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Seung Jin Kwag,Kyu Hong Kim,Hyun Joon Kim,Sang Soo Kang,Gyeong Jae Cho,Wan Sung Choi,Gu Seob Roh 대한해부학회 2008 Anatomy & Cell Biology Vol.41 No.3
Seizure activity increases glucose utilization within the brain in response to neuronal injury. In this study, we investigated the expression of two brain glucose transporter (GLUT) proteins, GLUT1 and GLUT3, in the mouse hippocampus after kainic acid (KA) treatment. Forty-eight hours after KA (30 mg/kg) injection, mice were sacrificed and a histological evaluation of KA-treated hippocampus revealed cell death using cresyl violet staining and immunohistochemistry for caspase-3. In KA-treated hippocampus, reactive astrocytic changes were confirmed by increased immunoreactivity of glial fibrillary acidic protein (GFAP). Enhanced GLUT1-positive endothelial cells were present in the hippocampus after KA treatment. However, GLUT3-positive neurons were not localized to the KAtreated hippocampus. In particular, although GLUT-3 was not expressed in the hippocampus, pronounced GLUT3-positive cells were observed in the hypothalamic paraventricular nucleus (PVN), which controls energy metabolism. Thus, these results indicate that changes in endothelial GLUT1 and neuronal GLUT3 levels in response to neural injury may play important roles in neuroprotection against brain excitotoxicity.
Jin-Kwon Lee,Seung-Jun Lee,Young-Sool Hah,Yeong-Ho Ji,Young-Tae Ju,Young-Joon Lee,Chi-Young Jeong,Ju-Yeon Kim,Ji-Ho Park,Jae-Myung Kim,Jin-Kyu Cho,Han-Gil Kim*,Seung-Jin Kwag* 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.105 No.6
Purpose: This study aimed to investigate the potential role of copine-1 (CPNE1), a calcium-dependent membrane-binding protein encoded by the CPNE1 gene, in colorectal cancer (CRC). Despite previous research on the involvement of copine family members in various solid tumors, the specific role of CPNE1 in CRC remains poorly understood. Methods: We conducted clinicopathological analysis and functional studies to explore the impact of CPNE1 in human CRC. We examined the expression levels of CPNE1 in CRC patients and correlated it with invasive depth, lymph node metastasis, distant metastasis, lymphatic invasion, and TNM stage. Additionally, we performed experiments to assess the functional consequences of CPNE1 knockdown in CRC cells, including proliferation, colony formation, migration, invasion, and the expression of key regulators involved in the cell cycle and epithelial-mesenchymal transition (EMT). Furthermore, we evaluated the effects of CPNE1 knockdown on tumor growth using a xenograft mouse model. Results: High expression of CPNE1 was significantly associated with advanced tumor features in CRC patients. CPNE1 knockdown in CRC cells led to impaired abilities in proliferation, colony formation, migration, and invasion. Furthermore, CPNE1 silencing resulted in the suppression of protein expression related to the cell cycle and EMT. In the xenograft mouse model, CPNE1 knockdown inhibited tumor growth. Conclusion: CPNE1 plays a crucial role in promoting tumorigenesis and metastasis in human CRC. By regulating the cell cycle and EMT, CPNE1 influences critical cellular processes at the membrane-cytoplasm interface. These results provide valuable insights into the potential development of novel therapeutic strategies for CRC targeting CPNE1.
Adenocarcinoma arising from Meckel's diverticulum in the ileum with malrotation of the midgut
Jin Kwon Lee,Seung Jin Kwag,Seong Taek Oh,Jun Gi Kim,Won Kyung Kang 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.84 No.6
Meckel"s diverticulum (MD) is a true congenital diverticulum that is remnant by incomplete obliteration of the omphalomesenteric duct. It is the most common congenital anomaly of the gastrointestinal tract, with an estimated prevalence of 2% (0.3% to 3% in autopsy studies). About 90% of MD occurs within 100 cm of the ileocecal valve. A primary malignant tumor arising within an MD is extremely uncommon. Malignancies are reported to account for only 0.5% to 3.2% of the complications. Carcinoids are the most common malignant tumors occurring in MD. Adenocarcinomas are extremely uncommon and very poor prognosis has been reported. We report a case of radiographically diagnosed chronic inflammatory mass caused by adenocarcinoma arising from MD in the ileum with malrotation of the midgut incidentally discovered at exploration.
Seung-Jin Kwag,Jun-Gi Kim,Won-Kyung Kang,Jin-Kwon Lee,Seong-Taek Oh 대한외과학회 2014 Annals of Surgical Treatment and Research(ASRT) Vol.86 No.4
Purpose: The authors evaluate the prevalence of malnutrition and its effect on the postoperative morbidity of patients after surgery for colorectal cancer. Methods: Three hundred fifty-two patients were enrolled prospectively. Nutritional risk screening 2002 (NRS 2002) score was calculated through interview with patient on admission. Clinical characteristics, tumor status and surgical procedure were recorded. Results: The prevalence of patients at nutritional risk was 28.1 per cent according to the NRS 2002. The rate of postoperative complication was 27%. There was a significant difference in postoperative complication rates between patients at nutritional risk and those not at risk (37.4% vs. 22.9%, P = 0.006). Nutritional risk was identified as an independent predictor of postoperative complications (odds ratio, 3.05; P = 0.045). Nutritional risk increased the rate of anastomotic leakage (P = 0.027) and wound infection (P = 0.01). Conclusion: NRS may be a prognostic factor for postoperative complication after surgery for colorectal cancer. A large scaled prospective study is needed to confirm whether supplementing nutritional deficits reduces postoperative complication rates.
젠더특성에 따라 조직문화가 동적역량을 매개로 조직유효성에 미치는 영향
곽효근 ( Kwag Hyo Keun ),서철승 ( Seo Cheol Seung ),이상진 ( Lee Sang Jin ) 한국경영공학회 2019 한국경영공학회지 Vol.24 No.1
Many companies attempt to transform themselves into creative organizations to create high performance. Organizational culture and dynamic capabilities are essential to make a creative organization. As the participation of women in society is more prevalent than ever, enterprises should have more concern on creating an environment that maximizes the capability of women as a way of improving the business performance. The purpose of this study is to verify the mediating effect of dynamic capabilities that affects creativity for the organizational culture to influence organizational effectiveness in a rapidly changing environment, the fourth Industrial Revolution. Furthermore, this research investigates differences in organizational culture and dynamic capabilities according to gender characteristics. The result of this research is as followings. Rational culture affected to organizational effectiveness, however, Hierarchical culture affected only to creativity as a sub-factor of organizational effectiveness. Absorptive transformation capabilities as a sub-factor of dynamic capabilities mediated organizational culture and organizational effectiveness. And absorptive transformation capabilities positively affected to the organizational effectiveness in hierarchical culture as well. Rational culture positively affected to both dynamic capabilities and organizational effectiveness regardless of gender. In the rational culture, women are more involved to their job than men, and their performance is more than twice as high. Hierarchical culture influenced men's dynamic capabilities, but did not affect women's dynamic capabilities. Thus, this study represents that enterprises should build rational culture to business performance by utilizing the competence of female workers and have more concern on making environment for employees to exercise their dynamic capabilities.