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- 저자 : Shakeel Mahmood (검색결과 3 건)
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Shakeel Mahmood 대한공간정보학회 2022 Spatial Information Research Vol.30 No.4
Globally, COVID-19 is a top level public health concern. This paper is an attempt to identify and assess COVID-19 incidence hotspots in Metropolitan area of Pakistan using geo-statistical approach. The study is based on secondary data. The COVID-19 confirmed cases record (15/03/2020 to 15/04/2020) of entire Metropolitan area is obtained from hospitals and National Institute of Health website. Point-level geo-coding technique was applied on patient’s record and the relative location was converted into absolute location. Getis-Ord Gi* statistical model was applied in ArcGIS 10.3 to calculate Z-score and P values for each point location representing the COVID-19 incidence intensity. Then inverse distance weighted technique of spatial interpolation was applied on Z-score and spatial clusters of crime were geo-visualized in the form hotspot and cold spot. Spatially, more than 50% of land area of Allama Iqbal, Samanabad, Gulburg and Cantonment is covered by very high incidence zone which is surrounded by high incidence zone whereas Ravi, Shalimar, and north of Wagha and Aziz Bhatti towns are located in very low incidence zone. This study provides a suitable methodological framework for identification and analysis infectious disease hotspots. The study can also facilitate health and related authorities to fight war against COVID-19. Similarly, it can help policy makers to manage the movement of travelers and restrict social interaction.
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Association of SYK Genetic Variations with Breast Cancer Pathogenesis
Shakeel, Shafaq,Mahjabeen, Ishrat,Kayani, Mahmood Akhtar,Faryal, Rani Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Spleen tyrosine kinase (SYK) is a non-receptor type cytoplasmic protein and a known tumor suppressor gene in breast cancer. Polymorphisms in SYK have been reported to be associated with cell invasion/cell morality and an increased risk of cancer development. In this case control study, all exons of the SYK gene and its exon/ intron boundaries were amplified in 200 breast cancer cases and 100 matched controls and then analyzed by single stranded conformational polymorphism. Amplified products showing altered mobility patterns were sequenced and analyzed. Twelve variations were identified in exonic and intronic regions of DNA encoding SH2 domain and kinase domain of the SYK gene. All of these mutations are novel. Among them, 5 missense mutations were observed in exon 15 while one missense mutation was found in exon 8. In addition to these mutations, six mutations were also identified in intronic regions. We found a significant association between SYK mutations and breast cancer and observed that Glu241Arg, a missense mutation is associated with an increase risk of ~7 fold (OR=6.7, 95% CI=1.54-28.8), Thr581Pro (missense mutation) is associated with increased risk of ~16 fold (OR=15.5, 95%CI=2.07-115.45) and 63367 T>G (missense mutation) is associated with increased risk of ~13 fold (OR=12.8, 95%CI=1.71-96.71) for breast cancer. Significant associations were observed for each of these variations with both late menopause (p<0.01) and early menarche (p<0.005) cases when compared to controls. Our findings suggest that the polymorphic gene SYK may contribute to the development of breast cancer in at least the Pakistani population. This study provides an insight view of SYK which may provide a significant finding for the pharmaceutical and biotechnology industry.
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