Frequency of Chromosomal Abnormalities in Pakistani Adults with Acute Lymphoblastic Leukemia

Shaikh, Muhammad Shariq,Adil, Salman Naseem,Shaikh, Mohammad Usman,Khurshid, Mohammad Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Background: The difference in prognosis of adult and childhood acute lymphoblastic leukemia (ALL) can be attributed largely to variation in cytogenetic abnormalities with age groups. Cytogenetic analysis in acute leukemia is now routinely used to assist patient management, particularly in terms of diagnosis, disease monitoring, prognosis and risk stratification. Knowing about cytogenetic profile at the time of diagnosis is important in order to take critical decisions in management of the patients. Aim and Objectives: To determine the frequency of cytogenetic abnormalities in Pakistani adult patients with ALL in order to have insights regarding behavior of the disease. Materials and Methods: A retrospective analysis of all the cases of ALL (${\geq}15$years old) diagnosed at Aga Khan University from January 2006 to June 2014 was performed. Phenotype (B/T lineage) was confirmed in all cases by flow cytometry. Cytogenetic analysis was made for all cases using the trypsin-Giemsa banding technique. Karyotypes were interpreted using the International System for Human Cytogenetic Nomenclature (ISCN) criteria. Results: A total of 166 patients were diagnosed as ALL during the study period, of which 151 samples successfully yielded metaphase chromosomes. The male to female ratio was 3.4:1. The majority (n=120, 72.3%) had a B-cell phenotype. A normal karyotype was present in 51% (n=77) of the cases whereas 49% (n=74) had an abnormal karyotype. Of the abnormal cases, 10% showed Philadelphia chromosome; t(9;22)(q34;q11.2). Other poor prognostic cytogenetic subgroups were t(4;11)(q21;q23), hypodiploidy (35-45 chromosomes) and complex karyotype. Hyperdiploidy (47-57 chromosomes) occurred in 6.6%; all of whom were younger than 30 years. Conclusions: This study showed a relatively low prevalence of Philadelphia chromosome in Pakistani adults with ALL with an increase in frequency with age (p=0.003). The cumulative prevalence of Philadelphianegative poor cytogenetic aberrations in different age groups was not significant (p=0.6).

Surgical Techniques for Thoracolumbar Spine Fractures: WFNS Spine Committee Recommendations

Salman Sharif,Yousuf Shaikh,Onur Yaman,Mehmet Zileli 대한척추신경외과학회 2021 Neurospine Vol.18 No.4

To formulate the specific guidelines for the recommendation of thoracolumbar fracture regarding surgical techniques and nonfusion surgery. WFNS (World Federation of Neurosurgical Societies) Spine Committee organized 2 consensus meeting. For nonfusion surgery and thoracolumbar fracture, a systematic literature search in PubMed and Google Scholar database was done from 2010 to 2020. The search was further refined by excluding the articles which were duplicate, not in English or were based on animal or cadaveric subjects. After thorough shortlisting, only 50 articles were selected for full review in this consensus meeting. To generate a consensus, the levels of agreement or disagreement on each item were voted independently in a blind fashion through a Likert-type scale from 1 to 5. The consensus was achieved when the sum for disagreement or agreement was ≥66%. Each consensus point was clearly defined with evidence strength, recommendation grade, and consensus level provided. A magnitude of prospective papers were analyzed to formulate consensus on various surgical techniques that can be employed to address different types of thoracolumbar fractures. Surgical treatment of thoracolumbar fractures can be a better option over the nonoperative approach, especially for those who cannot tolerate months in an orthosis or cast, such as those with multiple extremity injuries, skin lesions, obesity, and so forth. It generally allows early mobilization, less hospital stay, reduced pulmonary complications, and better correction of sagittal balance. Current available literature fails to demonstrate any statistically significant benefit of fusion surgery over nonfusion in thoracolumbar fractures.

