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( Vikas Gupta ),( Manish Bhandare ),( Vikram Chaudhari ),( Shailesh Shrikhande ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Pretherapy serum neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio have been shown to predict prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). The aim of this study was to evaluate whether NLR, PLR and LMR help in predicting survival outcomes in patients with PDAC treated with curative intent surgery and chemotherapy at our center. Methods: A retrospective analysis was done of all operated cases of PDAC who underwent curative resection between 2011 to 2018. The pretherapy NLR, PLR and LMR were calculated and analyzed with respect to pathological and survival outcomes Results: 134 operated patients of PDAC were included in the analysis. 94 patients were operated upfront and 40 following neoadjuvant chemotherapy. The median overall survival and disease free survival was 24 months and 17 months respectively. The 1 and 2-year survival was 77.2% and 48% respectively. The Overall survival for NLR values of less than 2, 2.7 and 5 was 27, 25 and 25 months and for NLR more than 2, 2.7 and 5 was 22, 18 and 17 months respectively and was statistically insignificant . Similarly, the PLR and LMR were not significant for a cut off of 150 and 2.8 respectively. On univariate analysis only stage of disease was found to have significant correlation with survival Conclusions: The NLR, PLR and LMR do not correlate with survival in patients with pancreatic ductal adenocarcinomas in this study.
Gastric salvage after venous congestion during major pancreatic resections: A series of three cases
Ravi Chandra Reddy,Vikram Chaudhari,Amit Chopde,Abhishek Mitra,Dushyant Jaiswal,Shailesh V. Shrikhande,Manish S. Bhandare 한국간담췌외과학회 2024 Annals of hepato-biliary-pancreatic surgery Vol.28 No.1
Pancreatic resections, depending on the location of the tumor, usually require division of the vasculature of either the distal or proximal part of the stomach. In certain situations, such as total pancreatectomy and/or with splenic vein occlusion, viability of the stomach may be threatened due to inadequate venous drainage. We discuss three cases of complex pancreatic surgeries performed for carcinoma of the pancreas at a tertiary care center in India, wherein the stomach was salvaged by reimplanting the veins in two patients and preserving the only draining collateral in one case after the gastric venous drainage was compromised. The perioperative and postoperative course in these patients and the complications were analyzed. None of these 3 patients developed any complication related to gastric venous congestion, and additional gastrectomy was avoided in all these patients. Re-establishment of the Gastric venous outflow after extensive pancreatic resections helps to avoid additional gastric resection secondary to venous congestive changes.
Vikas Ostwal,Arvind Sahu,Anant Ramaswamy,Bhawna Sirohi,Subhadeep Bose,Vikas Talreja,Mahesh Goel,Shraddha Patkar,Ashwin Desouza,Shailesh V. Shrikhande 대한위암학회 2017 Journal of gastric cancer Vol.17 No.1
EOX chemotherapy with curative resection and D2 lymphadenectomy is a suggested alternative to the existing perioperative regimens. The acceptable postoperative complication rate and relatively high resections, chemotherapy completion, and survival rates obtained in this study require further evaluation and validation in a clinical trial.