Incidence and Mortality of Testicular Cancer and Relationships with Development in Asia

Sadeghi, Mostafa,Ghoncheh, Mahshid,Mohammadian-Hafshejani, Abdollah,Gandomani, Hamidreza Sadeghi,Rafiemanesh, Hosein,Salehiniya, Hamid Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9

Background: Testicular cancer is one of the most common cancers among young men between ages 20-34 in countries with high or very high levels of the Human Development Index (HDI). This study investigated the incidence and mortality of prostate cancer and the relationship with the HDI and its dimensions in Asia in 2012. Materials and Methods: The study was conducted based on data from the world data of cancer and the World Bank (including the HDI and its components). Standardized incidence and mortality rates of testicular cancer were calculated for Asian countries. Correlations between incidence and/ormortality rates, and the HDI and its components were assessed with the use of the correlation test, using SPSS software. Results: There was a total of 14902 incidences and 5832 death were recorded in Asian countries in 2012. Among the Asian countries, the five countries with the highest standardized incidence rates of testicular cancer were Israel, Georgia, Turkey, Lebanon and Kazakhstan and the five countries with the highest standardized mortality rates were Turkey, Georgia, Jordan, Cambodia and the Syrian Arab Republic. A positive correlation of 0.382 was observed between the standardized incidence rates of testicular cancer and the HDI (p=0.009). Also a negative correlation of 0.298 between the standardized mortality rate of testicular cancer and the Human Development Index was noted although this relation was statistically non-significant (p=0.052). Conclusions: There is a positive correlation between HDI and the standardized incidence rate of testicular cancer and negative correlation with standardized mortality rate.

A Case Report of Prolonged Hemorrhage Following Traditional Phlebotomy (Fasd)

Sadeghi Sajjad,Sadeghi Sajjad 대한약침학회 2024 Journal of pharmacopuncture Vol.27 No.1

Phlebotomy, a therapeutic method of bloodletting typically performed using a needle, has a traditional technique known as “Fasd.” In this method, blood is extracted by creating a longitudinal incision on a vein (3-5 mm) with a surgical scalpel blade, usually blade No. 11. Due to the incision in the vessel wall, establishing hemostasis is more challenging compared to conventional methods. Hemostasis is usually achieved within minutes after Fasd. We present a case highlighting an uncommon yet significant complication of traditional phlebotomy. A 55-year-old man with no prior medical conditions underwent traditional phlebotomy at an academic traditional medicine clinic. Senior MD-PhD students in Iranian Traditional Medicine, under professor supervision, performed Fasd. A sterile scalpel blade No. 11 was used to create a longitudinal incision of approximately 4 mm on the patient’s median basilic vein in the right hand. After removing 400 cc of blood, a pressure dressing was applied to the incision site. Despite attempts such as hand elevation, ice pack application, prolonged direct pressure, and tight elastic bandaging, bleeding from the incision persisted. After an hour of supportive therapy, hemostasis was eventually achieved within a few minutes using burnt cotton dressing (a traditional method for blood hemostasis). Following intravenous hydration, the patient was discharged in stable condition and reported no issues during the one-month follow-up. The traditional phlebotomy (Fasd) carries the risk of serious complications, including uncontrolled and prolonged bleeding. Further research on the efficacy and safety of burnt cotton dressing for controlling hemostasis is recommended.

Efficacy of plasmapheresis in neutropenic patients suffering from cytokine storm because of severe COVID-19 infection

Alireza Sadeghi,Somayeh Sadeghi,Mohammad Saleh Peikar,Maryam Yazdi,Mehran Sharifi,Safie Ghafel,Farzin Khorvash,Behrooz Ataei,Mohammad Reza Safavi,Elahe Nasri 대한혈액학회 2023 Blood Research Vol.58 No.2

Background With the emergence of the coronavirus disease 2019 (COVID-19) and inability of healthcare systems to control the disease, various therapeutic theories with controversial responses have been proposed. Plasmapheresis was administered as a medication. However, the knowledge of its efficacy and indications is inadequate. This study evaluated the use of plasmapheresis in critically ill patients with cancer. Methods This randomized clinical trial was conducted on 86 patients with malignancies, including a control group (N=41) and an intervention group (N=45) with severe COVID-19 during 2020-21. Both groups were treated with routine medications for COVID-19 management according to national guidelines, and plasmapheresis was applied to the intervention group. C-reactive protein (CRP), D-dimer, ferritin, lactate dehydrogenase, hemoglobin, and white blood cell, polymorphonuclear, lymphocyte, and platelet levels were measured at admission and at the end of plasmapheresis. Other variables included neutrophil recovery, intensive care unit admission, intubation requirements, length of hospital stay, and hospitalization outcomes. Results CRP (P <0.001), D-dimer (P <0.001), ferritin (P =0.039), and hemoglobin (P =0.006) levels were significantly different between the groups after the intervention. Neutrophil recovery was remarkably higher in the case than in the control group (P <0.001). However, plasmapheresis did not affect the length of hospital stay (P=0.076), which could have significantly increased survival rates (P <0.001). Conclusion Based on the study findings, plasmapheresis led to a significant improvement in laboratory markers and survival rate in patients with severe COVID-19. These findings reinforce the value of plasmapheresis in cancer patients as a critical population suffering from neutropenia and insufficient immune responses.