LDCSIR: Lightweight Deep CNN-based Approach for Single Image Super-Resolution

Muhammad, Wazir,Shaikh, Murtaza Hussain,Shah, Jalal,Shah, Syed Ali Raza,Bhutto, Zuhaibuddin,Lehri, Liaquat Ali,Hussain, Ayaz,Masrour, Salman,Ali, Shamshad,Thaheem, Imdadullah International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.spc12

Single image super-resolution (SISR) is an image processing technique, and its main target is to reconstruct the high-quality or high-resolution (HR) image from the low-quality or low-resolution (LR) image. Currently, deep learning-based convolutional neural network (CNN) image super-resolution approaches achieved remarkable improvement over the previous approaches. Furthermore, earlier approaches used hand designed filter to upscale the LR image into HR image. The design architecture of such approaches is easy, but it introduces the extra unwanted pixels in the reconstructed image. To resolve these issues, we propose novel deep learning-based approach known as Lightweight deep CNN-based approach for Single Image Super-Resolution (LDCSIR). In this paper, we propose a new architecture which is inspired by ResNet with Inception blocks, which significantly drop the computational cost of the model and increase the processing time for reconstructing the HR image. Compared with the other state of the art methods, LDCSIR achieves better performance in terms of quantitively (PSNR/SSIM) and qualitatively.

LDCSIR: Lightweight Deep CNN-based Approach for Single Image Super-Resolution

Muhammad, Wazir,Shaikh, Murtaza Hussain,Shah, Jalal,Shah, Syed Ali Raza,Bhutto, Zuhaibuddin,Lehri, Liaquat Ali,Hussain, Ayaz,Masrour, Salman,Ali, Shamshad,Thaheem, Imdadullah International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.12

Single image super-resolution (SISR) is an image processing technique, and its main target is to reconstruct the high-quality or high-resolution (HR) image from the low-quality or low-resolution (LR) image. Currently, deep learning-based convolutional neural network (CNN) image super-resolution approaches achieved remarkable improvement over the previous approaches. Furthermore, earlier approaches used hand designed filter to upscale the LR image into HR image. The design architecture of such approaches is easy, but it introduces the extra unwanted pixels in the reconstructed image. To resolve these issues, we propose novel deep learning-based approach known as Lightweight deep CNN-based approach for Single Image Super-Resolution (LDCSIR). In this paper, we propose a new architecture which is inspired by ResNet with Inception blocks, which significantly drop the computational cost of the model and increase the processing time for reconstructing the HR image. Compared with the other state of the art methods, LDCSIR achieves better performance in terms of quantitively (PSNR/SSIM) and qualitatively.

Clinical and Radiological Factors Affecting Thoracolumbar Fractures Outcome: WFNS Spine Committee Recommendations

Francesco Costa,Salman Sharif,Abdul Hafid Bajamal,Yousuf Shaikh,Carla D. Anania,Mehmet Zileli 대한척추신경외과학회 2021 Neurospine Vol.18 No.4

To obtain a list of recommendations about clinical and radiological factors affecting outcome in thoraco-lumbar fractures with the aim of helping spine surgeons in daily practice. A systematic literature search in PubMed and Google Scholar database was done from 2010 to 2020 on the topic “thoracolumbar fracture AND radiology AND surgical outcomes” and “thoracolumbar fracture AND radiology AND surgical outcomes.” A total of 58 papers were analyzed and WFNS (World Federation of Neurosurgical Societies) Spine Committee organized 2 consensus meetings to formulate the specific recommendations the first in Peshawar in December 2019 and in a subsequent virtual meeting in June 2020 to reach an agreement. Both meetings utilized the Delphi method to analyze preliminary literature review statements based on the current evidence levels to generate recommendations through a comprehensive voting session. Eight statements were presented and reached the consensus about this topic. A variety of clinical factors is known to influence outcome of patients with thoracolumbar fractures. Some of these are well-known established factors such as blood pressure augmentation and patient age, while some are not well studied. Overall, the quality of evidence is low and we need more randomized controlled studies to validate our results. Similarly, radiological factors that can predict outcome are well stated and there is a high accordance worldwide. In reverse, still under debate is the application to choose which surgical treatment is advisable based on them.

