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Inhibition of chitin sulfate on human low density lipoprotein (LDL) oxidation by macrophages
Ryu,Beung Ho,Yang,Seung Tak,Mun,Yeun Hee 한국생명과학회 2001 한국생명과학회 학술발표회 Vol.33 No.-
Growing evidence indicates that oxidized to low density lipoprotein(LDL) may promotes atherogenesis. Therfore, inhibition of LDL oxidation may impede this process. The effect of chitin sulfate on the susceptibility of human low density lipoprotein(LDL) to macrophages-induced oxidation was investigated by monitoring TBARS. Chitin sulfate inhibited LDL oxidation by macrophages in a dose dependent manner, with an IC_(50) value 30μM, as assessed by a thiobarbituric acid reactive substance (TBARS) assay. Chitin sulfate, at 20μM, almost completely inhibited the macrophage-induced increase in electrophoretic mobility of LDL. These observations suggest that chitin sulfate might be an effective in prevention of atherosclerosis.
Kim, Seung Cheol,Song, Yong Sang,Kim, Young-Tae,Kim, Young Tak,Ryu, Ki-Sung,Gunapalaiah, Bhavyashree,Bi, Dan,Bock, Hans L,Park, Jong-Sup Korean Society of Gynecologic Oncology and Colposc 2011 Journal of Gynecologic Oncology Vol.22 No.2
<P><B>Objective</B></P><P>The study assessed the immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted cervical cancer vaccine in healthy Korean women aged 15-25 years.</P><P><B>Methods</B></P><P>Phase IIIB, double-blind, randomised (2:1), multi-centre trial was conducted in Korea from June 2007 to March 2008. The study enrolled 225 women in the HPV (N=149) and placebo (N=76) groups who received three doses of HPV-16/18 AS04-adjuvanted vaccine or placebo (aluminium hydroxide) administered intramuscularly at 0, 1, and 6 months and were followed until one month post-dose 3. Serum samples were collected pre-vaccination and one month post-dose 3. Safety and reactogenicity data were collected throughout.</P><P><B>Results</B></P><P>In this trial, 208 women completed the study (141 in HPV group; 67 in placebo group). At month 7, all initially seronegative women had seroconverted for HPV-16 and HPV-18 antibodies with anti-HPV-16 and anti-HPV-18 geometric mean titres of 9,351.4 El.U/mL (95% CI, 8,145.5 to 10,735.8) and 4204.1 El.U/mL (95% CI, 3,626.5 to 4,873.6), respectively. Initially seropositive women showed similar increase in geometric mean titre levels. Compliance to the three dose vaccination course was 95.3% in HPV and 89.5% in placebo group. Solicited local (pain) and general (fatigue, myalgia or headache) symptoms were commonly reported in both groups. Three serious adverse events were reported (two in HPV group; one in placebo group), all unrelated to vaccination by the investigator; all recovered.</P><P><B>Conclusion</B></P><P>The HPV-16/18 AS04-adjuvanted vaccine was highly immunogenic with a clinically acceptable safety profile in Korean women. This study was in line with previous global studies in Europe, North America, and Brazil. (ClinicalTrials.gov number, NCT 00485732.)</P>
Local kallikrein–kinin system is involved in podocyte apoptosis under diabetic conditions
Kwak, Seung-Jae,Paeng, Jisun,Kim, Do Hee,Lee, Sun Ha,Nam, Bo-Young,Kang, Hye Young,Li, Jin Ji,Jung, Dong-Sub,Han, Seung Hyeok,Ryu, Dong-Ryeol,Park, Jung Tak,Chang, Tae Ik,Yoo, Tae-Hyun,Han, Dae Suk,Ka Springer-Verlag 2011 Apoptosis Vol.16 No.5
Radial-firing optical fiber tip containing conical-shaped air-pocket for biomedical applications.
