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Salunkhe, Rahul R.,Jang, Kihun,Lee, Sung-won,Yu, Seongil,Ahn, Heejoon The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.40
<P>Carbon nanotube and metal oxide/hydroxide hybrids have attracted much interest as electrode materials for electrochemical supercapacitors because of their dual storage mechanism. They can complement or replace batteries in electrical energy storage and harvesting applications, where high power delivery or uptake is needed. Multi-walled carbon nanotube (MWCNT) and nickel–cobalt binary metal hydroxide nanorod hybrids have been developed through the chemical synthesis of binary metal hydroxide on a MWCNT surface. These hybrids show enhanced supercapacitive performance and cycling ability. Growth of a thin film consisting of a coating of binary metal hydroxide, as well as further growth of nanorod structures, is demonstrated using FESEM and TEM, showing that this film is a promising structure for supercapacitor applications. These electrodes yield a significantly high capacitance of 502 F g<SUP>−1</SUP> with a high energy density of 69 W h kg<SUP>−1</SUP> at a scan rate of 5 mV s<SUP>−1</SUP>. The film is stable up to 5000 cycles with greater than 80% capacitance retention.</P> <P>Graphic Abstract</P><P>A novel composite material composed of cost effective pseudocapacitive nanostructures like Ni–Co hydroxide nanorods and CNT was fabricated on a stainless steel substrate and further utilized for supercapacitor applications. The electrodes yield a significantly high specific capacitance of ∼502 F g<SUP>−1</SUP> with an energy density of 69 W h kg<SUP>−1</SUP>. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm32638h'> </P>
Salunkhe, D.B.,Gargote, S.S.,Dubal, D.P.,Kim, W.B.,Sankapal, B.R. North Holland ; Elsevier Science Ltd 2012 Chemical physics letters Vol.554 No.-
A facile room temperature (27<SUP>o</SUP>C) chemical route, namely successive ionic layer adsorption and reaction (SILAR) method is used to deposit antimony trisulphide (Sb<SUB>2</SUB>S<SUB>3</SUB>) nanoparticles on mesoporous titanium dioxide (TiO<SUB>2</SUB>). The method facilitates linker free approach to deposit the size tuned nanoparticles. The synthesized TiO<SUB>2</SUB>/Sb<SUB>2</SUB>S<SUB>3</SUB> structure on a FTO (fluorine doped tin oxide coated glass substrate) was used as a photoanode with polysulphide as liquid electrolyte and platinum coated FTO as back contact to construct the photovoltaic device. The photovoltaic performances have been tested under light illumination with standard solar simulator condition (AM 1.5G, 10mW/cm<SUP>2</SUP>) and photovoltaic parameters are discussed.
Sachin S. Salunkhe,Neela M. Bhatia,Jyoti D. Thorat,Prafulla B. Choudhari,Manish S. Bhatia 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.4
The objective of this study was to optimizeibuprofen loaded nanoemulsion by using a factorial designapproach. In the present study attempts have been made toformulate and evaluate nanoemulsion for topical deliveryof ibuprofen. Solvent precipitation technique was used fordevelopment of ibuprofen nanoemulsion. Miglyol 840 wasscreened as the oil phase due to a good solubilisationcapacity (0.197 ± 0.012 g/mL) for ibuprofen. On the basisof RHLB of an oil phase Labrasol and Triton X 100 wereused as surfactant and cosurfactant, respectively. The studyinvestigated the utility of 23 factorial design for optimizationprocess of nanoemulsion batches. Present modeldemonstrated the significance of factors such as drugconcentration (X1), anti-solvent volume (X2) and surfactantcosurfactant combination concentration (X3) on particlesize (Y1) and encapsulation efficiency (Y2). Optimizednanoemulsion showed better flux value (Jss), skin permeationcoefficient (Kp) as compared to plain ibuprofen gel. Drug deposition study revealed that optimized ibuprofennanoemulsion showed deposition of 26.13 ± 3.47 lg cm-2in comparison to the deposition of 16.50 ± 2.34 lg cm-2shown by plain ibuprofen loaded gel. While the antiinflammatorystudy has shown faster onset of action withthe nanoemulsion which was confirmed by 75 ± 1.27 %inhibition of inflammation at the end of 1 h and63.97 ± 1.71 % at the end of 24 h. The effect of drug wasenhanced by prepared nanoemulsion formulation andhence confirms the utility of nanoemulsion system as avehicle for better topical delivery of ibuprofen.
