Role of telomere Length in subtelomeric gene expression and its possible relation to cellular senescence

( Hernandez Caballero E. ),( Herrera Gonzalez N. E. ),( Salamanca Gomez F. ),( Arenas Aranda D. J. ) 생화학분자생물학회 2009 BMB Reports Vol.42 No.11

Assessment of buccal bone thickness of aesthetic maxillary region: a conebeam computed tomography study

Ramón Fuentes,Tania Flores,Pablo Navarro,Carlos Salamanca,Víctor Beltrán,Eduardo Borie 대한치주과학회 2015 Journal of Periodontal & Implant Science Vol.45 No.5

Purpose: The aim of this study was to analyze the anatomical dimensions of the buccal bone walls of the aesthetic maxillary region for immediate implant placement, based upon cone-beam computed tomography (CBCT) scans in a sample of adult patients. Methods: Two calibrated examiners analyzed a sample of 50 CBCT scans, performing mor¬phometric analyses of both incisors and canines on the left and right sides. Subsequently, in the sagittal view, a line was traced through the major axis of the selected tooth. Then, a second line (E) was traced from the buccal to the palatal wall at the level of the observed bone ridges. The heights of the buccal and palatal bone ridges were determined at the ma¬jor axis of the tooth. The buccal bone thickness was measured across five lines. The first was at the level of line E. The second was at the most apical point of the tooth, and the other three lines were equidistant between the apical and the cervical lines, and parallel to them. Statistical analysis was performed with a significance level of P≤0.05 for the bone thick¬ness means and standard deviations per tooth and patient for the five lines at varying depths. Results: The means of the buccal wall thicknesses in the central incisors, lateral incisors and canines were 1.14±0.65 mm, 0.95±0.67 mm and 1.15±0.68 mm, respectively. Additionally, only on the left side were significant differences in some measurements of buccal bone thickness observed according to age and gender. However, age and gender did not show significant differences in heights between the palatal and buccal plates. In a few cases, the buccal wall had a greater height than the palatal wall. Conclusions: Less than 10% of sites showed more than a 2-mm thickness of the buccal bone wall, with the exception of the central incisor region, wherein 14.4% of cases were ≥2 mm.

Assessment of buccal bone thickness of aesthetic maxillary region: a cone-beam computed tomography study

Fuentes, Ramon,Flores, Tania,Navarro, Pablo,Salamanca, Carlos,Beltran, Victor,Borie, Eduardo Korean Academy of Periodontology 2015 Journal of Periodontal & Implant Science Vol.45 No.5

Purpose: The aim of this study was to analyze the anatomical dimensions of the buccal bone walls of the aesthetic maxillary region for immediate implant placement, based upon cone-beam computed tomography (CBCT) scans in a sample of adult patients. Methods: Two calibrated examiners analyzed a sample of 50 CBCT scans, performing morphometric analyses of both incisors and canines on the left and right sides. Subsequently, in the sagittal view, a line was traced through the major axis of the selected tooth. Then, a second line (E) was traced from the buccal to the palatal wall at the level of the observed bone ridges. The heights of the buccal and palatal bone ridges were determined at the major axis of the tooth. The buccal bone thickness was measured across five lines. The first was at the level of line E. The second was at the most apical point of the tooth, and the other three lines were equidistant between the apical and the cervical lines, and parallel to them. Statistical analysis was performed with a significance level of $P{\leq}0.05$ for the bone thickness means and standard deviations per tooth and patient for the five lines at varying depths. Results: The means of the buccal wall thicknesses in the central incisors, lateral incisors and canines were $1.14{\pm}0.65mm$, $0.95{\pm}0.67mm$ and $1.15{\pm}0.68mm$, respectively. Additionally, only on the left side were significant differences in some measurements of buccal bone thickness observed according to age and gender. However, age and gender did not show significant differences in heights between the palatal and buccal plates. In a few cases, the buccal wall had a greater height than the palatal wall. Conclusions: Less than 10% of sites showed more than a 2-mm thickness of the buccal bone wall, with the exception of the central incisor region, wherein 14.4% of cases were ${\geq}2mm$.

