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함승희,서영주,정은미,채선희 효성여자대학교 문리과대학 학도호국단 1984 文理大論集 Vol.4 No.-
This study was carried out to get the basic date for effective control of apple canker disease in Daegu; Chilgog, Gyeongsan, and Weolseong, which were major appleproduction districts. The relationship among occurence rate of apple canker, district, infected side of trunk, and nutrition state of apple leaf were examined. The results of the study were summarized as follows. 1. The occurence rates of apple canker were a little high in Yeongcheon and Gyeongsan district as 81.7%, 83.5% respectively, but in Chilgog district was 70.2%. 2. The occurence rates were high in Spur Early Blaze, Spur Golden and Megumi varieties as 84.8%, 87.3%, 88.6% respectively, but in Rallss Genet, Moris delicious, Starkrimson, Raritan variety were tend to lower as 69.4%-72.3%. 3. The occurence rate of free stocked tree was high as 81.8%, But in dwarf stocked tree was low as 73.8%. 4. The occurence rate was 80.7% in trunk and main blanch part, and in the east and south side of trunk. The occurence rate of apple canker was 55.7%. 5. There was significant positive correlation(r=0.516^*)between occurence rate of apple canker and N content of apple leaf, but negative correlation (r=-0.589^*) in P_2O_5 content. 6. Occurence rate of apple canker was tend to higher as the ca/Mn ratio in apple leaf was lower.
Litsenolide A2: The major anti-inflammatory activity compound in <i>Litsea japonica</i> fruit
Ham, Young-Min,Cho, Su-Hyeon,Song, Sang-Mok,Yoon, Seon-A,Lee, Yong-Bum,Kim, Chang-Sook,Kwon, Seung-Hae,Jeong, Myeong Seon,Yoon, Weon-Jong,Kim, Kil-Nam Elsevier 2017 Journal of Functional Foods Vol.39 No.-
<P><B>Abstract</B></P> <P>In this study, we investigated the anti-inflammatory effect of litsenolide A2 (LNA2) isolated from <I>L. japonica</I> fruit and its mechanism of action in LPS-induced RAW 264.7 cells. LPS-induced production of anti-inflammatory mediators and cytokines such as NO, PGE<SUB>2</SUB>, iNOS, COX-2, TNF-α, and IL-6 was significantly inhibited by LNA2. Next, western blot experiments were performed to investigate the mechanism of action of the anti-inflammatory effect of LNA2. The results indicated that LNA2 markedly reduced the LPS-induced activation of NF-κB and the nuclear translocation of NF-κB p65. Furthermore, LNA2 also inhibited the phosphorylation of MAPK by LPS. LNA2 was the major component in the ethanol extract of <I>L. japonica</I> at 59 mg/g according to high performance liquid chromatography (HPLC). These results indicate that LNA2 can be used as a functional and marker compound for standardization of the manufacturing process when <I>L. japonica</I> fruit is used as a functional food.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We study the anti-inflammatory effect of LNA2 in LPS-activated RAW 264.7 cells. </LI> <LI> LNA2 inhibited production of pro-inflammatory mediator and cytokines. </LI> <LI> LNA2 exhibited anti-inflammatory properties by suppression of NF-κB and MPAKs. </LI> <LI> LNA2 was the major component in the ethanol extract of <I>L. japonica</I> at 59 mg/g. </LI> </UL> </P>
TP53 gain-of-function mutation promotes inflammation in glioblastoma
Ham, Seok Won,Jeon, Hee-Young,Jin, Xiong,Kim, Eun-Jung,Kim, Jun-Kyum,Shin, Yong Jae,Lee, Yeri,Kim, Se Hoon,Lee, Seon Yong,Seo, Sunyoung,Park, Min Gi,Kim, Hye-Mi,Nam, Do-Hyun,Kim, Hyunggee Nature Publishing Group 2019 Cell death and differentiation Vol.26 No.3
Seon-A Yoon,Young-Min Ham,Sang-Chul Han,Ho Bong Hyun,Boram Go,Yong-Hwan Jung,Eun-Sook Yoo,Weon-Jong Yoon 한국식품영양과학회 2023 Preventive Nutrition and Food Science Vol.28 No.3
In this study, immature persimmon (Diospyros kaki Thunb.) ethanol extract was administered to an obese animal model fed a high-fat diet to measure weight change, adipose tissue weight, serum lipid level, and expression level of adipose-related genes to evaluate its efficacy. Administration of D. kaki ethanol extract (DKE) (100 and 500 mg/kg/d) decreased the body weight gain, adipose tissue weight, and serum triglyceride levels in mice fed a high-fat diet. Furthermore, it improved the leptin and adiponectin levels in the blood as well as gene expression in the liver. It also inhibited the expression of sterol regulatory element-binding protein-1c, inhibiting the production of triglyceride biosynthetic enzyme fatty acid synthesis and acetyl-CoA carboxylase, and decreased the expressions of peroxisome proliferator-activated receptor and CCAAT/enhancer-binding proteins that induce adipocyte differentiation. Therefore, these data suggest that DKE exerts beneficial effects on high-fat diet-induced obesity by modulating lipid metabolism in mice fed a high-fat diet.