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Curcumin derivatives for Type 2 Diabetes management and prevention of complications
Sara Oliveira,Tamaeh Monteiro-Alfredo,Sónia Silva,Paulo Matafome 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.6
Type 2 diabetes Mellitus (T2DM) is characterizedby chronically increased blood glucose levels, whichis associated with impairment of the infl ammatory and oxidativestate and dyslipidaemia. Although it is considered aworld heath concern and one of the most studied diseases,we are still pursuing an eff ective therapy for both the pathophysiologicalmechanisms and the complications. Curcumin,a natural compound found in the rhizome of Curcuma longa ,is well known for its numerous biological activities, as demonstratedby several studies supporting that curcumin possesseshypoglycaemic, hypolipidemic, anti-infl ammatoryand antioxidant properties, among others. These eff ects havebeen explored to the attenuation of hyperglycaemia and progressionof DM complications, being appointed as a potentialtherapeutic approach. Besides its strong intrinsic activity,the polyphenol has low bioavailability, compromisingits therapeutic effi cacy. In order to overcome this limitation,several chemical strategies have been applied to curcumin,such as drug delivery systems, chemical manipulation andthe use of adjuvant therapies. Given the promising results obtained with curcumin derivative, in this review we discussnot only the therapeutic targets of curcumin, but also itsmost recently developed analogues and their effi cacy in themanagement of T2DM pathophysiology and complications.
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