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Cystic Medullary Thyroid Carcinoma: A Case of Undergoing Endoscopic Thyroid Lobectomy
Dong Hae Chung,Jae Yeon Seok,Yoo Seung Chung1,Eun Mee Oh1,Jung Won Ryu1,Young Don Lee1 대한갑상선-내분비외과학회 2015 The Koreran journal of Endocrine Surgery Vol.15 No.1
On ultrasonography, medullary thyroid carcinoma (MTC) shows hypoechogenicity, an irregular margin, a predominantly solid composition, and microcalcifications, similar to those observed in papillary thyroid carcinoma (PTC). MTC presenting as a cystic lesion is rare, and endoscopic thyroidectomy can be performed for benign thyroid masses and early stage PTC, however it is inappropriate for MTC regardless of cystic change. The authors report a case of cystic MTC found after endoscopic thyroid lobectomy and provide a review of the literature on this topic.
Cav-1 (Caveolin-1) and Arterial Remodeling in Adult Moyamoya Disease
Chung, Jong-Won,Kim, Dong Hee,Oh, Mi Jeong,Cho, Yeon Hee,Kim, Eun Hee,Moon, Gyeong Joon,Ki, Chang-Seok,Cha, Jihoon,Kim, Keon Ha,Jeon, Pyoung,Yeon, Je Young,Kim, Gyeong-Moon,Kim, Jong-Soo,Hong, Seung C Ovid Technologies Wolters Kluwer -American Heart A 2018 Stroke Vol.49 No.11
<P>Conclusions Our findings suggest that cav-1 may play a major role in negative arterial remodeling in MMD.</P>
Topomer-CoMFA Study of Tricyclic Azepine Derivatives-EGFR Inhibitors
Chung, Jae-Yoon,Pasha, F.A.,Chung, Hwan-Won,Yang, Beom-Seok,Lee, Cheol-Ju,Oh, Jung-Soo,Moon, Myoung-Woon,Cho, Seung-Joo,Cho, Art E. The Korean Society of Toxicogenomics and Toxicopro 2008 Molecular & cellular toxicology Vol.4 No.1
EGFR has been intensively investigated as a target to block the signal transduction pathway which stimulates cancer growth and metastasis. Studies about structure-activity relationship for tricyclic azepine derivatives were performed with topomer-CoMFA. The derived topomer-CoMFA model with steric and electrostatic field parameters based on fragment units gave reasonable statistics ($q^2$=0.561, $r^2$=0.679). The model explains why a halogen atom at the meta position of aniline is important to increases inhibitory activity. This comes from an electrostatically negative groups are favored near this region. The model also shows that there are sterically favored regions around methoxy group extended from oxazepine derivatives. The findings about steric and electrostatic effects can be utilized for designing new inhibitors.
Synthesis, Characterization, and Applications of Organic-Inorganic Hybrid Mesoporous Silica
Chung, Jin-Sung,Kim, Dong-Jun,Ahn, Wha-Seung,Ko, Joung-Ho,Cheong, Won-Jo 한국화학공학회 2004 Korean Journal of Chemical Engineering Vol.21 No.1
Organic-inorganic hybrid mesoporous materials composed of homogeneously distributed ethane group in a silica framework were prepared by using 1, 2 bis (trimethoxysilyl) ethane (BTEM) as a precursor and alkyltrime-thylammonium-chloride or-bromide surfactant as a structure directing agent with or without the presence of a swelling agent, mesitylene. Characterization of the materials was performed by XRD, TEM/SEM, ^(29)Si-/^(13)C-solid state NMR, and N_(2)-adsorption. Testing of the hybrid materials as a reversed phase HPLC column stationary phase after C 18 surface-functionalization demonstrated a promising result, which closely approaches the performance of a commercial product. Mn-salen complex tethering on the hybrid material produced a catalyst with somewhat enhanced performance in liquid phase etherification with tert-butyl hydroperoxide as oxidant.
Analysis of Quasi resonant Current-fed Two-inductor Boost Converter for PV-MIC
Seung-Won Park,Jae-Hyeng Kim,Jun-Gu Kim,Tae-Won Lee,Chung-Yuen Won 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
This paper proposed a new zero-voltage switching (ZVS) Two-Inductor boost converter. The conventional Two-Inductor boost converter has defect. When the switch is turned off, the high voltage spike is occurred in the switch by leakage inductance and switch parasitic capacitor. To solve this problem, the parallel resonant capacitor is added to the conventional Two-Inductor boost converter. Using quasi-resonant between parallel resonant capacitance and leakage inductance, the switches is operated soft switching. A reduction of transformer turn ratio is achieved by the voltage doubler rectifier.
