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Curcumin derivatives for Type 2 Diabetes management and prevention of complications
Sara Oliveira,Tamaeh Monteiro-Alfredo,Sónia Silva,Paulo Matafome 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.6
Type 2 diabetes Mellitus (T2DM) is characterizedby chronically increased blood glucose levels, whichis associated with impairment of the infl ammatory and oxidativestate and dyslipidaemia. Although it is considered aworld heath concern and one of the most studied diseases,we are still pursuing an eff ective therapy for both the pathophysiologicalmechanisms and the complications. Curcumin,a natural compound found in the rhizome of Curcuma longa ,is well known for its numerous biological activities, as demonstratedby several studies supporting that curcumin possesseshypoglycaemic, hypolipidemic, anti-infl ammatoryand antioxidant properties, among others. These eff ects havebeen explored to the attenuation of hyperglycaemia and progressionof DM complications, being appointed as a potentialtherapeutic approach. Besides its strong intrinsic activity,the polyphenol has low bioavailability, compromisingits therapeutic effi cacy. In order to overcome this limitation,several chemical strategies have been applied to curcumin,such as drug delivery systems, chemical manipulation andthe use of adjuvant therapies. Given the promising results obtained with curcumin derivative, in this review we discussnot only the therapeutic targets of curcumin, but also itsmost recently developed analogues and their effi cacy in themanagement of T2DM pathophysiology and complications.
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M.da CT. Cavalcanti Liberato,Selene Maia de Morais,Sônia Maria Costa Siqueira,Jane Eire Silva Alencar de Menezes,Denise Nogueira Ramos,Lyeghyna Karla Andrade Machado,Islay Lima Magalha˜es 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.6
Twenty-three honey samples of Apis mellifera L. forged on plants from northeastern Brazil were analyzed to determine total phenolic content, flavonoid content, antioxidant activity, and antiacetylcholinesterase activity. The total phenol content was determined by using the Folin–Ciocalteu method, and the flavonoid content was analyzed using by the aluminum chloride method. The antioxidant activity was evaluated using the diphenyl-1-picrylhydrazyl–scavenging test. Honey samples from Lippia sidoides Cham. (mean [±standard deviation] 50% inhibitory concentration [IC_50], 4.20±1.07 mg/mL) and Myracrodruon urundeuva Fr. All. (IC_50, 28.27±1.41 mg/mL) showed better antioxidant activity and presented higher total phenol values (108.50±3.52 mg gallic acid equivalents/100 g for L. sidoides and 68.55±1.01 mg gallic acid equivalents/100 g for M. urundeuva). Several honey samples had relevant results on antiacetylcholinesterase assay. The biological activity of honeys is related to their floral origin, and medicinal plants constitute a useful resource for the generation of functional foods.
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