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- 저자 : S.J. Kang (검색결과 10,627 건)
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Kang, H-S,Kim, Y-H,Lee, C-S,Lee, J-J,Choi, I.,Pyun, K-H 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-
DEREGULATION of interleukin-6 (IL-6) expression caused the synthesis and release of many inflammatory mediators. It is involved in chronic inflammation, autoimmune diseases, and malignancy. Stephania tetrandra S. Moore is a Chinese medicinal herb which has been used traditionally as a remedy for neuralgia and arthritis in China. To investigate the anti-inflammatory effects of S. tetrandra S. Moore in vitro and in vivo, its effects on the production of Il-6 and inflammatory mediators were analysed. When human monocytes/macrophages stimulated with silica were treated with 0.1-10 ㎍/㎖ S. tetranda S. Moore, the production of IL-6 was inhibited up to 50%. At these concentrations, it had no cytotoxicity effect on these cells. It also suppressed the production of Il-6 by alveolar macrophages stimulated with silica. In addition, it inhibited the release of superoxide anion and hydrogen peroxide from human monocytes/macrophages. To assess the anti-fibrosis efects of S. tetrandra S. Moore, its effects on in vivo experimental inflammatory models were evaluated. In the experimental silicosis model, IL-6 activities in the sera and in the culture supernatants of pulmonary fibroblasts were also inhibited by it. In vitro and in vivo treatment of S. tetrandra S. Moore reduced collagen production by rat lung fibroblasts and lung tissue. Also, S. tetrandra S. Moore reduced the levels of serum GOT and GPT in the rat cirrhosis model induced by CCl_4, and it was effective in reducing hepatic fibrosis and nodular formation. Taken together, these data indicate that it has a potent antiinflammatory and anti-fibrosis effect by reducing IL-6 production.
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Shin, S.W.,Suryawanshi, M.P.,Hong, H.K.,Yun, G.,Lim, D.,Heo, J.,Kang, S.H.,Kim, J.H. Pergamon Press 2016 ELECTROCHIMICA ACTA Vol.219 No.-
An array of one dimensional (1D) TiO<SUB>2</SUB> nanorods (TONRs) has been regarded as an attractive candidate for electrochemical energy conversion and as storage device due to its large surface area, effiective light scattering, and undisturbed charge transport pathway. However, the high defect/trap densities on surface of the nanostructured morphology and architecture may generally hinder the performance enhancement by providing electron-hole recombination sites. Hence, the surface passivation of nanoarchitectures based photoelectrodes has recently received much attention as an effective strategy to enhance the charge-separation and charge-transfer processes in photoelectrochemical (PEC) water splitting devices. In particular, a coating layer with narrowing band gap materials can promote enhanced light harvesting in the UV-vis region as well as surface passivation, directly supplying a driving force for charge separation and charge transfer due to band alignment. In this paper, the surface of TONRs were passivated by 10 and 30nm thick Zn(O,S) layers with a relatively narrow band gap using an atomic layer deposition technique to modulate the thickness exactly. The 10nm Zn(O,S)/TONR array exhibits a significantly enhanced photocurrent density (J<SUB>sc</SUB>) of 5.94mA/cm<SUP>2</SUP> at 1.23eV vs NHE and an incident photon-to-electron conversion efficiency (IPCE) of 49% at 374nm compared with that of TONR arrays (J<SUB>sc</SUB> of 1.99mA/cm<SUP>2</SUP> at 1.23eV vs NHE and an IPCE of 20% at 380nm). However, the PEC performance is worse in the 30nm Zn(O,S)/TONR arrays, showing a J<SUB>sc</SUB> of 3.09mA/cm<SUP>2</SUP> at 1.23eV vs NHE and an IPCE of 29% at 374nm. To clearly demonstrate these PEC behaviors, the TONR and Zn(O,S)/TONR arrays were characterized by electrochemical impedance spectroscopy (EIS), open circuit voltage decay (OCV) measurement, and X-ray photoelectron spectroscopy (XPS). The above mentioned characterizations indicate that the enhanced PEC performance of the 10nm Zn(O,S)/TONR array resulted from the (i) increased light harvesting in the UV-vis region, (ii) lower charge transfer resistance and (iii) high value of valence band offset (VBO, -1.44eV) and conduction band offset (CBO, -1.2eV) than those of the TONR. However, the deterioration of J<SUB>sc</SUB> in the 30nm Zn(O,S)/TONR array