Chung, Hyunwoo,Hong, Sung Ji,Choi, So Won,Koo, Ja Young,Kim, Mingi,Kim, Hyun-Je,Park, Seung Bum,Park, Chung-Gyu Elsevier 2019 Biochemical and biophysical research communication Vol.514 No.4
<P><B>Abstract</B></P> <P>Pancreatic islet transplantation has been known as the best cure for patients suffering from severe type 1 diabetes mellitus (T1DM). Despite meaningful advances in human allogeneic islet transplantation field, significant amounts of islet loss in early post-transplantation periods is still a big concern for clinicians. One of the major factors determining the fate of the islets is the danger-associated molecular patterns (DAMPs) secreted by activated immune cells or islets themselves under hypoxic stress. High mobility group box 1 (HMGB1) protein is one of the best characterized DAMP molecules associated with islets. HMGB1 is known to be passively released by transplanted murine islet cells after taking damages from cytokines, reactive oxygen species, and other DAMPS, and the released HMGB1 harms neighboring islet cells by interacting with receptors expressed on murine islets such as toll-like receptor 2 (TLR2) and TLR4, thereby forming a vicious cycle. Here, we show that a small molecule inhibitor inflachromene (ICM) was capable of blocking the secretion of HMGB1 from murine islet cells during the normoxic and hypoxic post-isolation period. Notably, the treatment of ICM during the islet isolation process resulted in decreased HMGB1 levels during the subsequent cell culture. ICM's <I>in vivo</I> efficacy was evaluated in murine syngeneic islet transplantation model, and it significantly reduced the serum and graft level of HMGB1. Ultimately, the intraperitoneal administration of ICM prevented the loss of marginal-mass islet grafts and reversed the diabetes in mice.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Isolated pancreatic islets secrete HMGB1 during normoxic and hypoxic incubation. </LI> <LI> Inflachromene blocks HMGB1 secretion from isolated pancreatic islets. </LI> <LI> Inflachromene lowers serum and graft HMGB1 levels in islet transplant recipients. </LI> <LI> HMGB1 blockade increased <I>in vitro</I> and <I>in vivo</I> viability of pancreatic islets. </LI> <LI> Inflachromene's mass-sparing effect cured diabetic mice with marginal-mass islets. </LI> </UL> </P>
Chung, Won-Gyun,Kim, Jin,Lee, Eun-Ju,Lee, Seung-Jong 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.6
본 연구의 목적은 클로로필린이 치주인대 세포 생활력에 미치는 영향을 평가하는데 있다. 치주인대 세포는 건강한 사람에서 발치한 소구치의 치주인대 조직으로부터 채취하여 배양하였다. 비교 기준을 설정하기 위하여, HBSS 내에서 37℃로 보관한 치주인대 세포수의 50%가 생존하는데 소요되는 시간을 MTT 분석법에 의해 측정하였다. 그 결과는 6시간이었다. HBSS에 클로로필린 10, 100, 500 nM이 각각 첨가된 3군의 실험 보존액과 F-medium, ViaSpan, Likorol 등 모두 6군의 실험 보존액을 96-well plate에 접종한 후, 치주인대 세포를 동일한 수로 분주하였다. 이를 6시간동안 보관한 후, 각 실험군 보존액에서의 세포 생활력을 MTT 분석법으로 측정하였다. 또한, HBSS와 F-medium 및 클로로필린 500 nM이 첨가된 HBSS군의 세포들에 대해 유식세포 계측을 시행하여 각각의 세포주기를 분석하였다. 실험 결과, 클로로필린 500 nM이 첨가된 HBSS에서 보관한 세포들이 가장 높은 생활력을 나타내었으며, 클로로필린이 첨가되지 않은 HBSS에 비해서 유의하게 양호한 세포 생활력 유지 능력을 보였다. 클로로필린으로 처치한 세포들은 클로로필린의 농도가 커짐에 따라 세포 생활력이 증가하는 양상을 나타내었다. 유식세포 계측 결과, HBSS와 F-medium 및 클로로필린 500nM이 첨가된 HBSS에서 보관한 세포의 77~80%가 G0-G1 단계의 세포 주기로 측정되어, 대부분의 세포들이 안정된 세포 대사 상태를 보이는 것으로 나타났다. 결론적으로, 클로로필린 처치는 치주인대 세포의 생활력 유지에 도움이 되는 것으로 사료된다.