The Social Environment in the Development of Entrepreneurial Idea Generation and Development

MAITLO, Ayaz Ali,MEMON, Salman Bashir,SHAIKH, Iram Rani Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.10

The role of the social environment for any activity is crucial as it prompts new ideas and plays a role of lever for entrepreneurial longevity and creating value through social wellbeing. The lack of entrepreneurship related knowledge in Pakistan has taken the challenge of lesser entrepreneurial activity as compared to other counterpart Asian countries and ranked 138 out of 189 countries on the level of ease of doing business. The study aims to investigate the social environment as a mediator among idea generation, business creation, financing decision and entrepreneurial activity by utilizing quantitative approach. In order to achieve the objective, a total of thirty eight items scale was self-administered for data collection. A non-probability, snowball sampling technique was employed and assembled a total of 300 complete responses through online and paper based surveys as per information provided by the chamber of commerce of three regions namely; Sukkur, Hyderabad and Karachi Sindh, Pakistan. The data analysis result strongly supported the main research question as the entrepreneurial activity increased up to 43.8% after applying social environment as a mediator. This research can help to enhance entrepreneurial activities in Pakistan by creating awareness to support entrepreneurs at social level for entrepreneurship.

Breast Self Examination Practice and Breast Cancer Risk Perception among Female University Students in Ajman

Al-Sharbatti, Shatha Saed,Shaikh, Rizwana Burhanuddin,Mathew, Elsheba,Al-Biate, Mawahib Abd Salman Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Breast cancer is the top cancer in women worldwide and its incidence is increasing, particularly in developing countries. In the United Arab Emirates (UAE), many cases are first diagnosed in later stages and at younger age compared to those seen in developed countries. Early detection in order to improve breast cancer outcome and survival remains the cornerstone of breast cancer control. Performance of breast self examination is one of the important steps for identifying breast disease at an early stage, by the woman herself. No information has hitherto been available about the frequency of this practice among female university students in UAE or about their breast cancer risk perception and therefore the present study was conducted in Ajman. It was found that 22.7% of the participants practiced BSE but only 3% of them practiced BSE monthly. Marital status but not age as significantly associated with age likelihood. The most frequent reported barriers for BSE were lack of knowledge, considering oneself not at risk and the absence of doctor advice. These factors need to be taken into account in intervention efforts.

Navigated intraoperative ultrasonography for brain tumors: a pictorial essay on the technique, its utility, and its benefits in neuro-oncology

Ujwal Yeole,Vikas Singh,Ajit Mishra,Salman Shaikh,Prakash Shetty,Aliasgar Moiyadi 대한초음파의학회 2020 ULTRASONOGRAPHY Vol.39 No.4

Intraoperative imaging has become one of the most important adjuncts in neurosurgery, especially in the surgical treatment of intra-axial tumors. Navigation and intraoperative magnetic resonance imaging have limitations, and intraoperative ultrasonography (IOUS) has emerged as a versatile and multifaceted alternative. With technological advances in ultrasound scanners and newer multifunctional probes, the potential of IOUS is increasingly being utilized in the resection of tumors. The addition of image guidance to IOUS has exponentially increased the power of this technique. Navigated ultrasonography (nUS) can now overcome many of the limitations of conventional standalone two-dimensional ultrasonography. In this pictorial essay, we outline our nUS technique (both two- and three-dimensional) for the resection of intra-axial tumors with illustrated examples highlighting the various steps and corresponding benefits of the technique.

Endoscopic Third Ventriculostomy : Success and Failure

Deopujari, Chandrashekhar E.,Karmarkar, Vikram S.,Shaikh, Salman T. The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.3

Endoscopic third ventriculostomy (ETV) has now become an accepted mode of hydrocephalus treatment in children. Varying degrees of success for the procedure have been reported depending on the type and etiology of hydrocephalus, age of the patient and certain technical parameters. Review of these factors for predictability of success, complications and validation of success score is presented.