is attributed to the negative value of VBO (-0.13eV) and positive value of CBO (+0.27eV), as well as the higher charge transfer resistance to the electrolyte than that of the TONR arrays, despite of the improved light absorption in the visible region. The photocurrent densities of 10nm Zn(O,S)/TONR and 30nm Zn(O,S)/TONR photocathodes decay to 4.718mA/cm<SUP>2</SUP> (5.90mA/cm<SUP>2</SUP> at 0min) and 2.212mA/cm<SUP>2</SUP> (3.03mA/cm<SUP>2</SUP> at 0min) after 90min, respectively, they retain of about~80% and 70% of its original values. These experimental results and discussions not only provide the physical insights into the surface passivation effect and band alignment but also can open a promising route to design the thin passivation layer having the narrowing band gap energy (1.0eV~2.5eV) on the 1D TiO<SUB>2</SUB> nanostructure for further enhanced performance and realization of a TiO<SUB>2</SUB> based PEC system.
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Yu, K‐,H.,Hong, K‐,S.,Lee, B‐,C.,Oh, M‐,S.,Cho, Y‐,J.,Koo, J‐,S.,Park, J‐,M.,Bae, H‐,J.,Han, M‐,K.,Ju, Y‐,S.,Kang, D‐,W.,Appelros, P. Blackwell Publishing Ltd 2011 Acta neurologica Scandinavica Vol.123 No.5
<P>Yu K‐H, Hong K‐S, Lee B‐C, Oh M‐S, Cho Y‐J, Koo J‐S, Park J‐M, Bae H‐J, Han M‐K, Ju Y‐S, Kang D‐W, Appelros P, Norrving B, Terent A. Comparison of 90‐day case‐fatality after ischemic stroke between two different stroke outcome registries using propensity score matching analysis. Acta Neurol Scand: 2011: 123: 325–331. © 2010 John Wiley & Sons A/S.</P><P><B>Background – </B> It has not been clarified whether the disparity in ischemic stroke outcome between populations is caused by ethnic and geographic differences or by variations in case mix. Propensity score matching (PSM) analysis can overcome some analytical problems but is rarely used in stroke outcome research. This study was to compare the ischemic stroke case‐fatality between two PSM cohorts of Sweden and Korea.</P><P><B>Methods – </B> Prognostic variables related to baseline characteristics and stroke care were included in our PSM model. Then, we selected 7675 Swedish and 1220 Korean patients with ischemic stroke from each stroke registers and performed one‐to‐one matching based on propensity scores of each patient.</P><P><B>Results – </B> After PSM, all measured variables were well balanced in 1163 matched subjects, and the 90‐day case‐fatality was identical 6.2% (HR 0.997, 95%CI 0.905–1.099) in Sweden and Korea.</P><P><B>Conclusions – </B> No difference is found in the 90‐day case‐fatality in propensity score‐matched Swedish and Korean patients with ischemic stroke.</P>
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Piao, D.C.,Lee, Y.S.,Bok, J.D.,Cho, C.S.,Hong, Z.S.,Kang, S.K.,Choi, Y.J. Academic Press 2016 Protein expression and purification Vol.126 No.-
The emergence of highly pathogenic variant porcine epidemic diarrhea virus (PEDV) strains, from 2013 to 2014, in North American and Asian countries have greatly threatened global swine industry. Therefore, development of effective vaccines against PEDV variant strains is urgently needed. Recently, it has been reported that the N-terminal domain (NTD) of S1 domain of PEDV spike protein is responsible for binding to the 5-N-acetylneuraminic acid (Neu5Ac), a possible sugar co-receptor. Therefore, the NTD of S1 domain could be an attractive target for the development of subunit vaccines. In this study, the NTD spanning amino acid residues 25-229 (S25-229) of S1 domain of PEDV variant strain was expressed in Escherichia coli BL21 (DE3) in the form of inclusion bodies (IBs). S25-229 IBs were solubilized in 20 mM sodium acetate (pH 4.5) buffer containing 8 M urea and 1 mM dithiothreitol with 95% yield. Solubilized S25-229 IBs were refolded by 10-fold flash dilution and purified by one-step cation exchange chromatography with >95% purity and 20% yield. The CD spectrum of S25-229 showed the characteristic pattern of alpha helical structure. In an indirect ELISA, purified S25-229 showed strong reactivity with mouse anti-PEDV sera. In addition, immunization of mice with 20 μg of purified S25-229 elicited highly potent serum IgG titers. Finally, mouse antisera against S25-229 showed immune reactivity with native PEDV S protein in an immunofluorescence assay. These results suggest that purified S25-229 may have potential to be used as a subunit vaccine against PEDV variant strains.
