동기의 (冬基) 광릉천의 육수학적 (陸水學的) 연구

임기흥(Ki Hung Rim),홍사오(Sa Uk Hong) 한국식물학회 1964 Journal of Plant Biology Vol.7 No.1

RIM, Ki Hunng^* and HONG, Sa Uk^(**)(^*Coll. of Pharmacy, Seoul Nat. Univ and ^**Coll. of Pharmacy, Sungkyunkwan Uuiv.) Limnological study of Kwangneung river in winter season. Kor. Jour. Bot. Ⅶ (1):15-19, 1964. In this stndy, we examined the quality of water and the kinds of algae and insects the Oksukchon river along the length between Kwannung and the Han river during winter. Also examined is the relation between the quality of water and the flesh water plants in sevral significant points along the Oksukchon river between Kwannung and the Han river. We dicovered that the gradual pollution of the quality of water in places near vilages and towns reasulted in a considerable change of life in water. The present qualiy of water skows a remarkable difference from the limnological report of the winter of the year 1960^((8)) which we previously reported, and a cosiderable change in kinds of fish and water plant since then were noticed.

感潮河川水의 陸水學的 硏究 : 漢江下流 金浦大橋附近水域의 水質變動에 관하여 Variation of Water Qualities Near the Kimpo Bridge in the Down Area of Han River

洪思澳,羅圭煥,慶春浩 成均館大學校 1980 論文集 Vol.28 No.-

The variation of water qualities in Kimpo of Han river was surved according to the tidal change and also investigated seasonal and regional variation of water qualities in june on summer season and in cotober on autumn season during 1979. Between the surface and the bottom in this Kimpo of Han river the water qualities didn't found any significant difference and also didn't found any difference in periodically. Considering from the value of Cl^-, SO^-_4^2, Na and total hardness the water qualities in Kimpo of Han river may be influenced by a little of the tidal water. The content of nitrogen, Cl^-, phosphate as a pollutant was foung in autumn on dry seaon higher more than in summer on rainy season. Judging from the seasonal variation of water qualities it was more polluted in autumn on dry season than in summer on rainy season. Especially in the drying season on autumn it was considered to be influenced from the sewverly polluted waste water of Bulgwang river and Anyang river. Compared with the water qualities in each site which have deviced 3 sampling points site 1, 2 and 3. Site 1 is north side of this area in which the waste water of Bulgwang river flow down mainly, site 2 is middle of this ares and site 3 is south side in which the waste water of Anyang river flow down mainly. In generally, the water quslities of all those sampling sites were remarkably polluted and especially in site 3 under the influence of Anyang river was found severly pollution than in site 2. The plankton of saprobic species such as Oscillatoria sp., Vorticella sp., Spirogyra sp. and Mougeotia scalaria, which was indicated for the pollution were found much in this area. So it could recognized that the water quality of Kimpoin Han river were remarkably polluted. Also it found some brackish species of planktons such as Brachionus sp., Sinocalanus tenellus and Alona guttata in this area so it considered to be influenced more or less by tidal water.

피씨비(PCB) 中毒에 미치는 프라센타(Placenta)의 效果

洪思澳,李香雨,鄭相允 成均館大學校 1983 論文集 Vol.33 No.-

This study was undertaken to investigate the effects of placenta on the toxicity of KC-400 in rabbits. Rabbits were treated with 800㎎ of KC-400 in 2㎖ olive oil via IP injection intermittently day after day for a week and were successively administered with 2㎖ of the placenta extracts via I. V. injection twice a day after day as well as with the placenta extracts with 50 ㎎ of vitamin C as well. The results obtained in this experiment were as follows: 1. When the experimental animals were treated with human placenta, there wasn't any alteration of the hematochemical indicators such as RBC, WBC, Hgb, Het, serum Cholesterol, s-GOT, s-GPT, serum Alkaline Phosphatase and Total lipids in serum. 2. According to the experiment of PCB poisoning, while s-C, s-GPT, s-ALP, and s-TL were increased, RBC, WBC, Hgb and Het were decreased during the experimental periods respectively. 3. The placenta extracts normalized the hematochemical indicators of the PCB poisoned animals after one day treated by the placenta extracts. 4. The combined treatment with the placenta extracts and vitamin C was the same effect as the single placenta treatment only; they were not significant in the t-test. 5. The placenta extracts inhibited the serum tyrosinase activity of the rabbits which was induced by PCB in vivo and in vitro respectively. By the combined treatment with the placenta extracts and vitamin C, the activity of tyrosinase was remarkably inhibited in comparison with the single treatment with the placenta alone.