Lee, Seung Ho,Ryu, Yong-Tak,Son, Dong Hoon,Jeong, Seongmook,Kim, Youngwoong,Ju, Seongmin,Kim, Bok Hyeon,Han, Won-Taek Optical Society of America 2015 Optics express Vol.23 No.16
<P>We report a novel radial-firing optical fiber tip containing a conical-shaped air-pocket fabricated by deforming a hollow optical fiber using electric arc-discharge process. The hollow optical fiber was fusion spliced with a conventional optical fiber, simultaneously deforming into the intagliated conical-shaped region along the longitudinal fiber-axis of the fiber due to the gradual collapse of the cavity of the hollow optical fiber. Then the distal-end of the hollow optical fiber was sealed by the additional arc-discharge in order to obstruct the inflow of an external bio-substance or liquid to the inner air surface during the surgical operations, resulting in the formation of encased air-pocket in the silica glass fiber. Due to the total internal reflection of the laser beam at the conical-shaped air surface, the laser beam (lambda = 632.8 nm) was deflected to the circumferential direction up to 87 degree with respect to the fiber-axis. (C) 2015 Optical Society of America</P>
( Han Jak Ryu ),( Yung Ly Kim ),( Kyoung Sook Park ),( Young Eun Kwon ),( Mi Jung Lee ),( Hyung Jung Oh ),( Jung Tak Park ),( Seung Hyeok Han ),( Tae Hyun Yoo ),( Shin Wook Kang ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Diastolic heart failure (HF) is associated with cardiovascular (CV) morbidity and mortality in the general population as well as patients with end-stage renal disease (ESRD). However, it is not clear whether diastolic HF per se is associated with poor CV outcome in this population. This study was aimed to elucidate the impact of isolated diastolic dysfunction with preserved systolic function on CV outcomes in incident dialysis patients. Methods: A total of 194 incident ESRD patients, who started dialysis between July 2008 and August 2012 and had normal left ventricular (LV) systolic function, were included. The independent prognostic values of echocardiographic parameters for CV events were ascertained by multivariate Cox proportional hazard regression analysis. Kaplan-Meier curves were also constructed, and between-group survival was compared. Results: During a mean follow-up duration of 27.2 months, CV events occurred in 57 patients (29.4%). Compared to the CV event-free group, LV mass index, the ratio of early mitral fi ow velocity (E) to early mitral annulus velocity (E`) (E/E`), left atrial volume index (LAVI), and right ventricular systolic pressure were signifi cantly higher in patients with CV events. In multivariate Cox proportional hazard analysis, severe diastolic dysfunction (E/E`>15) and severely enlarged LA volume (LAVI>32 mL/m2) were independent risk factors for CV events [E/E`>15: hazard ratio (HR)=5.40, 95% confi dence interval (CI)=2.73-10.70, P<0.001; LAVI>32 mL/m2: HR=5.56, 95% CI=2.28-13.59, P<0.001]. When patients were divided into four groups according to E/E` and LAVI, Kaplan-Meier analysis revealed that patients with both E/E`>15 and LAVI>32 mL/m2 had the worst CV outcomes (P<0.001). Conclusions: Diastolic dysfunction even with preserved LV systolic function was associated with poor CV outcomes in incident dialysis patients.
Delta Neutrophil Index is a Predictor of Disease Severity in Patients with Acute Pyelonephritis
( Geun Woo Ryu ),( Hyung Woo Kim ),( Seohyun Park ),( Sul A Lee ),( Jonghyun Jhee ),( Su-young Jung ),( Hyung Jung Oh ),( Jung Tak Park ),( Seung Hyeok Han ),( Shin-wook Kang ),( Tae-hyun Yoo ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: Delta neutrophil index (DNI) is the fraction of immature granulocytes provided by a complete blood count analyzer. Previous studies demonstrated that DNI is a novel marker to predict outcomes in sepsis patients. Therefore, this study aimed to evaluate DNI as a predictor of disease severity in patients with acute pyelonephritis (APN). Methods: Patients diagnosed with APN at Severance Hospital from December 2009 to July 2012 were retrospectively investigated. DNI levels were measured at the time of admission. The patients were classified into two groups according to the median value of DNI at baseline. Severe APN was diagnosed with one or more of these conditions including bacteremia, acute kidney injury, hypotension requiring use of vasopressors and admission of intensive care unit. Independent risk factors for severe APN were determined by multiple logistic regression analysis. Receiver operating characteristic (ROC) curves were plotted for DNI, white blood cell (WBC) count and C-reactive protein (CRP). Results: A total of 258 patients were included in this study. The median age was 61.0 (19.0-87.0), 237 patients (91.9%) were female, and the median DNI level was 2.5%. Severe APN was significantly more prevalent in high DNI group. Multivariate analysis showed that DNI, WBC count and CRP level independently predicted severe APN. DNIwas a better predictive marker of severe APN than WBC count, as reflectd by area under the ROC curve analysis (0.697 [95% CI, 0.637-0.753] vs. 0.562 [95% CI, 0.499-0.624], p=0.0013). DNI was not inferior to CRP levels to predict severe APN (0.697 [95% CI, 0.637-0.753] vs. 0.633 [95% CI, 0.571-0.692], p=0.1185). Conclusions: DNI level at admission is a valuable predictor of disease severity in patients with APN.