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New Mathematical Stress Analysis in the Compressive Stage of the High-Pressure Torsion Process
S. Hadi,F. Rahimzadeh lotfabad,M. H. Paydar,R. Ebrahimi 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.8
In this study, a mathematical analysis based on the slab method is used to drive a formula to calculate the average hydrostaticpressure in the compressive stage of the HPT process. The analytical method used here leads to a relationship for describingthe average hydrostatic pressure as a function of the material shear strength, sample volume, cavity volume and force. Basedon the results obtained and by employing the Sturm’s theorem for polynomials, a general expression for the minimum forcerequired to start the deformation of the material under compressive force and creation of flash is developed. The analyticalresults were confirmed by carrying out some experiments by using commercial pure aluminum and copper as test materials. The experimental results showed good congruence with the analytical calculations. The most important outcome of thisanalysis is that with an appropriate selection of the sample volume, considering the capacity of the HPT press facility andthe proper choice of the die cavity volume, favorable average hydrostatic pressure, necessary for the purpose of applicationcan be achieved.
Intrauterine diabetic milieu instigates dysregulated adipocytokines production in F1 offspring
( Shady H. Tawfik ),( Maha M. Haiba ),( Mohamed I. Saad ),( Taha M. Abdelkhalek ),( Mervat Y. Hanafi ),( Maher A. Kamel ) 한국동물자원과학회(구 한국축산학회) 2017 한국축산학회지 Vol.59 No.1
Background: Intrauterine environment plays a pivotal role in the origin of fatal diseases such as the metabolic syndrome. Diabetes is associated with low-grade inflammatory state and dysregulated adipokines production. The aim of this study is to investigate the effect of maternal diabetes on adipocytokines (adiponectin, leptin and TNF-α) production in F1 offspring in rats. Methods: The offspring groups were as follows: F1 offspring of control mothers under control diet (CD) (CF1-CD), F1 offspring of control mothers under high caloric diet (HCD) (CF1-HCD), F1 offspring of diabetic mothers under CD (DF1-CD), and F1 offspring of diabetic mothers under HCD (DF1-HCD). Every 5 weeks post-natal, 10 pups of each subgroup were culled to obtain blood samples for biochemical analysis. Results: The results indicate that DF1-CD and DF1-HCD groups exhibited hyperinsulinemia, dyslipidemia, insulin resistance and impaired glucose homeostasis compared to CF1-CD (p > 0.05). DF1-CD and DF1-HCD groups had high hepatic and muscular depositions of TGs. The significant elevated NEFA level only appeared in offspring of diabetic mothers that was fed HCD. DF1-CD and DF1-HCD groups demonstrated low serum levels of adiponectin, high levels of leptin, and elevated levels of TNF-α compared to CF1-CD (p > 0.05). These results reveal the disturbed metabolic lipid profile of offspring of diabetic mothers and could guide further characterization of the mechanisms involved. Conclusion: Dysregulated adipocytokines production could be a possible mechanism for the transgenerational transmittance of diabetes, especially following a postnatal diabetogenic environment. Moreover, the exacerbating effects of postnatal HCD on NEFA in rats might be prone to adipcytokine dysregulation. Furthermore, dysregulation of serum adipokines is a prevalent consequence of maternal diabetes and could guide further investigations to predict the development of metabolic disturbances.
SHADI IBRAHIM KHALAF,Veena Mathad,SULTAN SENAN MAHDE,Ismail Naci CANGUL 장전수학회 2022 Proceedings of the Jangjeon mathematical society Vol.25 No.2
For a graph G having at least one edge, the minimum number of edges which we can remove from G such that the re- sulting graph has hub number larger than the hub number of G is called the pivot number p(G) of G. The values of pivot number for several classes of graphs are computed, and we determine the pivot number of join and corona products. Also some bounds for this parameter are obtained.
Global Trends in Plant Genomics Research to Improve Crop Productivity at PAG XXIV Conference
( Shadi Rahimi ),( Kwon Kyoo Kang ),( Yong Gu Cho1 ) 한국육종학회 2016 Plant Breeding and Biotechnology Vol.4 No.1
Increasing demand for food commodities and energy supply highlight the necessity to further improve crop productivity. At the Plant and Animal Genome Conference (PAG XXIV), recent developments and future plans for genomics research of plants and animals were presented. PAG XXIV provided a forum to explore crop genomes with the aim of providing new opportunities for crop breeding and the foundation for functional genomic studies to improve agriculture production and help feed the growing population. Genetic diversity and population structure studies of crops have allowed us to explore alleles related to different characteristics important for plant breeding. Several useful databases were introduced in PAG XXIV. They were developed to integrate a growing set of commonly used data types and analysis tools with new capabilities for visualization, exploration, and predictive analysis. This review highlights the global trends in plant genomics presented at PAG XXIV by focusing on crop productivity.
Emerging Challenges and Roles for Quantity Surveyors in the Construction Industry
Shadi Shayan,Ki Pyung Kim,Tony Ma,Rob Freda,Zhuoran Liu KINFORMS 2019 Management Review Vol.14 No.1
The current ever-changing environment of the construction industry demands Quantity Surveyors to update their knowledge and skills to cope with the changes. In order to provide insights for Quantity Surveyors to be able to manage a construction project productively and increase their ability in accordance with the current demand of the construction industry, this research conduct a questionnaire survey and interviews. As a result, the most critical challenges for Quantity Surveyors are a) Adopting new technologies such as BIM for their current practice, and b) Increasing their knowledge regarding sustainable attributes for a construction project. This research also disclosed that the expected emerging roles for Quantity Surveyors are a) Sustainable Advisory ability, and b) BIM ability for cost management. The research findings are expected to advise the current Quantity Surveyor and Quantity Surveying companies to prepare future competencies in accordance with the global trend.