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Kang, S.M.,Khan, A.L.,Waqas, M.,You, Y.H.,Hamayun, M.,Joo, G.J.,Shahzad, R.,Choi, K.S.,Lee, I.J. Gauthier-Villars ; Elsevier Science Ltd 2015 European journal of soil biology Vol.68 No.-
We studied the effects of plant growth-promoting rhizobacteria (PGPR) on the physio-hormonal attributes of pepper (Capsicum annuum L.) plants grown under low-temperature stress. After initial screening for growth promoting effect on gibberellin (GA) mutant Waito-C rice seeds, the PGPRs were analysed for gibberellins (GA) production through advanced chromatographic and spectroscopic techniques. Among 17 bacterial isolates, a novel isolate PEJ1011 produced bioactive GA<SUB>4</SUB> (8.65 ng ml<SUP>-1</SUP>) and physiologically inactive GA<SUB>20</SUB> (6.21 ng ml<SUP>-1</SUP>) and GA<SUB>9</SUB> (1.64 ng ml<SUP>-1</SUP>). The isolate PEJ1011 was identified as Serratia nematodiphila PEJ1011 using molecular techniques. To further assess it growth promoting effects, S. nematodiphila PEJ1011 was inoculated to pepper plant, where it significantly improved the growth attributes of pepper plants, while mitigated the deleterious effects of low temperature on pepper exposed to low temperature stress of 5 <SUP>o</SUP>C. It was observed that the inoculated plants grown under normal and low temperature stress contained higher endogenous GA<SUB>4</SUB> contents. To modulate cold stress, the beneficial association of PGPR up-regulated the endogenous ABA levels in pepper plants, while reduced the endogenous jasmonic acid and salicylic acid contents. This up and down regulation of stress hormones contribute to the immediate adaptation of plants exposed to low temperature stress. Current study showed the significance of S. nematodiphila PEJ1011 association to crops grown under adverse climatic conditions, and also reports the GA producing capacity of genus Serratia for the first time.
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Kang, H.R.,Lee, D.,Eom, H.J.,Lee, S.R.,Lee, K.R.,Kang, K.S.,Kim, K.H. Elsevier 2016 Journal of Functional Foods Vol.20 No.-
In search for bioactive constituents from natural resources, the ethanol (EtOH) extract of Sphagnum palustre showed significant renoprotective effects against cisplatin-induced damage in kidney cells. Phytochemical investigation of the EtOH extract led to the identification of a new flavonoid, 6-methyl-(2R,3S)-alpinone, along with six known flavonoids, four steroids, six triperpenoids, and three fatty acids. Among them, ergosterol peroxide, (3β,22E,24S)-3-hydroxy-ergosta-5,22-dien-7-one, and betulinic acid ameliorated cisplatin-induced nephrotoxicity to 80% of the control value at 125, 125 and 50@?@?M, respectively. Moreover, the elevated percentage of apoptotic cells by cisplatin was significantly reduced after co-treatment with the EtOH extract of S.palustre and ergosterol peroxide, (3β,22E,24S)-3-hydroxy-ergosta-5,22-dien-7-one, and betulinic acid. Upregulated phosphorylation of JNK and p38 by cisplatin treatment was markedly decreased after co-treatment with ergosterol peroxide, (3β,22E,24S)-3-hydroxy-ergosta-5,22-dien-7-one, and betulinic acid. These results show that blocking the MAPKs signalling cascade plays a critical role in mediating the renoprotective effect of S.palustre.