Oyster Shell Disposal: Potential as a Novel Ecofriendly Antimicrobial Agent for Packaging: a Mini Review

Sadeghi, Kambiz,Park, Kitae,Seo, Jongchul Korea Society of Packaging Science and Technology 2019 한국포장학회지 Vol.25 No.2

The management of oyster shell disposal is an ongoing challenge in the southern coast of Korea because of continuously dumping the oyster shell in environment. Oyster shell wastes could be a biocidal alternative after calcination using a heat treatment. Calcined oyster shell is normally obtained through thermally conversion of $CaCO_3$ (main component in oyster shell (96%)) into CaO. This study provides a brief overview of oyster shell disposal and its potential as an antimicrobial agent with a focus on calcination process, antimicrobial mechanisms, and packaging applications.

AoI Analysis and Optimization in Systems with Computations-Intensive Updates

Sadeghi Vilni, Saeid,Moltafet, Mohammad,Leinonen, Markus,Codreanu, Marian 한국통신학회 2023 Journal of communications and networks Vol.25 No.5

We consider a status update system consisting of a sampler, a controller, a processing unit, a transmitter, and a sink. The sampler generates a sample upon receiving a request from the controller and the sample requires further processing before transmission, hence is computation-intensive. This is mathematically modeled by a server called process server. After processing the sample, the status update packet is generated and sent to the transmitter for delivery to the sink. This is mathematically modeled by a server called transmit server. The service time of each packet at the transmit and process servers follow geometric distributions. Moreover, we consider that the servers serve packets under the blocking policy, i.e., whenever a server is busy at the arrival time of a new packet, the new arriving packet is blocked and discarded. We analyze the average age of information (AoI) for two fixed policies, namely, 1) zero-wait-one policy and 2) zero-wait-blocking policy. According to the former policy, the controller requests sampling when there is no packet in the system. According to the zero-wait-blocking policy, the controller requests a sample whenever the process server is idle. Furthermore, we develop an optimal control policy to minimize the average AoI using the tools of Markov decision process (MDP). In numerical results, we evaluate the performance of the policies under different system parameters. Moreover, we analyze the structure of the optimal policy.

Resisting biopower for reproductive rights: Iranian women’s hashtags

Sadeghi Zahra 이화여자대학교 아시아여성학센터 2022 Asian Journal of Women's Studies(AJWS) Vol.28 No.4

According to Foucault, governments use biopower to take advantage of numerous and diverse techniques for the subjugation of bodies and controlling populations. Although he never discussed gender directly, women’s bodies and natural life processes have always been sites of power and control. This paper seeks to show how Iran’s recent Youthful Population and Protection of the Family Law is an example of the exercise of biopower that controls women’s reproduction and denies them access to contraceptives. This is based on how women have reacted and resisted it using the social media platforms of Twitter with # حقوق_باروری (#reproductive_rights).

Nurse Attitude-Related Barriers to Effective Control of Cancer Pain among Iranian Nurses

Sadeghy, Adel,Mohamadian, Robab,Rahmani, Azad,Fizollah-zadeh, Hussein,Jabarzadeh, Franak,Azadi, Arman,Rostami, Hussein Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4

Background: Many cancer patients still experience pain worldwide. There are many barriers for effective control of cancer pain and many of these are related to health care providers. There is a need for further investigation of these barriers. The aim of this study was to investigate nurse-related barriers to control of cancer pain among Iranian nurses. Materials and Methods: In this descriptive study 49 nurses from two hospitals affiliated to Tabriz and Ardebil Universities of Medical Sciences participated using a census sampling method. A demographic and profession related checklist and Barriers Questionnaire II (BQ-II) were used for data collection. Results: The results showed negative attitudes of participants regarding control of cancer pain. Participants believed that cancer pain medications do not manage cancer pain at acceptable levels; patients may become addicted by using these drugs; cancer pain medications have many uncontrollable effects; and controlling cancer pain may distract the physicians from treating disease. Conclusions: Iranian nurses have negative attitudes toward pain control in cancer patients especially about effectiveness of pain medication and their side effects. Educational intervention to reduce these misconceptions is needed.