Shadi Alghaffari,Muzamal Hussain,Mohamed A. Khadimallah,Faisal Al Thobiani,Hussain Talat Sulaimani Techno-Press 2023 Advances in nano research Vol.14 No.4
In this study, the bifurcation analysis of functionally graded material is done using exponential volume fraction law. Shell theory of Love is used for vibration of shell. The Galerkin's method is applied for the formation of three equations in eigen value form. This eigen form gives the frequencies using the computer software MATLAB. The variations of natural frequencies (Hz) for Type-I and Type-II functionally graded cylindrical shells are plotted for exponential volume fraction law. The behavior of exponent of volume fraction law is seen for three different values. Moreover, the frequency variations of Type-I and -II clamped simply supported FG cylindrical shell with different positions of ring supports against the circumferential wave number are investigated. The procedure adopted here enables to study vibration for any boundary condition but for brevity, numerical results for a cylindrical shell with clamped simply supported edge condition are obtained and their analysis with regard various physical parameters is done.
( Shadi S Yarandi ),( Daniel A Peterson ),( Glen J Treisman ),( Timothy H Moran ),( Pankaj J Pasricha ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2016 Journal of Neurogastroenterology and Motility (JNM Vol.22 No.2
Gut microbiome is an integral part of the Gut-Brain axis. It is becoming increasingly recognized that the presence of a healthy and diverse gut microbiota is important to normal cognitive and emotional processing. It was known that altered emotional state and chronic stress can change the composition of gut microbiome, but it is becoming more evident that interaction between gut microbiome and central nervous system is bidirectional. Alteration in the composition of the gut microbiome can potentially lead to increased intestinal permeability and impair the function of the intestinal barrier. Subsequently, neuro-active compounds and metabolites can gain access to the areas within the central nervous system that regulate cognition and emotional responses. Deregulated inflammatory response, promoted by harmful microbiota, can activate the vagal system and impact neuropsychological functions. Some bacteria can produce peptides or short chain fatty acids that can affect gene expression and inflammation within the central nervous system. In this review, we summarize the evidence supporting the role of gut microbiota in modulating neuropsychological functions of the central nervous system and exploring the potential underlying mechanisms. (J Neurogastroenterol Motil 2016;22:201-212)
Shadi Baniasadi,Arthit Chairoungdua,Yuji Iribe,Yoshikatsu Kanai,Hitoshi Endou,Ken-ichi Aisaki,Katsuhide Igarashi,Jun Kanno 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4
Inhibition of LAT1 (L-type amino acid transporter 1) activity in tumor cells could be effective in the inhibition of tumor cell growth by depriving tumor cells of essential amino acids. Because of the high level of expression of LAT1 in tumor cells, LAT1 inhibitors would be useful for anticancer therapy in suppressing tumor growth without affecting normal tissues. In recent years, cDNA microarray technique is useful technology for anticancer drug development. It allows identifying and characterizing new targets for developments in cancer drug therapy through the understanding genes involved in drug action. The present study was designed to investigate gene expression profile induced by LAT1 inhibitor using gene chip technology. Human bladder carcinoma cells (T24 cells) were treated with classical system L inhibitor 2-aminobicyclo-(2, 2, 1)-heptane-2-carboxylic acid (BCH). Gene chip experiment was applied for treated and untreated cells after 3 and 12 h. Two independent experiments with a high degree of concordance identified the altered expression of 151 and 200 genes after 3 and 12 h BCH treatment. Among these genes, 132 and 13 were up-regulated and 19 and 187 were down-regulated by 3 and 12 h BCH treatment respectively. We found that BCH affected the expression of a large number of genes that are related to the control of cell survival and physiologic behaviors. These data are useful for understanding of intracellular signaling of cell growth inhibition induced by LAT1 inhibitors as candidate for anticancer drug therapy.
Shadi Zolfagharian,Payam Zahedi,Mehdi Shafiee Ardestani,Alireza Khatibi,Saeed Jafarkhani 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-
This work was aimed to synthesize 5-fluorouracil (5-FU)-loaded sodium alginate (SA)/xanthan gum (Xan)hydrogels containing sulfuric acid-treated halloysite nanotube (tHNT) using free radical polymerizationand evaluate their apoptosis against HeLa cells in cervical cancer therapy. The nanocomposite hydrogelincluding tHNT (SA/Xan: tHNT, 1:1) showed a rough surface with cross-linking density of 171.9 10-4mol/cm3 compared to tHNT-free sample (62.5 10-4 mol/cm3). The 5-FU encapsulation efficiency ofthe samples in the presence and absence of tHNT was obtained approximately 60 % and 76 %, respectively. Moreover, the drug release of the samples with and without tHNT were measured 72 % and93 % in acidic medium as well as 32 % and 57 % in basic environment after 72 h. Finally, the cytotoxicityresults revealed the minimum cell viability (3.3 %) for tHNT-loaded hydrogel sample on the 4th day, andflow cytometry assessments also exhibited that the apoptosis rate of HeLa cells for this sample was85.4 %, resulting in its remarkable potential for destroying this cancerous cell line.