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Kang, E. S.,Hwang, J. S.,Ham, S. A.,Park, M. H.,Kim, G. H.,Paek, K. S.,Yoo, T.,Lee, W. J.,Kang, K. R.,Lee, J. H.,Choi, Y. J.,Seo, H. G. Informa Healthcare 2014 Free radical research Vol.48 No.2
<P>The omega-6 fatty acid derivative 15-Deoxy-Δ<SUP>12,14</SUP>-prostaglandin J<SUB>2</SUB> (15d-PGJ<SUB>2</SUB>) is believed to play a role in cellular protection against oxidative stress in diverse cell systems. However, the cellular mechanisms by which protection is afforded by 15d-PGJ<SUB>2</SUB> are not fully elucidated in vascular smooth muscle cells (VSMCs). In this study, we report the finding that 15d-PGJ<SUB>2</SUB> elicited a time and concentration- dependent increase in aldose reductase (AR) expression. This induction was independent of the activation of peroxisome proliferator- activated receptor γ. Inhibition of phosphatidylinositol 3-kinase (PI3K) significantly suppressed the increase in expression and promoter activity of AR induced by 15d-PGJ<SUB>2</SUB>. Luciferase reporter assays demonstrated that 15d-PGJ<SUB>2</SUB> targets the multiple stress response regions comprising the antioxidant response element in the promoter of the AR gene. 15d-PGJ<SUB>2</SUB>-mediated induction of AR promoter activity was potentiated in the presence of nuclear factor-erythroid 2-related factor 2 (Nrf2), but not in cells expressing dominant negative Nrf2. Cells treated with 15d-PGJ<SUB>2</SUB> were resistant to oxidant-induced apoptotic cell death by inhibiting production of reactive oxygen species. These effects were significantly attenuated in the presence of an AR inhibitor or small interfering RNA against AR, indicating that AR plays a protective role against oxidative injury. Taken together, these findings demonstrate that activation of PI3K by 15d-PGJ<SUB>2</SUB> increases the expression of AR through Nrf2, and increased AR activity may function as an important cellular response against oxidative injury.</P>
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Heat, heat waves, and out-of-hospital cardiac arrest
Kang, S.H.,Oh, I.Y.,Heo, J.,Lee, H.,Kim, J.,Lim, W.H.,Cho, Y.,Choi, E.K.,Yi, S.M.,Sang, D.S.,Kim, H.,Youn, T.J.,Chae, I.H.,Oh, S. Elsevier/North-Holland Biomedical Press 2016 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.221 No.-
<P>Objective: Cardiac arrest is one of the common presentations of cardiovascular disorders and a leading cause of death. There are limited data on the relationship between out-of-hospital cardiac arrest (OHCA) and ambient temperatures, specifically extreme heat. This study investigated how heat and heat waves affect the occurrence of OHCA. Methods: Seven major cities in Korea with more than 1 million residents were included in this study. A heat wave was defined as a daily mean temperature above the 98th percentile of the yearly distribution for at least two consecutive days. Results: A total of 50,318 OHCAs of presumed cardiac origin were identified from the nationwide emergency medical service database between 2006 and 2013. Ambient temperature and OHCA had a J-shaped relationship with a trough at 28 degrees C. Heat waves were shown to be associated with a 14-% increase in the risk of OHCA. Adverse effects were apparent from the beginning of each heat wave period and slightly increased during its continuation. Excess OHCA events during heat waves occurred between 3 PM and 5 PM. Subgroup analysis showed that those 65 years or older were significantly more susceptible to heat waves. Conclusions: Ambient temperature and OHCA had a J-shaped relationship. The risk of OHCA was significantly increased with heat waves. Excess OHCA events primarily occurred during the afternoon when the temperature was high. We found that the elderly were more susceptible to the deleterious effects of heat waves. (C) 2016 Elsevier Ireland Ltd. All rights reserved.</P>
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