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Seol, Young Mi,Kwon, Bo Ran,Song, Moo Kon,Choi, Young Jin,Shin, Ho Jin,Chung, Joo Seop,Cho, Goon Jae,Lee, Jin Chun,Lee, Byung Joo,Wang, Soo Geun,Kim, Hak Jin,Kim, Won Taek,Kim, Seung Jang,Yun, Eun You Acta Oncologica 2010 Acta Oncologica Vol.49 No.2
<P>PURPOSE: To evaluate the prognostic value of the metabolic tumor volume measured on 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging and other clinical factors in patients treated for locally advanced head-and-neck cancer (HNC) at a single institution. MATERIALS AND METHODS: Between June 2005 and August 2008, 59 patients with HNC that underwent pretreatment FDG-PET studies received neoadjuvant chemotherapy and radiation therapy. Metabolically active tumor regions were delineated on the pretreatment PET scans by a fixed SUV of 2.5. We evaluated the relationship of the 18F-fluorodeoxyglucose-PET maximum standardized uptake value (SUV) and the metabolic tumor volume (MTV) with the progression-free survival (PFS) and overall survival (OS). RESULTS: The MTV and lymph node metastasis were predictive of the PFS and OS. The lymph node status did not correlate with the MTV. A higher MTV of 9.3 cm(3) was significantly associated with an increased risk of recurrence (2.19-fold, p = 0.006) and death (1.62-fold, p = 0.051). Separation of patients with tumor volumes <or= 9.3 cm(3) and no lymph node disease vs. any other combination was strongly predictive of the PFS and the OS. CONCLUSIONS: MTV and lymph node status were prognostic values associated with survival. Quantitative measurement of tumor volume separates patients with a good prognosis from those with a poorer prognosis. A subset of patients with relatively small tumors and no lymph node involvement did very well.</P>
Vasomotor Symptoms: More Than Temporary Menopausal Symptoms
( Ki-jin Ryu ),( Hyuntae Park ),( Jin Seol Park ),( Yeon Woo Lee ),( Soo Young Kim ),( Hayun Kim ),( Youngmi Jeong ),( Yong Jin Kim ),( Kyong Wook Yi ),( Jung Ho Shin ),( Jun Young Hur ),( Tak Kim ) 대한폐경학회 2020 대한폐경학회지 Vol.26 No.3
Vasomotor symptoms (VMS), such as hot flashes and night sweating, are classic menopausal symptoms experienced by a majority of perimenopausal and postmenopausal women. VMS have received a great deal of attention due to their relationship with cardiometabolic risk. Further, accumulating evidence indicates that VMS are associated with an increased risk of several chronic diseases, including metabolic syndrome, type 2 diabetes mellitus, nonalcoholic fatty liver diseases, and osteoporosis in perimenopausal and postmenopausal women. These findings suggest VMS as biomarkers of impaired cardiometabolic conditions rather than just temporary symptoms in menopausal women, warranting further studies to confirm the casual relationship of VMS with these diseases and the exact underlying mechanism in this context.
Genetic structure of Korea Brassica rapa core collection based on Mariner transposon display
Mina Jin,Young-Joo Seol,Mi-suk Seo,Seong-Han Sohn,Soo-Jin Kwon,Jeong-Hwan Mun,Guusje Bonnema,Beom-Seok Park 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
We have identified ATTIRTA1 transposon, a kind of mariner-type DNA transposon from Brassica rapa genome. A total of 811 inverted-terminal repeat, ITR consisting of the both terminal on ATTIRTA1 transposon were found from B. rapa v1.1 sequence. Among them 616 ITR were paired by two in each transposon, indicating three quarters of the transposon exists in original form. Around 10 percentage of the transposon, 82 ITR was located in gene, expecially only in intron. Using these ATTRRTA1, we developed a display system modified from AFLP technique and applied for this system to analyze genetic diversity of Korea Brassica rapa core collection. The collection includes 220 accessions representing the different morphotypes and geographical origin. The analysis of population structure revealed five subgroups and the clustering patterns matched well with their morphological traits. ATTIRTA1 transposon display seems useful marker system for studying genetic relationships. Presently we have profiled the components and contents of glucosinolate in the core collection to analyze genome wide association. This collection will be helpful to identify agriculturally desirable traits from other supspecies.