Production of Recombinant Human Interleukin-11 (IL-11) in Transgenic Tobacco (Nicotiana tabacum) Plants

Sadeghi, Abdorrahim,Mahdieh, Majid,Salimi, Somayeh The Korean Society of Plant Biotechnology 2016 식물생명공학회지 Vol.43 No.4

Interleukin-11 (IL-11) is a cytokine that plays a key regulatory role in the immune system. Recombinant human IL-11 (rhIL-11) exerts a preventative effect against apoptotic cell death and inhibits preadipocyte differentiation. IL-11 also is used to stimulate the bone marrow to produce platelets in order to prevent low platelets that may be caused by chemotherapy. Unfortunately, the high production cost of IL-11 associated. In this study, we investigated the feasibility of transgenic plants for the cost-effective production of rhIL-11. Production of rhIL-11 proteins in whole-plant expression system will be more economical when compared to the current E. coli based expression system. The human rhIL-11 gene was codon optimized to maximize plant host system expression. IL-11 expression vector under the control of a constitutive cauliflower mosaic virus 35S (CaMV 35S) promoter was introduced into tobacco by Agrobacterium-mediated transformation. The 5'-leader sequence (called ${\Omega}$) of tobacco mosaic virus (TMV) as a translational enhancer was added to construct. Transgenic tobacco plants expressing various levels of rhIL-11 protein were generated. Western blotting of the stably transformed lines demonstrated accumulation of the appropriately sized rhIL-11 protein in leaves. This research demonstrated the efficacy of using tobacco as an expression system for the production of rhIL-11.

Interaction between different nitrogen fertilizer levels and maize-bean intercropping patterns

Sadeghi, Hossein,Kazemeini, Seyed Abdolreza The Ecological Society of Korea 2012 Journal of Ecology and Environment Vol.35 No.4

In order to investigate the effects of different maize-bean intercropping patterns, and of nitrogen fertilizers on morphological and yield related traits, a factorial study based on Randomized Complete Block Design (RCBD) was performed during the 2010 and 2011 growing seasons in a research filed of Shiraz University, Iran. The first factor of the study was seven different ratios of Maize-Bean intercropping system (Maize sole cropping, Bean sole cropping, and intercropping of maize/bean at the ratios of 1/3, 1/1, 2/3, 3/2 and 3/1) and the second factor was three nitrogen (N) fertilizer application levels (0, 100 and 200 kg N/ha). Results showed that with respect to increasing the levels of N fertilizer, the yield of bean sole cropping decreased but the yield of maize sole cropping increased. On the other hand, in intercropping systems with N fertilizer application, the yield of both crops increased. Results of total land equivalent ratio (LER) for both crops showed that the highest LER value under both 100 and 200 kg N/ha application was that of M1B1 (1 seed of maize after 1 seed of bean, consecutively, on a row with same distance). Under no N fertilizer application the highest LER value was that of M2B3 (2 seeds of maize after 3 seeds of bean, consecutively, on a row with same distance). Overall, it can be concluded that M1B1 is the best intercropping pattern in maize-bean intercropping systems and that the application of N fertilizer can be effective within practical settings of intercropping agriculture, resulting in higher yields.

Change in three dry rangeland species growth and soil properties by compost application

Sadeghi, Hossein,Shourije, Fatemeh Ansar,Masoudi, Masoud The Ecological Society of Korea 2012 Journal of Ecology and Environment Vol.35 No.2

There are different types of compost used as soil conditioners and fertilizers. Plants can have different responses to different forms of compost. This field study was performed to examine the effects of different types of compost on growth factors of three dry rangeland species (Atriplex, $Atriplex$ $lentiformis$; Saltwort, $Seidlitzia$ $rosmarinus$; Haloxylon, $Haloxylon$ $persicum$) and soil properties. The experiment was conducted in the Fars Province of Iran during the year 2010-2011. Compost applications consisted of compost tea, solid compost (SC), solid and liquid mixture (MX) and no compost as the control. The study was a factorial experiment based on a randomized complete block design with 3 replications. The results showed that all the tested compost applications enhanced the growth traits of all three species. It was also demonstrated that the use of compost significantly increased the organic matter (1% probability level [PL]), nitrogen concentration (5% PL), phosphorous (5% PL) and potassium (5% PL) concentrations of the soil. The soil's pH level was unchanged (range, 7.3 to 7.6), and the sodium concentration was also significantly decreased (1% PL) by the use of compost. The higher responses were observed in canopy volume and soil sodium and the lower were observed in stem diameter and soil pH level. Among the three plants in the study, Atriplex showed the best response to the application of compost. Based on the results of this study, it can be recommended that the best compost application to increase growth and improve soil condition is the mixed compost (MX) for Atriplex and the SC for Saltwort and Haloxylon.