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( Youn Hee Cho ),( Bong Min Ko ),( Shin Hee Kim ),( Yu Sik Myung ),( Jong Hyo Choi ),( Jae Pil Han ),( Su Jin Hong ),( Seong Ran Jeon ),( Hyun Gun Kim ),( Jin Oh Kim ),( Moon Sung Lee ) 대한장연구학회 2014 Intestinal Research Vol.12 No.2
Background/Aims: Colorectal cancer (CRC) develops from colonic adenomas. Type 2 diabetes mellitus (DM) is associatedwith a higher risk of CRC and metformin decreases CRC risk. However, it is not certain if metformin affects the developmentof colorectal polyps and adenomas. This study aimed to elucidate if metforminaffects the incidence of colonic polyps and adenomasin patients with type 2 DM. Methods: Of 12,186 patients with type 2 DM, 3,775 underwent colonoscopy between May2001 and March 2013. This study enrolled 3,105 of these patients, and divided them in two groups: 912 patients with metforminuse and 2,193 patients without metformin use. Patient clinical characteristics, polyp and adenoma detection rate in the twogroups were analyzed retrospectively. Results: The Colorectal polyp detection rate was lower in the metformin group than inthe non-meformin group (39.4% vs. 62.4%, P <0.01). Colorectal adenoma detection rate was significantly lower in the metformingroup than in the non-metformin group (15.2% vs. 20.5%, P <0.01). Fewer advanced adenomas were detected in the metformingroup than in the non-metformin group (12.2% vs. 22%, P <0.01). Multivariate analysis identified age, sex, Body mass index andmetformin use as factors associated with polyp incidence, whereas only metforminwas independently associated with decreasedadenoma incidence (Odd ratio=0.738, 95% CI=0.554-0.983, P =0.03). Conclusions: In patients with type 2 DM, metforminreduced the incidence of adenomas that may transform into CRC. Therefore, metformin may be useful for the preventionof CRC in patients with type 2 DM. (Intest Res 2014;12:139-145)
Phase Transition Method To Form Group 6A Nanoparticles on Carbonaceous Templates
Youn, Hee-Chang,Jegal, Jong-Pil,Park, Sang-Hoon,Kim, Hyun-Kyung,Park, Ho Seok,Roh, Kwang Chul,Kim, Kwang-Bum American Chemical Society 2014 ACS NANO Vol.8 No.3
<P>Considerable effort has been made to develop unique methods of preparing and characterizing nanoparticles and nanocomposites in order to exploit the true potential of nanotechnology. We used a facile, versatile phase-transition method for forming Group 6A nanoparticles on carbonaceous templates to produce homogeneous 5–10 nm diameter Group 6A nanoparticles on carbon nanotubes (CNTs) and reduced graphene oxide (RGO), to obtain nanocomposites. The method involved melting and recrystallizing mixtures of elemental sulfur and either CNTs or RGO on carbonaceous templates. The surface tension and hydrophilicity of the molten Group 6A species surfaces and the oxygen functional groups on the carbonaceous template surfaces were considered in depth to provide important guidelines for forming Group 6A nanoparticles on carbonaceous templates. The surface tension of the molten Group 6A species should be intrinsically low, leading to effective wetting on the carbonaceous template. In addition, the molten Group 6A species hydrophilic surfaces were essential for enabling hydrophilic–hydrophilic interaction for selective wetting at the oxygen functional groups on the carbonaceous template, leading to the heterogeneous nucleation of nanoparticles. Furthermore, the size and morphology (isolated <I>vs</I> layer-like) of the Group 6A nanoparticles were tuned by adjusting the oxidation state of the carbonaceous template. We investigated the potential application of the nanocomposites prepared using this method to cathode materials in lithium–sulfur secondary batteries.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-3/nn405633p/production/images/medium/nn-2013-05633p_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn405633p'>ACS Electronic Supporting Info</A></P>
Sang-Hoon Kim,Jang Hyun Kim,YongHee Lee,Hyunseok Yang,Joo-Youn Park,Kyoung-Su Park,Young-Pil Park IEEE 2009 IEEE transactions on magnetics Vol.45 No.5
<P>Tilt error can affect a serious effect to holographic data storage system using angle(polytopic) multiplexing. Because the tolerance about tilt error is very tight it is important to measure the tilt error and compensate it. In this paper, tilt error measurement system with additional red laser and reflection geometry is suggested and servo control experiments are conducted. A servo controller to compensate tilt error is designed using disturbance observer. Amount of tilt is decreased smaller than 0.01 degree and signal-to-noise ratio is increased with the tilt servo controller when 0.216 degree of tilt disturbance is applied.</P>
Roles of unphosphorylated ISGF3 in HCV infection and interferon responsiveness
Sung, Pil Soo,Cheon, HyeonJoo,Cho, Chung Hwan,Hong, Seon-Hui,Park, Do Youn,Seo, Hyung-Il,Park, Su-Hyung,Yoon, Seung Kew,Stark, George R.,Shin, Eui-Cheol Proceedings of the National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.33
Radicicol Inhibits iNOS Expression in Cytokine-Stimulated Pancreatic Beta Cells
Youn, Cha Kyung,Park, Seon Joo,Li, Mei Hong,Lee, Min Young,Lee, Kun Yeong,Cha, Man Jin,Kim, Ok Hyeun,You, Ho Jin,Chang, In Youp,Yoon, Sang Pil,Jeon, Young Jin The Korean Society of Pharmacology 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.4
Here, we show that radicicol, a fungal antibiotic, resulted in marked inhibition of inducible nitric oxide synthase (iNOS) transcription by the pancreatic beta cell line MIN6N8a in response to cytokine mixture (CM: TNF-${\alpha}$, IFN-${\gamma}$, and IL-$1{\beta}$). Treatment of MIN6N8a cells with radicicol inhibited CM-stimulated activation of NF-${\kappa}B$/Rel, which plays a critical role in iNOS transcription, in a dose-related manner. Nitrite production in the presence of PD98059, a specific inhibitor of the extracellular signal-regulated protein kinase-1 and 2 (ERK1/2) pathway, was dramatically diminished, suggesting that the ERK1/2 pathway is involved in CM-induced iNOS expression. In contrast, SB203580, a specific inhibitor of p38, had no effect on nitrite generation. Collectively, this series of experiments indicates that radicicol inhibits iNOS gene expression by blocking ERK1/2 signaling. Due to the critical role that NO release plays in mediating destruction of pancreatic beta cells, the inhibitory effects of radicicol on iNOS expression suggest that radicicol may represent a useful anti-diabetic activity.