東海岸汽水湖의 陸水學的 硏究

洪思澳,羅圭煥 成均館大學校 1975 論文集 Vol.20 No.-

1. The quality of water and distribution of plankton were investigated of the 6 brackich lakes. Namely Hyang lake, Kwang po lake., Mai lake, Young rang lake, Song ji lake and Hwajin po lake, those which were situated in the east shore during May to December in 1972 and was studied limnological features of those 6 brackish lakes. 2. The average value of Cl'content, hardness and conductivity which had closely influence on the brackish water was measured in those 6 lakes. In the Hwa jin po lake, it found most high value of Cl'content, hardness and conductivity than the other 5 lakes and in the Kwang po lake, it found most lower value of those than the others. 3. From view point of monthly variation of the quality of water, the average value of Cl^-content, hardness and conductivity were a little higher during May and December than during August and October. Compared with the quality of water during May and during Deumber, during May it was substantially higher than during December. In all of the examined lakes except Song ji and Young rang it was substantially higher during August than during September but in Kwang po and Mai lakes, the average value of Cl￣content, hardness during September were higher than during August. 4. 29 sepecies of zooplankton and 82 species of phytoplankton were found in those 6 brackish lakes and so the total 111 species of plankton were confirmed. The dominant phytoplankton species were Lyngbya majuscula, Cocconeis placentula and Spyrogyra sp. and dominant zooplankton species were Sinbcalamus tenellus, Nauplius of Copepoda and Brachionus calyciflorus in those brackish lakes.

韓國産 복어毒의 毒性學的 硏究

洪思澳,劉永瓚 成均館大學校 科學技術硏究所 1983 論文集 Vol.34 No.2

Tetrodon poisoning also known as fugu poisoning, occurs chiefly in countries surrounding the South China Sea. It has been known for long time that tetrodotoxin which is the purified toxic principle is responsible for the poisoning. Crystalline tetrodotoxin is the most potent of the substances that can interfere with the production of action potentials in excitable cells and also unique in action only on changes in sodium permeability. It was reported that the occurence of tetrodotoxin as well as its distribution in the tissues is varied from species to species. Furthermore, the seasonal variation of toxicity was observed in ovaries of female tetrodon fish. Fugu ocellatus obscurum which is one species of tetrodon families inhabit only around Yellow Sea of Korea and Yantzu-Chiang of China. In this study, tetrodotoxin was extracted and purified from Fugu ocellatus obscurum and the toxicity of the tetrodotoxin was compared with the toxin from other species. In addition, the toxicological and pharmacological tests were performed and the results were as followings. 1. Among the various tissues of Fugu ocellatus obscurum, ovaries, liver and bile juice exhibited the potent toxicity while skin and testis of tetrodon fish showed relatively low toxicity. 2. LD_50 of the crude tetrodotoxin was about 11.8 ㎍/kg and that of the purified toxin. was 11.2㎍/kg 3. Infrared spectrum of the purified tetrodotoxin was almost exactly same pattern as the spectrum of standard tetrodotoxin. 4. The gas chromatographic isolation of TMS, derivatized substance of C_9-base was useful on a OV-101, especially, owing to the selective sensitivity for detection of TSD, the assay of tetrodotoxin in microquantity has been analyzed successfully. Also, tetrodotoxin could identified by means of GC/MS obtained from molecular ion at m/e 407 and fragment at m/e 392 (M-15) due to the C_9-base TMS. 5. The twitch tension of gastrocmemius muscle induced by tibial nerve stimulation was reduced gradually by the cumulative tetrodotoxin (5㎍/kg every 10 minutes) upto 30 minutes, and then the tension was completely abolished. The blood pressure and heart rate, however, showed maximal depression at the final concentration of 10㎍/kg of the tetrodotoxin, and no further depression thereafter. 6. In the isolated rabbit atria, the tetodotoxin produced minimal depression. In the isolated rabbit duodenum, a large doses of tetrodotoxin caused dose-related increase of motility. But pretreatment with tetrodotoxin did not affect the acetylcholine of norepinephrine response in the isolated duodenum.