Low-intensity extracorporeal shock wave therapy for erectile dysfunction: Myths and realities

Alessia Celeste Bocchino,Marta Pezzoli,Juan Ignacio Martínez-Salamanca,Giorgio Ivan Russo,Arturo Lo Giudice,Andrea Cocci 대한비뇨의학회 2023 Investigative and Clinical Urology Vol.64 No.2

To review the evidence of clinical efficacy of low-intensity extracorporeal shock wave therapy (Li-ESWT) for the treatment of erectile dysfunction (ED). A search on PubMed using Medical Subject Headings terms [((low intensity extracorporeal shockwave therapy) OR (Li-ESWT)) AND (erectile dysfunction)] was conducted in August 2022, to obtain studies on the use of Li-ESWT for the treatment of ED. Its success rate in terms of International Index of Erectile Function-5 (IIEF-5) score and Erection Hardness Score (EHS) improvement was recorded and analysed. A total of 139 articles were reviewed. Overall, 52 studies were included in the final review. 17 studies were on vasculogenic ED, 5 on post pelvic surgery ED, 4 specifically on ED in diabetic patients, 24 on non-specified origin ED and 2 on mixed pathophysiological origin ED. The mean age of patients was 55.87±7.91 (standard deviation) years and the duration of ED was 4.36±2.08 years. The mean IIEF-5 score went from 12.04±2.67 at baseline to 16.12±5.72, 16.30±3.26 and 16.85±1.63 respectively at 3, 6 and 12 months. The mean EHS went from 2.00±0.46 at baseline to 2.58±0.60, 2.75±0.46 and 2.87±0.16 respectively at 3, 6 and 12 months. Li-ESWT may be a safe and efficacy option for the treatment and cure of ED. Further studies are needed to assess which patients are more suitable for this procedure and which Li-ESWT protocol can lead to the best outcomes.

The Demographics of galactic bulges in the SDSS database

Keunho Kim,Sree Oh,Hyunjin Jeong,Alfonso Aragόn-Salamanca,Rory Smith,Sukyoung K. Yi 한국천문학회 2016 天文學會報 Vol.41 No.1

THE DEMOGRAPHICS OF GALACTIC BULGES IN THE SDSS DATABASE

Kim, Keunho,Oh, Sree,Jeong, Hyunjin,Aragó,n-Salamanca, Alfonso,Smith, Rory,Yi, Sukyoung K. American Astronomical Society 2016 The Astrophysical journal Supplement series Vol.225 No.1

<P>We present a new database of our two-dimensional bulge-disk decompositions for 14,233 galaxies drawn from Sloan Digital Sky Survey DR12 in order to examine the properties of bulges residing in the local universe (0.005 < z < 0.05). We performed decompositions in the g and r bands by utilizing the GALFIT software. The bulge colors and bulge-to-total ratios are found to be sensitive to the details in the decomposition technique, and hence we hereby provide full details of our method. The g - r colors of bulges derived are almost constantly red regardless of bulge size, except for the bulges in the low bulge-to-total ratio galaxies (B/T-r less than or similar to 0.3). Bulges exhibit similar scaling relations to those followed by elliptical galaxies, but the bulges in galaxies with lower bulge-to-total ratios clearly show a gradually larger departure in slope from the elliptical galaxy sequence. The scatters around the scaling relations are also larger for the bulges in galaxies with lower bulge-to-total ratios. Both the departure in slopes and larger scatters likely originate from the presence of young stars. The bulges in galaxies with low bulge-to-total ratios show signs of a frosting of young stars so substantial that their luminosity-weighted Balmer-line ages are as small as 1 Gyr in some cases. While bulges seem largely similar in optical properties to elliptical galaxies, they do show clear and systematic departures as a function of bulge-to-total ratio. The stellar properties and perhaps associated formation processes of bulges seem much more diverse than those of elliptical galaxies.</P>

The 13th Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the SDSS-IV Survey Mapping Nearby Galaxies at Apache Point Observatory

Albareti, Franco D.,Prieto, Carlos Allende,Almeida, Andres,Anders, Friedrich,Anderson, Scott,Andrews, Brett H.,Aragó,n-Salamanca, Alfonso,Argudo-Ferná,ndez, Maria,Armengaud, Eric,Aubourg, American Astronomical Society 2017 The Astrophysical journal Supplement series Vol.233 No.2

<P>The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) began observations in 2014 July. It pursues three core programs: the Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2), Mapping Nearby Galaxies at APO (MaNGA), and the Extended Baryon Oscillation Spectroscopic Survey (eBOSS). As well as its core program, eBOSS contains two major subprograms: the Time Domain Spectroscopic Survey (TDSS) and the SPectroscopic IDentification of ERosita Sources (SPIDERS). This paper describes the first data release from SDSS-IV, Data Release 13 (DR13). DR13 makes publicly available the first 1390 spatially resolved integral field unit observations of nearby galaxies from MaNGA. It includes new observations from eBOSS, completing the Sloan Extended QUasar, Emission-line galaxy, Luminous red galaxy Survey (SEQUELS), which also targeted variability-selected objects and X-ray-selected objects. DR13 includes new reductions of the SDSS-III BOSS data, improving the spectrophotometric calibration and redshift classification, and new reductions of the SDSS-III APOGEE-1 data, improving stellar parameters for dwarf stars and cooler stars. DR13 provides more robust and precise photometric calibrations. Value-added target catalogs relevant for eBOSS, TDSS, and SPIDERS and an updated red-clump catalog for APOGEE are also available. This paper describes the location and format of the data and provides references to important technical papers. The SDSS web site, http://www.sdss.org, provides links to the data, tutorials, examples of data access, and extensive documentation of the reduction and analysis procedures. DR13 is the first of a scheduled set that will contain new data and analyses from the planned similar to 6 yr operations of SDSS-IV.</P>

