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Vladimir A. Basiuk,Marco Salerno,Alejandro Heredia,Elena V. Basiuk 한국섬유공학회 2018 Fibers and polymers Vol.19 No.8
Bolas spiders of the genus Mastophora are very uncommon orb-weaver spiders, famous for their unusual predatory behavior. Being strictly nocturnal and very cryptic, they are extremely difficult to reveal, which explains their rarity in world arachnological collections. After a recent finding of an adult female of Mastophora corpulenta Banks (one of especially rare representatives of the genus), a few egg cases of this species became available, which seem to be very different from those of more common spiders due to their unusual hardness and coloration. We characterized some spectral, structural, and mechanical properties of this unusual silk material, by using Fourier-transform infrared spectroscopy, scanning electron microscopy (SEM), 3D profilometer imaging, and atomic force microscopy (AFM). For comparison, similar studies were performed for egg cases of the Southern black widow Latrodectus mactans Fabricius, since spiders of the genus Latrodectus are known to produce silk fibers of comparable toughness. Some similarities were observed between the silks produced by Mastophora corpulenta and Latrodectus mactans in terms of the size and chemical composition of egg cases. At the same time, SEM imaging and AFM force characterization revealed striking differences between them, due to the fact that Mastophora egg cases, unlike those produced by more common Araneae species, includes a solid (fused) wall, lacking evident porous structure, which results in their outstanding stiffness and strength.
Kweh Mercedes F.,Parks Megan,Salerno Alessandro,Vaughn Natalie E.,White Ian A. 대한창상학회 2023 Journal of Wound Management and Research Vol.19 No.1
Full-thickness burns almost always require skin grafting because the severity prevents the natural regenerative process. Here, we illustrate the potential to promote natural skin regeneration utilizing growth factors and regenerative proteins in purified amniotic fluid (PAF). A 24-year-old female suffered from full-thickness burns to her legs resulting from a rogue firework. This initiated a treatment plan involving extensive rehabilitation and skin grafting. Instead, the patient was treated with PAF (4 mL) administered topically over 2 days. Forty-five minutes following application, her pain decreased from 10/10 to 2/10. After two treatments her overall recovery time decreased by 75%–leaving her physicians surprised at the obviated need for skin grafting. Topical PAF relieved pain within minutes, making it easier to clean the affected area, enhancing sleep, and allowing more range of motion and autonomy. The efficiency of PAF to reduce pain allowed the patient to discontinue the use of prescribed hydrocodone, an opioid that is fueling an epidemic of abuse and addiction. Accelerated recovery time allowed the patient to return to work sooner, having broader economic implications on medical costs and personal time off. Finally, PAF enhanced the body’s own capacity to heal itself, avoiding painful and costly grafting and decreasing additional donor site scarring.
Rossella Marino,Laura Magrini,Francesca Orsini,Veronica Russo,Patrizia Cardelli,Gerardo Salerno,허미나,Salvatore Di Somma 대한진단검사의학회 2017 Annals of Laboratory Medicine Vol.37 No.2
Background: High-sensitivity cardiac troponin I (hs-cTnI) and the soluble isoform of suppression of tumorigenicity 2 (sST2) are useful prognostic biomarkers in acute coronary syndrome (ACS). The aim of this study was to test the short term prognostic value of sST2 compared with hs-cTnI in patients with chest pain. Methods: Assays for hs-cTnI and sST2 were performed in 157 patients admitted to the Emergency Department (ED) for chest pain at arrival. In-hospital and 30-day follow-up mortalities were assessed. Results: The incidence of ACS was 37%; 33 patients were diagnosed with ST elevation myocardial infarction (STEMI), and 25 were diagnosed with non-ST elevation myocardial infarction (NSTEMI). Compared with the no acute coronary syndrome (NO ACS) group, the median level of hs-cTnI was higher in ACS patients: 7.22 (5.24-14) pg/mL vs 68 (15.33 -163.50) pg/mL (P<0.0001). In all patients, the sST2 level at arrival showed higher independent predictive power than hs-cTnI (odds ratio [OR] 20.13, P<0.0001 and OR 2.61, P<0.0008, respectively). sST2 at ED arrival showed a greater prognostic value for cardiovascular events in STEMI (area under the curve [AUC] 0.80, P<0.001) than NSTEMI patients (AUC 0.72, P<0.05). Overall, 51% of the STEMI patients with an sST2 value>35 ng/mL at ED arrival died during the 30-day follow-up. Conclusions: sST2 has a greater prognostic value for 30-day cardiac mortality after discharge in patients presenting to the ED for chest pain compared with hs-cTnI. In STEMI patients, an sST2 value >35 ng/mL at ED arrival showed the highest predictive power for short-term mortality.
Autophagy-related protein LC3 and Beclin-1 in the first trimester of pregnancy
Chifenti, Barbara,Locci, Maria Teresa,Lazzeri, Gloria,Guagnozzi, Mariangela,Dinucci, Dino,Chiellini, Federica,Filice, Maria Elena,Salerno, Maria Giovanna,Battini, Lorella The Korean Society for Reproductive Medicine 2013 Clinical and Experimental Reproductive Medicine Vol.40 No.1
Autophagy is a degradation process that acts in response to environmental stressors. Recently, autophagy has been detected in normal term, preeclamptic and intrauterine growth-restricted placentas. The object of this work was to investigate the presence of autophagy in first trimester voluntary interruption of pregnancy placental villi by the expression of autophagy-related proteins, light chain 3 (LC3), and Beclin-1. In first trimester placental villi laser scanning confocal microscopy (LSCM) analysis revealed LC3 and Beclin-1 immunoreactivity prevalently located in villous cytotrophoblasts. Using LSCM, LC3, and Beclin-1 were localized to the cytoplasm of the trophoblast layer in human full-term placentas. Beclin-1 expression and LC3 activation were confirmed by western blotting. These data emphasize that autophagy activation is different among cytotrophoblasts and syncytiotrophoblasts depending on the gestational age and thus we speculate that autophagy might play a prosurvival role throughout human pregnancy.