Di-(2-ethyl hexyl) phthalate(DEHP)가 rat의 혈액상 및 약물대사효에 미치는 영향

임수한,홍사욱 成均館大學校 科學技術硏究所 1990 論文集 Vol.41 No.1

Di-(2-ethylhexyl) phthalate(DEHP), one of plasticizers in plastic has recently been reported as a potential hepatotoxic agent. Liver enlargement associated with a decrease in the activity of mitochondrial enzyme and modification in biological response of xenobiotics after oral or intraperitoneal administration of DEHP has been observed in rodents. However, their subtle toxic effects have not been fully investiqated and thus more detailed studies are required. In this paper, we examined the toxic effect of DEHP on the liver and kidney function and biochemical parameters in rats. The biochemical parameters such as AST, ALT, ALP, LDH, BUN, albumin and total protein in serum were gradually increased by DEHP treatment. And more increasing tendency was observed by concomitant ethanol treatment. The contents of cytochrome P-450 and activity of NADPH-cytochrome c reductase in hepatic microsomal fraction were increased in initial period and then decreased, but those in renal microsomal fraction were little increased. However, toxic responses of DEHP in hepatic and renal cytochrome P-450 content and the activity of NADPH-cytochrome c reductase were a little suppressed by the administration of ethanol. The activity of Glucose-6-phosphatase in hepatic homogenate was decreased and MDA value in the serum and microsomal fraction of liver and kidney was significantly increased by the administration of DEHP but those of above biochemical function were keeping slowly by ethanol concomitant treatment.

Polychlorinated Biphenyl 毒性에 미치는 人蔘 및 Riboflavin tetrabutylate의 影響

尹泰圭,洪思澳,趙台淳 成均館大學校 科學技術硏究所 1983 論文集 Vol.34 No.1

The effects of ginseng extract, riboflavin tetrabutylate(B_2-but.) and vitamin E on toxicity of polychlorinated biphenyls(PCB) were examined in rabbits. Serum total lipid and TBA value were markedly increased by PCB administration in the experimental animals. However, the administration of Ginseng extract or B_2-but. significantly inhibited the elevation of serum total lipid as well as TBA value. The activity of δ-aminolevulinic acid dehydrase in red blood cells was also significantly stimulated by PCB and this stimulation was inhibited by the administration of Ginseng extract. Furthermore, the elevations of the activities of serum GOT and GPT by PCB were also prevented by the administration of Ginseng extract and B_2-but.

Urea Docomposition and its turnover Time in Euphotic Layer of Reservoires in the North Han Hiver System

삼전촌서좌무,조규송,홍사욱,이해금 江原大學校 附設 環境硏究所 1989 環境硏究 Vol.6 No.-

The in situ rate of urea decomposition was measured in the euphotic layer of three reservoirs located in the North Han River System. The urea decomposition rates (as sum of incorporation rate of urea carbon into particulate matter and CO_(2) liberation rate into water from urea) in surface waters were 12, 80 and 54 μmol urea · m^(-3) day^(-I), in Lake Soyang, Lake Chuncheon and Lake Euiam. The greater part of urea decomposition took place with the C0_(2) liberation into water. High rates of urea carbo incorporation were obtained at surface layer, while low rates were found in lower layer and the dark bottles. The decomposition rate of urea, the carbon incorporation rate, and the CO_(2) liberation rate decreased with depth. The vertical distributions of the urea decomposition rate showed similar patterns to those of photosynthesis. The turnover rates of urea in the three reservoirs were calculated respectively as 41,6.1 and 3.4 days at the surface, and the values increased with depth. 북한강수계 3개 인공호수의 생산층에 있어서 현장법으로 요소 분해속도를 측정했다. 요소분해속도(요소에서 유래도는 탄소가 수중생물로 흡수되는 량과 이산화탄소로서 수중에 방출되는 량의 합)는 소양호, 춘천호 및 의암호의 표층수에서 각각 12, 80, 54μmol Urea m^(-3)·day^(-1)였다. 요소 분해는 대부분이 이산화탄소 형태로 수중에 방출된다. 요소태탄소의 흡수속도는 표층에서 높은 값이 관찰됐으나 생산층의 하층 및 암조건에서는 낮았다. 요소분해속도, 요소태탄소의 흡수속도 및 이산화탄소의 방출 속도는 깊이에 따라 감소됐다. 요소분해속도와 광합성의 수직분포는 유사하였다. 각 호수의 표층수에 있어서 회전시간은 소양호, 춘천호 및 아ㅢ암호에서 4.1, 6.1 및 3.41일로 계산되며 이 값은 깊이에 따라 증가됐다.