Sachin S. Salunkhe,Neela M. Bhatia,Varsha B. Pokharkar,Jyoti D. Thorat,Manish S. Bhatia 한국약제학회 2013 Journal of Pharmaceutical Investigation Vol.43 No.4
The objective of present study was to develop nanostructured lipid carriers (NLC) for topical delivery of antioxidant drug and evaluation of its sun protection efficacy. In the present study attempts have been made to formulate Idebenone loaded nanostructured lipid carriers (INLC) by using solvent precipitation method. Preformulation study evidenced for selection of Captex 500 P as an oil phase in which Idebenone has saturation solubility of 0.266 ±0.032 g/ml. Compritol 888 ATO and ethanol were selected as solid lipid and solvent respectively. Surfactant and cosurfactant as Labrasol and Transcutol P have given stable formulations on the basis of HLB required for stabilization,respect to oil phase. INLC has particle size of 605 ±4.01 nm and %EE of 82.58 ± 2.20 %. Optimized batches were subjected for crystallographic investigation, in vitro skin permeation study, drug deposition study, SPF determination and antioxidant activity. XRD, DSC studies illustrated that partial amorphization of Idebenone by molecularly dispersion within lipid blend leads for entrapment of drug. Permeation data showed that optimized INLC has flux value (Jss)of 7.87 lg cm-2 h-1. High significance (P\0.001) of drug deposition in skin was observed between INLC and plain Idebenone gel. SPF value for INLC has 23which represents that lipid nanocarriers have standards of blocking of 94–96 % of UVB rays. Such high skin deposition and SPF leads to more antioxidant effect of formulations. Hence lipid nanocarriers such as NLC have potential as an antioxidant and sun protection for topical drug delivery.
N. H. Salunkhe,N. R. Jadhav,K. K. Mali,R. J. Dias,V. S. Ghorpade,A. V. Yadav 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.4
The purpose of present work was to developsuppositories containing mucoadhesive microspheres ofgranisetron hydrochloride (GH) using combination ofxanthan gum and sodium alginate. Twelve different batchesof microspheres containing GH were prepared bysimple emulsification method and evaluated for surfacemorphology, particle size, equilibrium swelling degree,drug content, in vitro mucoadhesion, and in vitro drugrelease. The suppositories containing optimized batch ofmicrospheres (C2) were formulated by fusion method usinghydrophilic and lipophilic polymer base. The suppositorieswere evaluated for weight variation, hardness, macromeltingrange, drug content, drug release, morphology ofrectal tissues, and in vivo suppository localization. Resultsshow that, all microsphere batches were spherical and hadsize range 23.56–36.76 lm. The % drug encapsulation wasfound in the range 61.67–92.30 %, and showed satisfactorymucoadhesion. Especially, C2 batch had 83.67 % mucoadhesionand 92.30 % drug encapsulation and showedrelease retardation for 4 h. The results of all suppositorieswere within the pharmacopoeial standard limits. Drugcontent of all the suppositories was in the range93.20–98.40 %. The suppository batch (P2M) wasconsidered best on the basis of optimum retardation up to5 h, high drug content, optimum mechanical strength andzero order release (r2 = 0.9860). The suppository of batchP2M showed no morphological changes in rectal tissuesindicating its safety. In vivo localization revealed satisfactorymucoadhesion of microspheres. Hence, it can beconcluded that, delivery of GH in suppository form canavoid its presystemic metabolism, thus, may be an efficientalternative to its oral dosage form and conventionalsuppository.