Prognostic models for locally advanced cervical cancer: external validation of the published models

David Lora,Agustín Gómez de la Cámara,Sara Pedraza Fernández,Rafael Enríquez de Salamanca,José Fermín Pérez-Regadera Gómez 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5

Objective: To externally validate the prognostic models for predicting the time-dependentoutcome in patients with locally advanced cervical cancer (LACC) who were treated withconcurrent chemoradiotherapy in an independient cohort. Methods: A historical cohort of 297 women with LACC who were treated with radicalconcurrent chemoradiotherapy from 1999 to 2014 at the 12 de Octubre University Hospital(H12O), Madrid, Spain. The external validity of prognostic models was quantified regardingdiscrimination, calibration, measures of overall performance, and decision curve analyses. Results: The review identified 8 studies containing 13 prognostic models. Different(International Federation of Gynecology and Obstetrics [FIGO] stages, parametriuminvolvement, hydronephrosis, location of positive nodes, and race) but related cohorts withvalidation cohort (5-year overall survival [OS]=70%; 5-year disease-free survival [DFS]=64%;average age of 50; and over 79% squamous cell) were evaluated. The following models exhibitedgood external validity in terms of discrimination and calibration but limited clinical utility: theOS model at 3 year from Kidd et al.'s study (area under the receiver operating characteristiccurve [AUROC]=0.69; threshold of clinical utility [TCU] between 36% and 50%), the models ofDFS at 1 year from Kidd et al.'s study (AUROC=0.64; TCU between 24% and 32%) and 2 yearsfrom Rose et al.'s study (AUROC=0.70; TCU between 19% and 58%) and the distant recurrencemodel at 5 years from Kang et al.'s study (AUROC=0.67; TCU between 12% and 36%). Conclusion: The external validation revealed the statistical and clinical usefulness of 4prognostic models published in the literature.

Risk Factors for Revision After Artificial Urinary Sphincter Implantation in Male Patients With Stress Urinary Incontinence: A 10-Year Retrospective Study

Celeste Manfredi,Pramod Krishnappa,Esaú Fernández-Pascual,Elena García Criado,Diego Rengifo,David Vázquez Alba,Joaquín Carballido,Davide Arcaniolo,Juan Ignacio Martínez-Salamanca 대한배뇨장애요실금학회 2022 International Neurourology Journal Vol.26 No.2

Purpose: To evaluate the preoperative and intraoperative risk factors for revision after artificial urinary sphincter (AUS) implantation in male patients with stress urinary incontinence (SUI). Methods: A retrospective analysis from a prospectively maintained database was performed. Male patients, with moderate-tosevere SUI, undergoing AUS implantation were included. All patients underwent placement of AMS 800. Cause of revision, type of revision, and time to revision were recorded. Multivariable analyzes were performed using a logistic regression to investigate the risk factors. Competing risk analysis according to Fine-Gray model was used to study time to event data. Results: A total of 70 patients were included. Revision surgery was performed in 22 of 70 patients (31.4%), after a median (interquartile range) time of 26.5 months (6.5–39.3 months). Overall, 19 of 22 repairs (86.4%) and 3 of 22 explants (13.6%) were recorded. Mechanical dysfunction, urethral erosion, urethral atrophy, and device infection were the causes of revision in 11 of 22 (50.0%), 6 of 22 (27.3%), 3 of 22 (13.6%), and 2 of 22 patients (9.1%). Vesicourethral anastomosis stenosis (P=0.02), urethral cuff size of 3.5 cm (P=0.029), and dual implantation (P=0.048) were independent predictors for revision. Vesicourethral anastomosis stenosis (P=0.01) and urethral cuff size of 3.5 cm (P=0.029) predicted a lower survival of the AUS. Conclusions: The vesicourethral anastomosis stenosis, urethral cuff size of 3.5 cm, and dual implantation are independent predictors for revision after AUS implantation. However, only the vesicourethral anastomosis stenosis and urethral cuff size of 3.5 cm predict a lower survival of AUS.