牙山人工湖의 理化學的水質調査

沈英燮,羅圭煥,洪思澳 成均館大學校 1978 論文集 Vol.25 No.-

The surface and bottom of the water quality in the Asan artificial reservoir have investigated in 6 sites according to the geographycal view points during 3 seasons, summer, autumn and winter. As compared the water quality of two areas near the dike with upper area at 4km distance from dike, it was not found any difference. Vertical variation of water quality was not found certainly difference between the surface and the bottom. Because the depth of this reservoir was no more than 3m, the water temperature was 1℃ high in the surface than bottom in summer, the conductivity increase 7.5μ? high in surface but in autumn and winter the conductivity increase in the bottom especially 12μ? and 13.2μ?. The another items of water quality didn't found any difference. According to the seasonal variation of water quality, the water temperature was 25.6℃ in summer, 17.4℃ in autumn and 4℃ in winter. The concentration of Cl^- was 26.6ppm in summer and gradually increase in autumn and winter especially 103.6ppm and 267.9ppm. The total hardness exhibit much the same tendency with Cl^- and most high in winter as 134.9 ppm. The content of K and Na was lower in summer but most high in winter especially 10.0 ppm and 159.3 ppm. The water quality of the Jin wi river which is one of the water source in this reservoir was severely polluted with industrial waste water. The content of total hardness 152ppm, conductivity 565μ?, the content of COD 6.7ppm, the content of Na 550ppm and the content of Fe 1.4ppm.

춘기 한강지류 ( 안양천 , 곡릉천 ) 의 육수학적 (陸水學的) 연구

홍사오 (Sa Uk Hong) 한국식물학회 1968 Journal of Plant Biology Vol.11 No.4

The present paper discusses the relation between water pollution and aquatic organisms resulted from the study of the water quality and the kinds of algea and aquatic insects both of the An-yang River from Mt. Kwan-ak to the Han River and of the Kock-neung River from Mt. Puk-han to the Han River during the spring of 1965 and 1966. According to the change of water quality, the An-yang River might be divided into three areas. In the first area, from Mt. Kwan-ak to near An-yang town, water quality is not so polluted that many aquatic organisms such as Anisogamarus ryotoensis, Epeorus, Cambaroides, Zygnema, Batrachospermum moniliform, Draparnaldia glomerata are found. In the second area where water is polluted by the inflow of sewerage water from An-yang town, the concentration of chloride, COD, ammonia-N, nitrate-N, alkali degree increased, Therefore, few aquatic insects and algea are found. In the third area, It is much polluted by the industrial sewerage water from Yeong-dong-po; and so the aquatic organisms that indicate strong pollution such as Oscillatoria, Euglena, Tubifex are found in this area. It is also significant that the Nereis japonica that indicates the pollution of brackish water is discovered in the some area. In the case of the Kock-neung River, however, it is not clearly divided into areas, as in the case of the An-yang River, according to the pollution of water; but because of villages and towns along the river the gradual pollution of water is observed and accordingly, a considerable change in aquatic organisms is also found in this river. In the area near Il-young town, for instance, the concentration of the chloride, hardness, nitrite, nitrate is very low, and ammonia-N is not detected; and accordingly the aquatic insects that generally inhabit in mountain stream, such as Anisogamarus ryotoensis, Cambaroides, Epeorus, Thraubs, Hydropsyche are found here. In the down stream of the river, from Kock-neung to Keum-chon, the quality of water is considerably polluted and fine sands are found laid on the bottom of the stream; therefore, the aquatic insects are very few, but the algea such as Navicula, Pleusigma, Oscillatoria that indicate water pollution are found in this area.