we found that the variation of R, R1, and R2 in these novel phosphonate thioureas contribute to the antitumor activities. All these SAR-guided efforts may lead to novel antitumor drugs in the market in the near future.
Synthesis, Antibacterial Activity, and Structure–Activity Relationship of Fusaric Acid Analogs
Qing-Yan Zhang,Yang Fei‐Yu,Liao Shang‐Gao,Wang Bing,Li Rui,Dong Yong‐Xi,Zhou Meng,Yang Yuan‐Yong,Xu Guo‐Bo 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.4
Forty-one fusaric acid analogs possessing a pyridine carboxylic acid scaffold have been synthesized. The antibacterial activity results demonstrated that compounds 5b, 7b, 8c, and 8d displayed strong antibacterial activities against Staphylococcus aureus ATCC25923 with minimum inhibitory concentrations (MICs) of 4–16 μg/mL. Molecular docking study indicated that these compounds have strong hydrogen-bonding interactions with TyrRS. Meanwhile, 8c and 8d showed promising antibacterial activities against Pseudomonas aeruginosa ATCC9027. Compound 4 exhibited pronounced antibacterial activities against a clinically isolated multidrug-resistant strain of Escherichia coli (MIC: 64 μg/mL as compared 64 μg/mL of levofloxacin and 1024 μg/mL of ceftriaxone sodium). Moreover, compound 17e displayed strong synergistic antibacterial effect with levofloxacin against the multidrug-resistant strain, decreasing the MIC value of levofloxacin to 1/16 of its original MIC. No obvious cytotoxic activities against LO2 was observed for compounds 4, 5b, 8c, 8d, 17d, and 17e at 50 μM. The preliminary structure–activity relationship of fusaric acid analogs was also discussed.