Shelke, Sharad,Salunkhe, Nilesh,Sangale, Sandeep,Bhalerao, Swapnil,Naik, Nilesh,Mhaske, Ganesh,Jadhav, Ranjana,Karale, Bhausaheb Korean Chemical Society 2010 대한화학회지 Vol.54 No.1
일련의 불소화된 티아디아졸 3, 트리아졸 4, 그리고 옥사디아졸 5이 (2-(6-Methyl-2-P-tolyl-lH-imidazo[1,2-a]pyridin-3-yl)핵종을 가지고 있는 티오세미카르바지드로 부터 합성되어진다. 초음파조사 방법 뿐만 아니라 일반적인 방법에 의해 반응이 진행되었다. 모든 생성물들은 IR, 1H NMR, MS로 구조가 결정되었고, 이들 화합물의 항균활성을 스크닝하였다. The synthesis of a series of fluorinated thiadiazoles 3, triazoles 4 and oxadiazoles 5 are synthesized from thiosemicarbazides 2 containing (2-(6-methyl-2-p-tolyl-lH-imidazo[1,2-a]pyridin-3-yl nucleus. These reactions were carried out by conventional method as well as ultra sound irradiation method. All products have been characterized by IR, 1H NMR, MS study and screened for their antimicrobial activity.
Park, Kyung Sun,Salunkhe, Sonali M.,Lim, Iseul,Cho, Cheon‐,Gyu,Han, Sung‐,Hwan,Sung, Myung Mo WILEY‐VCH Verlag 2013 Advanced Materials Vol.25 No.24
<P><B>A new indolocabazole derivative possessing an extended aromatic core and solubilizing long aliphatic chains</B> effectively self‐assembles and crystallizes within the nanoscale channels to form single‐crystal nanowires via a direct printing method from an ink solution. Single‐crystal organic nanowire transistor arrays based on the <I>π</I>‐extended indolocarbazole derivative exhibit an excellent hole mobility of 1.5 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP> and outstanding environmental stability.</P>
Kaneti, Yusuf Valentino,Salunkhe, Rahul R.,Wulan Septiani, Ni Luh,Young, Christine,Jiang, Xuchuan,He, Yan-Bing,Kang, Yong-Mook,Sugahara, Yoshiyuki,Yamauchi, Yusuke The Royal Society of Chemistry 2018 Journal of materials chemistry. A, Materials for e Vol.6 No.14
<P>In this work, we propose a general template-free strategy for fabricating two-dimensional mesoporous mixed oxide nanosheets, such as metal cobaltites (MCo2O4, M = Ni, Zn) through the self-deconstruction/reconstruction of highly uniform Co-based metal glycerate nanospheres into 2D Co-based metal glycerate/hydroxide nanosheets, induced by the so-called “water treatment” process at room temperature followed by their calcination in air at 260 °C. The proposed ‘self-deconstruction/reconstruction’ strategy is highly advantageous as the resulting 2D metal cobaltite nanosheets possess very high surface areas (150-200 m<SUP>2</SUP>g<SUP>−1</SUP>) and mesoporous features with narrow pore size distribution. In addition, our proposed method also enables the crystallization temperature to achieve pure metal cobaltite phase from the precursor phase to be lowered by 50 °C. Using the 2D mesoporous NiCo2O4nanosheets as a representative sample, we found that they exhibit 6-20 times higher specific capacitance and greatly enhanced capacitance retention compared to the NiCo2O4nanospheres achieved through the direct calcination of the Ni-Co glycerate nanospheres. This highlights another advantage of the proposed strategy for enhancing the electrochemical performance of the mixed oxide products for supercapacitor applications. Furthermore, the asymmetric supercapacitor (ASC) assembled using the 2D NiCo2O4nanosheets//graphene oxide (GO) exhibits a maximum energy density of 38.53 W h kg<SUP>−1</SUP>, while also showing a high capacitance retention of 91% after 2000 cycles at 5 A g<SUP>−1</SUP>. It is expected that the proposed general method may be extended to other transition metal elements for creating 2D mixed oxide nanosheets with enhanced surface areas and improved electrochemical performance.</P>