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정화영,정강호,손수호,김경례,허정욱,송홍석 대한내과학회 1993 대한내과학회지 Vol.44 No.6
저자들은 식도내에 편평상피암과 선암이 동시에 존재하는 원발성 중복암을 경험하고, 항암화학요법을 실시하여 부분적 관해를 얻은 매우 드문 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. A 65 year old man with simultaneously occurring squamous cell carcinoma of mid-esophagus and adenocarcinoma of distal esophagus is reported. There was no continuity between the two masses. Bone scan revealed hot spots in right 3rd, 4th, 5th, and 6th ribs. Both esophageal lesions were responded to treatment with 5-fluorouracil and cisplatin. Fourteen months after the start of treatment, spinal metastasis was developed, but histologically not confirmed. Follow-up esophagoscopic findings at that time revealed 2㎝ sized ulcerative lesion in the distal esophagus only. In this report, we discussed the pathogenesis and treatment of double primary cancers.