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Van Nguyen, T.,Lee, J.,Sweredoski, Michael J.,Yang, S.J.,Jeon, S.J.,Harrison, Joseph S.,Yim, J.H.,Lee, S.,Handa, H.,Kuhlman, B.,Jeong, J.S.,Reitsma, Justin M.,Park, C.S.,Hess, S.,Deshaies, Raymond J. Cell Press 2016 Molecular cell Vol.61 No.6
<P>Cereblon (CRBN), a substrate receptor for the cullin-RING ubiquitin ligase 4 (CRL4) complex, is a direct protein target for thalidomide teratogenicity and antitumor activity of immunomodulatory drugs (IMiDs). Here we report that glutamine synthetase (GS) is an endogenous substrate of CRL4(CRBN). Upon exposing cells to high glutamine concentration, GS is acetylated at lysines 11 and 14, yielding a degron that is necessary and sufficient for binding and ubiquitylation by CRL4 CRBN and degradation by the proteasome. Binding of acetylated degron peptides to CRBN depends on an intact thalidomide-binding pocket but is not competitive with IMiDs. These findings reveal a feedback loop involving CRL4 CRBN that adjusts GS protein levels in response to glutamine and uncover a new function for lysine acetylation.</P>
Zinc selective chemosensors based on the flexible dipicolylamine and quinoline
Lee, H.G.,Lee, J.H.,Jang, S.P.,Hwang, I.H.,Kim, S.J.,Kim, Y.,Kim, C.,Harrison, R.G. Elsevier Sequoia [etc.] 2013 Inorganica chimica acta Vol.394 No.-
Zinc sensor molecules containing quinoline have been synthesized, which show fluorescence in the presence of Zn<SUP>2+</SUP>. The nitrogen in quinoline is critical to fluorescence and fluorescence enhancement is promoted by deprotonating the sensor's amide. One of the sensors is highly selective for Zn<SUP>2+</SUP> over Cd<SUP>2+</SUP> and other cations such as Hg<SUP>2+</SUP>, Fe<SUP>2+</SUP>, Mn<SUP>2+</SUP> and Ca<SUP>2+</SUP>. This selectivity can be attributed to the increased absorption of the sensor in the presence of Zn<SUP>2+</SUP> and the strong binding of Zn<SUP>2+</SUP>. Structural studies, including X-ray and NMR, show the ability of dipicolylamine (DPA) to bind in facial and meridional manners to Zn<SUP>2+</SUP>. Crystal structures of different compounds show Zn<SUP>2+</SUP> coordinating to three, four, and five nitrogens from the compounds. They also indicate that the selectivity of DPA containing compounds towards Zn<SUP>2+</SUP> may originate from Zn<SUP>2+</SUP> being stable in different coordination environments.
K_4GeP_4Se_12: a case for phase-change nonlinear optical chalcogenide
Jang, J. I.,Park, S.,Harrison, C. M.,Clark, D. J.,Morris, C. D.,Chung, I.,Kanatzidis, M. G. The Optical Society 2013 Optics letters Vol.38 No.8
<P>We report on broadband nonlinear optical (NLO) responses from a phase-change chalcogenide compound K(4)GeP(4)Se(12). Its glassy phase exhibits unusual second-harmonic generation (SHG) due to the preservation of local crystallographic order. The SHG efficiency of the glassy form can be boosted by more than 2 orders of magnitude by simple heat treatment. Strong SHG and third-harmonic generation from both glassy and crystalline compounds were characterized over a wide wavelength range of 1.2-4.0 μm. Our results imply that K(4)GeP(4)Se(12) can be utilized for various NLO applications in the mid-infrared spectrum.</P>
Analysis and extension of a biochemical network model using robust control theory
Kim, J.-S.,Valeyev, N. V.,Postlethwaite, I.,Heslop-Harrison, P.,Cho, K.-H.,Bates, D. G. John Wiley Sons, Ltd. 2010 INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONT Vol.20 No.9
<P>Mathematical models of biological processes which have been observed in vivo to be highly robust to intracellular and environmental variations should themselves display appropriate levels of robustness when analysed in silico. This paper uses techniques from robust control theory to analyse and extend a mathematical model of the interacting proteins underlying adenosine 3′, 5′-cyclic monophosphate (cAMP) oscillations in aggregating Dictyostelium cells. Starting with a previously proposed ‘minimal’ model, we show how robustness analysis using the structured singular value can identify points of structural fragility in the network. By combining these results with insights from recent results from the experimental literature, we show how the original model can be augmented with some important additional modules, comprising networks involving IP<SUB>3</SUB> and Ca<SUP>2+</SUP>. By analysing the robustness of our new extended model, we are able to show that dynamic interactions between the different modules play a pivotal role in generating robust cAMP oscillations; thus, significantly improving our understanding of the design principles underlying this complex biological system. Copyright © 2009 John Wiley & Sons, Ltd.</P>
JIN HO KANG,JOYCELYN S. HARRISON,CHEOL PARK,STEVEN J. GAIK,SHARON E. LOWTHER 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2006 NANO Vol.1 No.1
Recently, a series of single wall carbon nanotube (SWNT) polyimide nanocomposites were developed since the demand of electroactive polymeric materials as sensors and actuators for use in high temperature applications has been growing. Adding SWNTs into electroactive polyimides enhanced their electrostrictive strain as well as their mechanical integrities and chemical stability. Although an increase in piezoelectricity resulting from the incorporation of SWNTs could be expected, there has been no systematic study detailing the effect of SWNTs on piezoelectricity. In this article, the effects of various types and concentrations of SWNT on the dipole orientation and piezoelectricity were investigated using a thermally stimulated current (TSC) technique and a modified Rheovibron. It was found that the barely modified SWNTs led to a more substantial increase in the remanent polarization (Pr) than the highly modified SWNTs did. As the loading level of SWNTs increased, Pr increased.However, excessive loading of SWNTs showed a reduction in Pr since the actual poling field decreased due to a large leakage of current. The trend of the piezoelectric strain coefficient, d31, was consistent with that of Pr. The increase in interfacial polarization caused by adding SWNT was believed to be primarily responsible for the increase of Pr and d31.